MCL coexpression mm9:396: Difference between revisions
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{{MCL_coexpression_mm9 | 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of steroid hormone receptor signaling pathway;2.48515736428866e-05;14602,14599!GO:0030518;steroid hormone receptor signaling pathway;0.000322834473186431;14602,14599!GO:0030522;intracellular receptor-mediated signaling pathway;0.000422013907469306;14602,14599!GO:0040018;positive regulation of multicellular organism growth;0.000477728983046277;14602,14599!GO:0045927;positive regulation of growth;0.000537546397969296;14602,14599!GO:0040014;regulation of multicellular organism growth;0.00182418535003343;14602,14599!GO:0035264;multicellular organism growth;0.00215647132584364;14602,14599!GO:0046655;folic acid metabolic process;0.00592923897665471;14275!GO:0006810;transport;0.00592923897665471;14602,16493,14275,14599!GO:0051234;establishment of localization;0.00592923897665471;14602,16493,14275,14599!GO:0040008;regulation of growth;0.00592923897665471;14602,14599!GO:0051179;localization;0.00592923897665471;14602,16493,14275,14599!GO:0019870;potassium channel inhibitor activity;0.00592923897665471;16493!GO:0016520;growth hormone-releasing hormone receptor activity;0.00592923897665471;14602!GO:0015459;potassium channel regulator activity;0.00592923897665471;16493!GO:0005131;growth hormone receptor binding;0.00592923897665471;14599!GO:0060133;somatotropin secreting cell development;0.00592923897665471;14602!GO:0060126;somatotropin secreting cell differentiation;0.00657318122251631;14602!GO:0004999;vasoactive intestinal polypeptide receptor activity;0.00657318122251631;14602!GO:0060124;positive regulation of growth hormone secretion;0.00657318122251631;14602!GO:0043267;negative regulation of potassium ion transport;0.00657318122251631;16493!GO:0006620;posttranslational protein targeting to membrane;0.00657318122251631;14275!GO:0043567;regulation of insulin-like growth factor receptor signaling pathway;0.00657318122251631;14602!GO:0048878;chemical homeostasis;0.00731979991158991;14602,16493!GO:0043271;negative regulation of ion transport;0.00746522188833836;16493!GO:0008517;folic acid transporter activity;0.00746522188833836;14275!GO:0060123;regulation of growth hormone secretion;0.00746522188833836;14602!GO:0043266;regulation of potassium ion transport;0.00868725972802251;16493!GO:0046887;positive regulation of hormone secretion;0.00868725972802251;14602!GO:0046903;secretion;0.00889093507082687;14602,14275!GO:0030252;growth hormone secretion;0.00889093507082687;14602!GO:0021984;adenohypophysis development;0.00889093507082687;14602!GO:0008200;ion channel inhibitor activity;0.00889093507082687;16493!GO:0016248;channel inhibitor activity;0.00889093507082687;16493!GO:0008340;determination of adult life span;0.00953093980484191;14602!GO:0030104;water homeostasis;0.00953093980484191;14602!GO:0051183;vitamin transporter activity;0.00953093980484191;14275!GO:0051184;cofactor transporter activity;0.010333063439317;14275!GO:0018987;osmoregulation;0.010333063439317;14602!GO:0042592;homeostatic process;0.0105840667053847;14602,16493!GO:0009966;regulation of signal transduction;0.0107720578324596;14602,14599!GO:0048009;insulin-like growth factor receptor signaling pathway;0.0107934737471018;14602!GO:0051047;positive regulation of secretion;0.0111923120760308;14602!GO:0010259;multicellular organismal aging;0.0111923120760308;14602!GO:0005542;folic acid binding;0.0111923120760308;14275!GO:0006760;folic acid and derivative metabolic process;0.0120429111558723;14275!GO:0043269;regulation of ion transport;0.0128571384581254;16493!GO:0042558;pteridine and derivative metabolic process;0.013637267237792;14275!GO:0016247;channel