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{{Coexpression_clusters
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|full_id=C1712_CD14_Peripheral_Basophils_Mast_CD14CD16_CD34_Natural
|id=C1712
}}

Latest revision as of 11:50, 17 September 2013


Full id: C1712_CD14_Peripheral_Basophils_Mast_CD14CD16_CD34_Natural



Phase1 CAGE Peaks

Hg19::chr13:99934429..99934435,+p@chr13:99934429..99934435
+
Hg19::chr15:67413848..67413862,+p@chr15:67413848..67413862
+
Hg19::chr17:72776166..72776178,-p@chr17:72776166..72776178
-
Hg19::chr19:2495374..2495386,-p@chr19:2495374..2495386
-
Hg19::chr8:48540648..48540655,+p@chr8:48540648..48540655
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
classical monocyte4.82e-6042
CD14-positive, CD16-negative classical monocyte4.82e-6042
myeloid leukocyte9.03e-5472
defensive cell6.71e-5248
phagocyte6.71e-5248
intermediate monocyte1.02e-469
CD14-positive, CD16-positive monocyte1.02e-469
myeloid lineage restricted progenitor cell1.83e-4666
granulocyte monocyte progenitor cell1.07e-4567
monopoietic cell2.20e-4459
monocyte2.20e-4459
monoblast2.20e-4459
promonocyte2.20e-4459
macrophage dendritic cell progenitor8.81e-4361
leukocyte1.84e-42136
nongranular leukocyte1.36e-36115
myeloid cell5.46e-34108
common myeloid progenitor5.46e-34108
hematopoietic stem cell3.92e-33168
angioblastic mesenchymal cell3.92e-33168
hematopoietic lineage restricted progenitor cell4.28e-32120
hematopoietic cell4.12e-31177
hematopoietic oligopotent progenitor cell2.80e-28161
hematopoietic multipotent progenitor cell2.80e-28161
stuff accumulating cell2.47e-2687
basophil4.73e-173
single nucleate cell8.05e-173
mononuclear cell8.05e-173
non-classical monocyte8.02e-163
CD14-low, CD16-positive monocyte8.02e-163
natural killer cell8.44e-163
pro-NK cell8.44e-163
mesenchymal cell4.15e-13354
connective tissue cell1.02e-12361
motile cell2.47e-11386
stem cell5.49e-10441
multi fate stem cell1.22e-09427
somatic stem cell2.09e-09433
circulating cell1.21e-086
Uber Anatomy
Ontology termp-valuen
bone marrow5.78e-4376
hematopoietic system7.91e-4198
blood island7.91e-4198
bone element1.94e-3982
hemolymphoid system1.65e-36108
skeletal element1.85e-3590
immune system3.85e-3493
skeletal system2.27e-31100
lateral plate mesoderm1.43e-16203
musculoskeletal system1.57e-16167
connective tissue3.51e-12371
mesoderm1.84e-08315
mesoderm-derived structure1.84e-08315
presumptive mesoderm1.84e-08315


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.280184
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.369468
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.569896
MA0050.10.613347
MA0051.10.731787
MA0052.12.35606
MA0055.10.0853006
MA0056.10
MA0057.10.554727
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.791444
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.0140295
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.818263
MA0089.10
MA0090.10.556637
MA0091.11.52322
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.11.00065
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.973423
MA0115.11.35895
MA0116.10.994489
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.12.01656
MA0146.10.143081
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.527987
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.20.839774
MA0065.20.880827
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.514087
MA0155.10.813062
MA0156.10.480289
MA0157.12.04894
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.21472
MA0163.11.05321
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.20.0442129
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538314.61468107538220.0006498237314125670.00532289730862723



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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