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Coexpression cluster:C3726: Difference between revisions

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{{Coexpression_clusters
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|full_id=C3726_CD34_CD4_Natural_CD14_CD8_CD133_CD14CD16
|id=C3726
}}

Latest revision as of 12:31, 17 September 2013


Full id: C3726_CD34_CD4_Natural_CD14_CD8_CD133_CD14CD16



Phase1 CAGE Peaks

Hg19::chr18:48556964..48556972,-p@chr18:48556964..48556972
-
Hg19::chr21:43430591..43430653,+p@chr21:43430591..43430653
+
Hg19::chr2:113033617..113033657,-p@chr2:113033617..113033657
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte5.72e-23136
hematopoietic lineage restricted progenitor cell3.22e-19120
nongranular leukocyte4.79e-19115
hematopoietic stem cell1.17e-18168
angioblastic mesenchymal cell1.17e-18168
hematopoietic cell1.61e-18177
hematopoietic oligopotent progenitor cell4.61e-16161
hematopoietic multipotent progenitor cell4.61e-16161
connective tissue cell1.77e-13361
mesenchymal cell2.15e-13354
classical monocyte6.14e-1342
CD14-positive, CD16-negative classical monocyte6.14e-1342
motile cell1.31e-12386
defensive cell5.49e-1148
phagocyte5.49e-1148
lymphoid lineage restricted progenitor cell7.27e-1152
lymphocyte2.73e-1053
common lymphoid progenitor2.73e-1053
nucleate cell5.32e-1055
stem cell6.27e-10441
myeloid leukocyte6.69e-1072
granulocyte monocyte progenitor cell1.03e-0967
multi fate stem cell3.31e-09427
macrophage dendritic cell progenitor6.46e-0961
somatic stem cell7.33e-09433
myeloid lineage restricted progenitor cell2.63e-0866
monopoietic cell4.30e-0859
monocyte4.30e-0859
monoblast4.30e-0859
promonocyte4.30e-0859
intermediate monocyte1.49e-079
CD14-positive, CD16-positive monocyte1.49e-079
myeloid cell3.20e-07108
common myeloid progenitor3.20e-07108
B cell3.24e-0714
mature alpha-beta T cell3.59e-0718
alpha-beta T cell3.59e-0718
immature T cell3.59e-0718
mature T cell3.59e-0718
immature alpha-beta T cell3.59e-0718
Uber Anatomy
Ontology termp-valuen
connective tissue5.99e-13371
hematopoietic system9.48e-1198
blood island9.48e-1198
bone marrow1.98e-0976
bone element1.50e-0882
hemolymphoid system1.62e-08108
immune system5.00e-0793
skeletal element8.70e-0790


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.16.06693
MA0004.11.93041
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.11.24048
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.11.70328
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.668628
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.11.31954
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.11.55117
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.846801
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.11.3784
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.11.12079
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.752137
MA0146.11.70974
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.23.37171
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.21.2307
MA0047.20.973066
MA0112.21.34467
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.12.76014
MA0163.10.776149
MA0164.11.01792
MA0080.20.643061
MA0018.22.26143
MA0099.20.902716
MA0079.28.812
MA0102.21.88331
MA0258.10.519674
MA0259.11.40979
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BHLHE40#8553229.91454236465160.001467483527106140.00939569103037265
E2F1#186934.907389214879320.008460985347239390.0325136819736675
FOSL2#2355211.28680040304110.0100534586973120.0376726049617367
YY1#752834.911170749853860.008441455341808260.0329207301883164



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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