regulator activity;0.0148072675954601;16493!GO:0007595;lactation;0.0148072675954601;14602!GO:0015457;auxiliary transport protein activity;0.0148072675954601;16493!GO:0051051;negative regulation of transport;0.016777432247842;16493!GO:0021983;pituitary gland development;0.016777432247842;14602!GO:0001633;secretin-like receptor activity;0.016777432247842;14602!GO:0005886;plasma membrane;0.0170756255971267;14602,16493,14599!GO:0045047;protein targeting to ER;0.0170756255971267;14275!GO:0046883;regulation of hormone secretion;0.0173531113338805;14602!GO:0021536;diencephalon development;0.0173531113338805;14602!GO:0005615;extracellular space;0.0179942877363719;14602,14275,14599!GO:0030879;mammary gland development;0.0184491084075961;14602!GO:0044421;extracellular region part;0.0206153037467956;14602,14275,14599!GO:0006612;protein targeting to membrane;0.0210171090287721;14275!GO:0015758;glucose transport;0.0210171090287721;14599!GO:0008645;hexose transport;0.0210171090287721;14599!GO:0030072;peptide hormone secretion;0.0210171090287721;14602!GO:0015749;monosaccharide transport;0.0210171090287721;14599!GO:0007568;aging;0.0210171090287721;14602!GO:0002790;peptide secretion;0.0213231929639771;14602!GO:0065008;regulation of biological quality;0.0213231929639771;14602,16493!GO:0005802;trans-Golgi network;0.0229825851491478;14599!GO:0007189;G-protein signaling, adenylate cyclase activating pathway;0.0247770458774296;14602!GO:0030141;secretory granule;0.0261276503101051;14599!GO:0015833;peptide transport;0.0261276503101051;14602!GO:0005126;hematopoietin/interferon-class (D200-domain) cytokine receptor binding;0.0261276503101051;14599!GO:0006767;water-soluble vitamin metabolic process;0.0261276503101051;14275!GO:0046879;hormone secretion;0.0271016582580552;14602!GO:0042391;regulation of membrane potential;0.0273998672993993;16493!GO:0035270;endocrine system development;0.0308974249675608;14602!GO:0051046;regulation of secretion;0.0330376439919835;14602!GO:0048518;positive regulation of biological process;0.0330477049552734;14602,14599!GO:0008076;voltage-gated potassium channel complex;0.0330477049552734;16493!GO:0006752;group transfer coenzyme metabolic process;0.0330477049552734;14275!GO:0007188;G-protein signaling, coupled to cAMP nucleotide second messenger;0.0332514267076892;14602!GO:0007187;G-protein signaling, coupled to cyclic nucleotide second messenger;0.0346391528393976;14602!GO:0019933;cAMP-mediated signaling;0.0354062112259137;14602!GO:0008643;carbohydrate transport;0.0357394729419819;14599!GO:0006766;vitamin metabolic process;0.0357394729419819;14275!GO:0019935;cyclic-nucleotide-mediated signaling;0.0359002829273947;14602!GO:0046483;heterocycle metabolic process;0.0371780650177166;14275!GO:0050878;regulation of body fluid levels;0.0386745083598179;14602!GO:0048609;reproductive process in a multicellular organism;0.0386745083598179;14602!GO:0032504;multicellular organism reproduction;0.0386745083598179;14602!GO:0048469;cell maturation;0.0392875422895539;14602!GO:0048732;gland development;0.0392875422895539;14602!GO:0007242;intracellular signaling cascade;0.0392875422895539;14602,14599!GO:0042445;hormone metabolic process;0.0420259705949108;14602!GO:0050794;regulation of cellular process;0.0420259705949108;14602,16493,14599!GO:0005249;voltage-gated potassium channel activity;0.0424011550696585;16493!GO:0051049;regulation of transport;0.0424750640880743;16493!GO:0003001;generation of a signal involved in cell-cell signaling;0.0435413653632095;14602!GO:0021700;developmental maturation;0.0450775106007803;14602!GO:0030900;forebrain development;0.0490137829712046;14602!