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{{Coexpression_clusters
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|full_id=C2662_Fibroblast_mesenchymal_cervical_leiomyoma_Smooth_Mesothelial_Olfactory
|id=C2662
|ontology_enrichment_celltype=CL:0000055!8.10e-24!180;CL:0000220!8.47e-19!246;CL:0002321!1.42e-18!248;CL:0000057!9.98e-16!75;CL:0000066!2.69e-10!254;CL:0000680!5.49e-09!57;CL:0000056!5.49e-09!57;CL:0000355!5.49e-09!57;CL:0000393!6.07e-09!60;CL:0000211!6.07e-09!60;CL:0000548!1.04e-08!679;CL:0000004!1.04e-08!679;CL:0000255!1.04e-08!679;CL:0000222!1.89e-08!119;CL:0002620!2.65e-08!23;CL:0000192!3.23e-08!42;CL:0000514!3.23e-08!42;CL:0000012!5.08e-08!682;CL:0000187!6.14e-08!54;CL:0000077!9.66e-07!19
|ontology_enrichment_disease=DOID:2394!6.32e-09!14;DOID:120!6.36e-09!27;DOID:193!1.47e-08!29
|ontology_enrichment_uberon=UBERON:0003102!1.72e-17!95;UBERON:0000475!1.36e-14!365;UBERON:0005256!3.10e-12!143;UBERON:0000468!6.61e-12!659;UBERON:0000914!8.58e-12!83;UBERON:0002329!8.58e-12!83;UBERON:0003077!8.58e-12!83;UBERON:0003059!8.58e-12!83;UBERON:0007282!8.58e-12!83;UBERON:0009618!8.58e-12!83;UBERON:0007285!8.58e-12!83;UBERON:0002100!1.39e-11!216;UBERON:0000481!2.00e-11!347;UBERON:0000486!7.25e-11!82;UBERON:0003104!3.82e-10!238;UBERON:0009142!3.82e-10!238;UBERON:0002199!5.20e-10!45;UBERON:0002416!5.20e-10!45;UBERON:0002097!6.59e-10!40;UBERON:0000467!9.80e-10!625;UBERON:0000480!1.79e-09!626;UBERON:0004290!3.62e-09!70;UBERON:0004923!5.02e-09!57;UBERON:0005156!3.13e-08!59;UBERON:0000990!3.13e-08!59;UBERON:0001134!3.92e-08!61;UBERON:0002036!3.92e-08!61;UBERON:0003082!3.92e-08!61;UBERON:0002385!4.34e-08!63;UBERON:0001015!4.34e-08!63;UBERON:0000383!4.34e-08!63;UBERON:0000490!4.64e-08!138;UBERON:0003134!1.15e-07!37;UBERON:0000474!1.15e-07!37;UBERON:0003100!1.42e-07!41;UBERON:0004119!2.00e-07!169;UBERON:0000925!2.00e-07!169;UBERON:0006595!2.00e-07!169;UBERON:0000483!2.28e-07!309;UBERON:0000119!3.30e-07!312;UBERON:0000161!5.09e-07!35
}}

Latest revision as of 12:10, 17 September 2013


Full id: C2662_Fibroblast_mesenchymal_cervical_leiomyoma_Smooth_Mesothelial_Olfactory



Phase1 CAGE Peaks

Hg19::chr2:151326054..151326068,-p@chr2:151326054..151326068
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Hg19::chr2:151326151..151326158,-p@chr2:151326151..151326158
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Hg19::chr2:151326734..151326756,-p@chr2:151326734..151326756
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Hg19::chr2:151344172..151344187,-p1@RND3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
embryonic cell2.72e-18250
fibroblast5.93e-1576
electrically responsive cell2.86e-0961
electrically active cell2.86e-0961
muscle precursor cell3.83e-0958
myoblast3.83e-0958
multi-potent skeletal muscle stem cell3.83e-0958
epithelial cell4.14e-09253
non-terminally differentiated cell6.06e-09106
smooth muscle cell1.89e-0843
smooth muscle myoblast1.89e-0843
animal cell2.99e-08679
eukaryotic cell2.99e-08679
muscle cell3.96e-0855
skin fibroblast4.75e-0823
mesodermal cell7.03e-08121
ectodermal cell6.24e-0772
mesothelial cell6.96e-0719
Uber Anatomy
Ontology termp-valuen
surface structure4.50e-1899
organism subdivision1.19e-12264
multi-cellular organism1.34e-10656
multilaminar epithelium1.45e-1083
organ component layer1.95e-1066
integument4.15e-1046
integumental system4.15e-1046
skin of body4.68e-1041
multi-tissue structure1.09e-09342
trunk mesenchyme1.97e-09122
mesenchyme4.28e-09160
entire embryonic mesenchyme4.28e-09160
dense mesenchyme tissue4.92e-0973
somite5.23e-0971
presomitic mesoderm5.23e-0971
presumptive segmental plate5.23e-0971
dermomyotome5.23e-0971
trunk paraxial mesoderm5.23e-0971
anatomical system5.83e-09624
anatomical group9.84e-09625
paraxial mesoderm1.13e-0872
presumptive paraxial mesoderm1.13e-0872
trunk1.28e-08199
unilaminar epithelium1.40e-08148
reproductive structure2.46e-0859
reproductive system2.46e-0859
endoderm-derived structure2.98e-08160
endoderm2.98e-08160
presumptive endoderm2.98e-08160
muscle tissue3.81e-0864
musculature3.81e-0864
musculature of body3.81e-0864
skeletal muscle tissue3.92e-0862
striated muscle tissue3.92e-0862
myotome3.92e-0862
female reproductive organ6.96e-0837
female reproductive system6.96e-0837
female organism9.00e-0841
digestive system1.97e-07145
digestive tract1.97e-07145
primitive gut1.97e-07145
orifice2.40e-0736
epithelial vesicle2.79e-0778
anatomical cluster4.24e-07373
Disease
Ontology termp-valuen
female reproductive organ cancer2.07e-0927
ovarian cancer4.08e-0914
reproductive organ cancer4.67e-0929


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.69331
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.841508
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.00636811
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.22.35545
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.11.15856
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.912459
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.21.05083
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.11.21162
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.11.78721
MA0161.10
MA0162.10.0928415
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.000248021
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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