|ontology_enrichment_celltype=|ontology_enrichment_disease=|ontology_enrichment_uberon=UBERON:0000007!1.66e-54!8;UBERON:0003296!1.66e-54!8;UBERON:0010133!1.66e-54!8;UBERON:0001894!8.43e-44!10;UBERON:0006222!8.43e-44!10;UBERON:0002780!8.52e-12!39;UBERON:0001890!8.52e-12!39;UBERON:0006240!8.52e-12!39;UBERON:0003080!1.62e-11!40;UBERON:0002616!4.29e-10!46;UBERON:0000955!6.83e-10!47;UBERON:0006238!6.83e-10!47;UBERON:0003056!1.64e-09!49;UBERON:0001049!5.37e-09!52;UBERON:0005068!5.37e-09!52;UBERON:0006241!5.37e-09!52;UBERON:0007135!5.37e-09!52;UBERON:0000073!1.10e-08!54;UBERON:0002368!7.20e-08!60;UBERON:0002346!2.08e-07!64;UBERON:0003075!2.08e-07!64;UBERON:0007284!2.08e-07!64;UBERON:0002530!2.65e-07!65|tfbs_overrepresentation_for_novel_motifs=0.457576,0.111156,0.133309,0.178048,0.531164,0.551286,0.254787,0.308279,0.32877,0.323789,0.221763,0.24561,0.564861,0.264234,0.271754,0,0.42315,0.876905,0.277053,0.664555,1.19315,0.153134,0.263535,0.070175,0.138033,0.285776,0.486875,0.202945,0.646362,0.353285,0.192916,0.512187,0.23475,0.221918,0.574198,0.16434,0.0618293,0.242872,0.052341,0.0410186,0.0689912,0.196576,0.411267,0.578047,0.0084282,0.508392,0.355451,0.214351,0.499056,1.08833,1.05136,0.307229,0.333099,0.641205,0.657376,0.743028,0.330626,0.664869,0.457729,0.268198,0.494318,0.845221,0.637374,0.398468,0.278491,1.10617,0.785371,1.12243,0.490165,0.979213,0.386078,0.58423,0.00424418,0.6886,0.0208952,0.401794,0.088252,0.346003,1.20472,0.113666,0.323638,0.438213,0.842599,0.861077,0.582029,0.0152094,0.00521875,1.63317,0.944781,1.2816,0.851763,0.586575,0.523661,0.0737837,0.0506699,0.380698,0.555715,0.526183,0.936209,0.761297,0.061865,0.511936,0.625103,0.408622,0.407717,0.196264,0.459578,0.211422,0.116526,0.361235,0.145352,0.626748,0.366686,0.225582,0.858505,0.240644,0.0705519,1.02142,0.424276,0.217483,0.693645,0.380657,0.287218,0.913128,0.910454,0.482363,1.33126,0.517583,0.783932,0.260855,1.48104,0.5148,0.75595,0.767443,0.879201,0.149536,0.471259,0.197578,0.832159,1.64606,1.25025,0.789841,0.804509,0.521565,0.402166,0.196898,0.358053,1.60668,0.475114,0.0717633,0.360841,0.0028093,0.642658,0.174823,0.27974,0.718834,0.30804,1.01394,0.453591,0.155206,0.841238,1.42171,0.482758,0.869484,0.39934,0.752521,0.220881,1.26906,0.0148726|tfbs_overrepresentation_jaspar=MA0003.1;0.00316887,MA0004.1;0.527785,MA0006.1;0.0769247,MA0007.1;2.94322,MA0009.1;0.535932,MA0014.1;0.0140786,MA0017.1;0.6294,MA0019.1;0.982191,MA0024.1;1.24244,MA0025.1;0.751694,MA0027.1;2.14278,MA0028.1;0.0821841,MA0029.1;0.477444,MA0030.1;0.483253,MA0031.1;0.451927,MA0038.1;0.285714,MA0040.1;0.547233,MA0041.1;0.129017,MA0042.1;0.121046,MA0043.1;0.624178,MA0046.1;1.39477,MA0048.1;0.295216,MA0050.1;0.205672,MA0051.1;0.2928,MA0052.1;0.554531,MA0055.1;0.19426,MA0056.1;0,MA0057.1;0.126887,MA0058.1;0.373672,MA0059.1;0.124358,MA0060.1;0.0417645,MA0061.1;0.0537092,MA0063.1;0,MA0066.1;0.759694,MA0067.1;0.857286,MA0068.1;0.0481248,MA0069.1;0.554839,MA0070.1;0.54606,MA0071.1;0.20507,MA0072.1;0.538403,MA0073.1;9.06081e-05,MA0074.1;0.249359,MA0076.1;0.101055,MA0077.1;0.518913,MA0078.1;0.319336,MA0081.1;0.138626,MA0083.1;0.623446,MA0084.1;1.1752,MA0087.1;0.583879,MA0088.1;0.476626,MA0089.1;0,MA0090.1;0.471234,MA0091.1;2.35142,MA0092.1;0.471747,MA0093.1;0.292081,MA0095.1;0,MA0098.1;0,MA0100.1;1.94524,MA0101.1;0.12981,MA0103.1;0.319254,MA0105.1;0.0188009,MA0106.1;0.325663,MA0107.1;0.093115,MA0108.2;0.395878,MA0109.1;0,MA0111.1;0.164756,MA0113.1;1.48395,MA0114.1;0.75813,MA0115.1;0.626759,MA0116.1;0.076822,MA0117.1;0.597086,MA0119.1;1.31557,MA0122.1;0.615314,MA0124.1;0.80652,MA0125.1;0.736412,MA0130.1;0,MA0131.1;0.372683,MA0132.1;0,MA0133.1;0,MA0135.1;2.67377,MA0136.1;0.264624,MA0139.1;0.0308792,MA0140.1;0.240513,MA0141.1;0.348672,MA0142.1;1.11899,MA0143.1;0.31603,MA0144.1;0.440414,MA0145.1;0.76606,MA0146.1;0.0528143,MA0147.1;0.0593437,MA0148.1;0.189643,MA0149.1;0.133214,MA0062.2;0.0201154,MA0035.2;0.244063,MA0039.2;0.0119437,MA0138.2;0.959075,MA0002.2;0.306205,MA0137.2;0.105829,MA0104.2;0.0366484,MA0047.2;0.285109,MA0112.2;0.522431,MA0065.2;0.327992,MA0150.1;0.168102,MA0151.1;0,MA0152.1;0.285194,MA0153.1;0.67335,MA0154.1;0.141864,MA0155.1;1.18425,MA0156.1;0.100572,MA0157.1;0.411541,MA0158.1;0,MA0159.1;0.851047,MA0160.1;0.191754,MA0161.1;0,MA0162.1;0.0108637,MA0163.1;0.203681,MA0164.1;0.264905,MA0080.2;0.31151,MA0018.2;0.749098,MA0099.2;0.947425,MA0079.2;0.00302608,MA0102.2;1.22663,MA0258.1;1.09353,MA0259.1;0.0546944,MA0442.1;0}} | ||
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|coexpression_dpi_cluster_scores_median=0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.03633934505493,0,0,0,0.0709019855629759,0.520980378552986,0.708737413072977,1.47602211572429,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |||
|gostat_on_MCL_coexpression=GO:0033143;regulation of steroid hormone receptor signaling pathway;2.48515736428866e-05;14602,14599!GO:0030518;steroid hormone receptor signaling pathway;0.000322834473186431;14602,14599!GO:0030522;intracellular receptor-mediated signaling pathway;0.000422013907469306;14602,14599!GO:0040018;positive regulation of multicellular organism growth;0.000477728983046277;14602,14599!GO:0045927;positive regulation of growth;0.000537546397969296;14602,14599!GO:0040014;regulation of multicellular organism growth;0.00182418535003343;14602,14599!GO:0035264;multicellular organism growth;0.00215647132584364;14602,14599!GO:0046655;folic acid metabolic process;0.00592923897665471;14275!GO:0006810;transport;0.00592923897665471;14602,16493,14275,14599!GO:0051234;establishment of localization;0.00592923897665471;14602,16493,14275,14599!GO:0040008;regulation of growth;0.00592923897665471;14602,14599!GO:0051179;localization;0.00592923897665471;14602,16493,14275,14599!GO:0019870;potassium channel inhibitor activity;0.00592923897665471;16493!GO:0016520;growth hormone-releasing hormone receptor activity;0.00592923897665471;14602!GO:0015459;potassium channel regulator activity;0.00592923897665471;16493!GO:0005131;growth hormone receptor binding;0.00592923897665471;14599!GO:0060133;somatotropin secreting cell development;0.00592923897665471;14602!GO:0060126;somatotropin secreting cell differentiation;0.00657318122251631;14602!GO:0004999;vasoactive intestinal polypeptide receptor activity;0.00657318122251631;14602!GO:0060124;positive regulation of growth hormone secretion;0.00657318122251631;14602!GO:0043267;negative regulation of potassium ion transport;0.00657318122251631;16493!GO:0006620;posttranslational protein targeting to membrane;0.00657318122251631;14275!GO:0043567;regulation of insulin-like growth factor receptor signaling pathway;0.00657318122251631;14602!GO:0048878;chemical homeostasis;0.00731979991158991;14602,16493!GO:0043271;negative regulation of ion transport;0.00746522188833836;16493!GO:0008517;folic acid transporter activity;0.00746522188833836;14275!GO:0060123;regulation of growth hormone secretion;0.00746522188833836;14602!GO:0043266;regulation of potassium ion transport;0.00868725972802251;16493!GO:0046887;positive regulation of hormone secretion;0.00868725972802251;14602!GO:0046903;secretion;0.00889093507082687;14602,14275!GO:0030252;growth hormone secretion;0.00889093507082687;14602!GO:0021984;adenohypophysis development;0.00889093507082687;14602!GO:0008200;ion channel inhibitor activity;0.00889093507082687;16493!GO:0016248;channel inhibitor activity;0.00889093507082687;16493!GO:0008340;determination of adult life span;0.00953093980484191;14602!GO:0030104;water homeostasis;0.00953093980484191;14602!GO:0051183;vitamin transporter activity;0.00953093980484191;14275!GO:0051184;cofactor transporter activity;0.010333063439317;14275!GO:0018987;osmoregulation;0.010333063439317;14602!GO:0042592;homeostatic process;0.0105840667053847;14602,16493!GO:0009966;regulation of signal transduction;0.0107720578324596;14602,14599!GO:0048009;insulin-like growth factor receptor signaling pathway;0.0107934737471018;14602!GO:0051047;positive regulation of secretion;0.0111923120760308;14602!GO:0010259;multicellular organismal aging;0.0111923120760308;14602!GO:0005542;folic acid binding;0.0111923120760308;14275!GO:0006760;folic acid and derivative metabolic process;0.0120429111558723;14275!GO:0043269;regulation of ion transport;0.0128571384581254;16493!GO:0042558;pteridine and derivative metabolic process;0.013637267237792;14275!GO:0016247;channel regulator activity;0.0148072675954601;16493!GO:0007595;lactation;0.0148072675954601;14602!GO:0015457;auxiliary transport protein activity;0.0148072675954601;16493!GO:0051051;negative regulation of transport;0.016777432247842;16493!GO:0021983;pituitary gland development;0.016777432247842;14602!GO:0001633;secretin-like receptor activity;0.016777432247842;14602!GO:0005886;plasma membrane;0.0170756255971267;14602,16493,14599!GO:0045047;protein targeting to ER;0.0170756255971267;14275!GO:0046883;regulation of hormone secretion;0.0173531113338805;14602!GO:0021536;diencephalon development;0.0173531113338805;14602!GO:0005615;extracellular space;0.0179942877363719;14602,14275,14599!GO:0030879;mammary gland development;0.0184491084075961;14602!GO:0044421;extracellular region part;0.0206153037467956;14602,14275,14599!GO:0006612;protein targeting to membrane;0.0210171090287721;14275!GO:0015758;glucose transport;0.0210171090287721;14599!GO:0008645;hexose transport;0.0210171090287721;14599!GO:0030072;peptide hormone secretion;0.0210171090287721;14602!GO:0015749;monosaccharide transport;0.0210171090287721;14599!GO:0007568;aging;0.0210171090287721;14602!GO:0002790;peptide secretion;0.0213231929639771;14602!GO:0065008;regulation of biological quality;0.0213231929639771;14602,16493!GO:0005802;trans-Golgi network;0.0229825851491478;14599!GO:0007189;G-protein signaling, adenylate cyclase activating pathway;0.0247770458774296;14602!GO:0030141;secretory granule;0.0261276503101051;14599!GO:0015833;peptide transport;0.0261276503101051;14602!GO:0005126;hematopoietin/interferon-class (D200-domain) cytokine receptor binding;0.0261276503101051;14599!GO:0006767;water-soluble vitamin metabolic process;0.0261276503101051;14275!GO:0046879;hormone secretion;0.0271016582580552;14602!GO:0042391;regulation of membrane potential;0.0273998672993993;16493!GO:0035270;endocrine system development;0.0308974249675608;14602!GO:0051046;regulation of secretion;0.0330376439919835;14602!GO:0048518;positive regulation of biological process;0.0330477049552734;14602,14599!GO:0008076;voltage-gated potassium channel complex;0.0330477049552734;16493!GO:0006752;group transfer coenzyme metabolic process;0.0330477049552734;14275!GO:0007188;G-protein signaling, coupled to cAMP nucleotide second messenger;0.0332514267076892;14602!GO:0007187;G-protein signaling, coupled to cyclic nucleotide second messenger;0.0346391528393976;14602!GO:0019933;cAMP-mediated signaling;0.0354062112259137;14602!GO:0008643;carbohydrate transport;0.0357394729419819;14599!GO:0006766;vitamin metabolic process;0.0357394729419819;14275!GO:0019935;cyclic-nucleotide-mediated signaling;0.0359002829273947;14602!GO:0046483;heterocycle metabolic process;0.0371780650177166;14275!GO:0050878;regulation of body fluid levels;0.0386745083598179;14602!GO:0048609;reproductive process in a multicellular organism;0.0386745083598179;14602!GO:0032504;multicellular organism reproduction;0.0386745083598179;14602!GO:0048469;cell maturation;0.0392875422895539;14602!GO:0048732;gland development;0.0392875422895539;14602!GO:0007242;intracellular signaling cascade;0.0392875422895539;14602,14599!GO:0042445;hormone metabolic process;0.0420259705949108;14602!GO:0050794;regulation of cellular process;0.0420259705949108;14602,16493,14599!GO:0005249;voltage-gated potassium channel activity;0.0424011550696585;16493!GO:0051049;regulation of transport;0.0424750640880743;16493!GO:0003001;generation of a signal involved in cell-cell signaling;0.0435413653632095;14602!GO:0021700;developmental maturation;0.0450775106007803;14602!GO:0030900;forebrain development;0.0490137829712046;14602! | |||
}} |
Latest revision as of 15:14, 17 September 2013
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0033143 | regulation of steroid hormone receptor signaling pathway | 2.48515736428866e-05 |
GO:0030518 | steroid hormone receptor signaling pathway | 0.000322834473186431 |
GO:0030522 | intracellular receptor-mediated signaling pathway | 0.000422013907469306 |
GO:0040018 | positive regulation of multicellular organism growth | 0.000477728983046277 |
GO:0045927 | positive regulation of growth | 0.000537546397969296 |
GO:0040014 | regulation of multicellular organism growth | 0.00182418535003343 |
GO:0035264 | multicellular organism growth | 0.00215647132584364 |
GO:0046655 | folic acid metabolic process | 0.00592923897665471 |
GO:0006810 | transport | 0.00592923897665471 |
GO:0051234 | establishment of localization | 0.00592923897665471 |
GO:0040008 | regulation of growth | 0.00592923897665471 |
GO:0051179 | localization | 0.00592923897665471 |
GO:0019870 | potassium channel inhibitor activity | 0.00592923897665471 |
GO:0016520 | growth hormone-releasing hormone receptor activity | 0.00592923897665471 |
GO:0015459 | potassium channel regulator activity | 0.00592923897665471 |
GO:0005131 | growth hormone receptor binding | 0.00592923897665471 |
GO:0060133 | somatotropin secreting cell development | 0.00592923897665471 |
GO:0060126 | somatotropin secreting cell differentiation | 0.00657318122251631 |
GO:0004999 | vasoactive intestinal polypeptide receptor activity | 0.00657318122251631 |
GO:0060124 | positive regulation of growth hormone secretion | 0.00657318122251631 |
GO:0043267 | negative regulation of potassium ion transport | 0.00657318122251631 |
GO:0006620 | posttranslational protein targeting to membrane | 0.00657318122251631 |
GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway | 0.00657318122251631 |
GO:0048878 | chemical homeostasis | 0.00731979991158991 |
GO:0043271 | negative regulation of ion transport | 0.00746522188833836 |
GO:0008517 | folic acid transporter activity | 0.00746522188833836 |
GO:0060123 | regulation of growth hormone secretion | 0.00746522188833836 |
GO:0043266 | regulation of potassium ion transport | 0.00868725972802251 |
GO:0046887 | positive regulation of hormone secretion | 0.00868725972802251 |
GO:0046903 | secretion | 0.00889093507082687 |
GO:0030252 | growth hormone secretion | 0.00889093507082687 |
GO:0021984 | adenohypophysis development | 0.00889093507082687 |
GO:0008200 | ion channel inhibitor activity | 0.00889093507082687 |
GO:0016248 | channel inhibitor activity | 0.00889093507082687 |
GO:0008340 | determination of adult life span | 0.00953093980484191 |
GO:0030104 | water homeostasis | 0.00953093980484191 |
GO:0051183 | vitamin transporter activity | 0.00953093980484191 |
GO:0051184 | cofactor transporter activity | 0.010333063439317 |
GO:0018987 | osmoregulation | 0.010333063439317 |
GO:0042592 | homeostatic process | 0.0105840667053847 |
GO:0009966 | regulation of signal transduction | 0.0107720578324596 |
GO:0048009 | insulin-like growth factor receptor signaling pathway | 0.0107934737471018 |
GO:0051047 | positive regulation of secretion | 0.0111923120760308 |
GO:0010259 | multicellular organismal aging | 0.0111923120760308 |
GO:0005542 | folic acid binding | 0.0111923120760308 |
GO:0006760 | folic acid and derivative metabolic process | 0.0120429111558723 |
GO:0043269 | regulation of ion transport | 0.0128571384581254 |
GO:0042558 | pteridine and derivative metabolic process | 0.013637267237792 |
GO:0016247 | channel regulator activity | 0.0148072675954601 |
GO:0007595 | lactation | 0.0148072675954601 |
GO:0015457 | auxiliary transport protein activity | 0.0148072675954601 |
GO:0051051 | negative regulation of transport | 0.016777432247842 |
GO:0021983 | pituitary gland development | 0.016777432247842 |
GO:0001633 | secretin-like receptor activity | 0.016777432247842 |
GO:0005886 | plasma membrane | 0.0170756255971267 |
GO:0045047 | protein targeting to ER | 0.0170756255971267 |
GO:0046883 | regulation of hormone secretion | 0.0173531113338805 |
GO:0021536 | diencephalon development | 0.0173531113338805 |
GO:0005615 | extracellular space | 0.0179942877363719 |
GO:0030879 | mammary gland development | 0.0184491084075961 |
GO:0044421 | extracellular region part | 0.0206153037467956 |
GO:0006612 | protein targeting to membrane | 0.0210171090287721 |
GO:0015758 | glucose transport | 0.0210171090287721 |
GO:0008645 | hexose transport | 0.0210171090287721 |
GO:0030072 | peptide hormone secretion | 0.0210171090287721 |
GO:0015749 | monosaccharide transport | 0.0210171090287721 |
GO:0007568 | aging | 0.0210171090287721 |
GO:0002790 | peptide secretion | 0.0213231929639771 |
GO:0065008 | regulation of biological quality | 0.0213231929639771 |
GO:0005802 | trans-Golgi network | 0.0229825851491478 |
GO:0007189 | G-protein signaling, adenylate cyclase activating pathway | 0.0247770458774296 |
GO:0030141 | secretory granule | 0.0261276503101051 |
GO:0015833 | peptide transport | 0.0261276503101051 |
GO:0005126 | hematopoietin/interferon-class (D200-domain) cytokine receptor binding | 0.0261276503101051 |
GO:0006767 | water-soluble vitamin metabolic process | 0.0261276503101051 |
GO:0046879 | hormone secretion | 0.0271016582580552 |
GO:0042391 | regulation of membrane potential | 0.0273998672993993 |
GO:0035270 | endocrine system development | 0.0308974249675608 |
GO:0051046 | regulation of secretion | 0.0330376439919835 |
GO:0048518 | positive regulation of biological process | 0.0330477049552734 |
GO:0008076 | voltage-gated potassium channel complex | 0.0330477049552734 |
GO:0006752 | group transfer coenzyme metabolic process | 0.0330477049552734 |
GO:0007188 | G-protein signaling, coupled to cAMP nucleotide second messenger | 0.0332514267076892 |
GO:0007187 | G-protein signaling, coupled to cyclic nucleotide second messenger | 0.0346391528393976 |
GO:0019933 | cAMP-mediated signaling | 0.0354062112259137 |
GO:0008643 | carbohydrate transport | 0.0357394729419819 |
GO:0006766 | vitamin metabolic process | 0.0357394729419819 |
GO:0019935 | cyclic-nucleotide-mediated signaling | 0.0359002829273947 |
GO:0046483 | heterocycle metabolic process | 0.0371780650177166 |
GO:0050878 | regulation of body fluid levels | 0.0386745083598179 |
GO:0048609 | reproductive process in a multicellular organism | 0.0386745083598179 |
GO:0032504 | multicellular organism reproduction | 0.0386745083598179 |
GO:0048469 | cell maturation | 0.0392875422895539 |
GO:0048732 | gland development | 0.0392875422895539 |
GO:0007242 | intracellular signaling cascade | 0.0392875422895539 |
GO:0042445 | hormone metabolic process | 0.0420259705949108 |
GO:0050794 | regulation of cellular process | 0.0420259705949108 |
GO:0005249 | voltage-gated potassium channel activity | 0.0424011550696585 |
GO:0051049 | regulation of transport | 0.0424750640880743 |
GO:0003001 | generation of a signal involved in cell-cell signaling | 0.0435413653632095 |
GO:0021700 | developmental maturation | 0.0450775106007803 |
GO:0030900 | forebrain development | 0.0490137829712046 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
pituitary gland | 1.66e-54 | 8 |
gland of diencephalon | 1.66e-54 | 8 |
neuroendocrine gland | 1.66e-54 | 8 |
diencephalon | 8.43e-44 | 10 |
future diencephalon | 8.43e-44 | 10 |
regional part of forebrain | 8.52e-12 | 39 |
forebrain | 8.52e-12 | 39 |
future forebrain | 8.52e-12 | 39 |
anterior neural tube | 1.62e-11 | 40 |
regional part of brain | 4.29e-10 | 46 |
brain | 6.83e-10 | 47 |
future brain | 6.83e-10 | 47 |
pre-chordal neural plate | 1.64e-09 | 49 |
neural tube | 5.37e-09 | 52 |
neural rod | 5.37e-09 | 52 |
future spinal cord | 5.37e-09 | 52 |
neural keel | 5.37e-09 | 52 |
regional part of nervous system | 1.10e-08 | 54 |
endocrine gland | 7.20e-08 | 60 |
neurectoderm | 2.08e-07 | 64 |
neural plate | 2.08e-07 | 64 |
presumptive neural plate | 2.08e-07 | 64 |
gland | 2.65e-07 | 65 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 0.00316887 |
MA0004.1 | 0.527785 |
MA0006.1 | 0.0769247 |
MA0007.1 | 2.94322 |
MA0009.1 | 0.535932 |
MA0014.1 | 0.0140786 |
MA0017.1 | 0.6294 |
MA0019.1 | 0.982191 |
MA0024.1 | 1.24244 |
MA0025.1 | 0.751694 |
MA0027.1 | 2.14278 |
MA0028.1 | 0.0821841 |
MA0029.1 | 0.477444 |
MA0030.1 | 0.483253 |
MA0031.1 | 0.451927 |
MA0038.1 | 0.285714 |
MA0040.1 | 0.547233 |
MA0041.1 | 0.129017 |
MA0042.1 | 0.121046 |
MA0043.1 | 0.624178 |
MA0046.1 | 1.39477 |
MA0048.1 | 0.295216 |
MA0050.1 | 0.205672 |
MA0051.1 | 0.2928 |
MA0052.1 | 0.554531 |
MA0055.1 | 0.19426 |
MA0056.1 | 0 |
MA0057.1 | 0.126887 |
MA0058.1 | 0.373672 |
MA0059.1 | 0.124358 |
MA0060.1 | 0.0417645 |
MA0061.1 | 0.0537092 |
MA0063.1 | 0 |
MA0066.1 | 0.759694 |
MA0067.1 | 0.857286 |
MA0068.1 | 0.0481248 |
MA0069.1 | 0.554839 |
MA0070.1 | 0.54606 |
MA0071.1 | 0.20507 |
MA0072.1 | 0.538403 |
MA0073.1 | 9.06081e-05 |
MA0074.1 | 0.249359 |
MA0076.1 | 0.101055 |
MA0077.1 | 0.518913 |
MA0078.1 | 0.319336 |
MA0081.1 | 0.138626 |
MA0083.1 | 0.623446 |
MA0084.1 | 1.1752 |
MA0087.1 | 0.583879 |
MA0088.1 | 0.476626 |
MA0089.1 | 0 |
MA0090.1 | 0.471234 |
MA0091.1 | 2.35142 |
MA0092.1 | 0.471747 |
MA0093.1 | 0.292081 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 1.94524 |
MA0101.1 | 0.12981 |
MA0103.1 | 0.319254 |
MA0105.1 | 0.0188009 |
MA0106.1 | 0.325663 |
MA0107.1 | 0.093115 |
MA0108.2 | 0.395878 |
MA0109.1 | 0 |
MA0111.1 | 0.164756 |
MA0113.1 | 1.48395 |
MA0114.1 | 0.75813 |
MA0115.1 | 0.626759 |
MA0116.1 | 0.076822 |
MA0117.1 | 0.597086 |
MA0119.1 | 1.31557 |
MA0122.1 | 0.615314 |
MA0124.1 | 0.80652 |
MA0125.1 | 0.736412 |
MA0130.1 | 0 |
MA0131.1 | 0.372683 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 2.67377 |
MA0136.1 | 0.264624 |
MA0139.1 | 0.0308792 |
MA0140.1 | 0.240513 |
MA0141.1 | 0.348672 |
MA0142.1 | 1.11899 |
MA0143.1 | 0.31603 |
MA0144.1 | 0.440414 |
MA0145.1 | 0.76606 |
MA0146.1 | 0.0528143 |
MA0147.1 | 0.0593437 |
MA0148.1 | 0.189643 |
MA0149.1 | 0.133214 |
MA0062.2 | 0.0201154 |
MA0035.2 | 0.244063 |
MA0039.2 | 0.0119437 |
MA0138.2 | 0.959075 |
MA0002.2 | 0.306205 |
MA0137.2 | 0.105829 |
MA0104.2 | 0.0366484 |
MA0047.2 | 0.285109 |
MA0112.2 | 0.522431 |
MA0065.2 | 0.327992 |
MA0150.1 | 0.168102 |
MA0151.1 | 0 |
MA0152.1 | 0.285194 |
MA0153.1 | 0.67335 |
MA0154.1 | 0.141864 |
MA0155.1 | 1.18425 |
MA0156.1 | 0.100572 |
MA0157.1 | 0.411541 |
MA0158.1 | 0 |
MA0159.1 | 0.851047 |
MA0160.1 | 0.191754 |
MA0161.1 | 0 |
MA0162.1 | 0.0108637 |
MA0163.1 | 0.203681 |
MA0164.1 | 0.264905 |
MA0080.2 | 0.31151 |
MA0018.2 | 0.749098 |
MA0099.2 | 0.947425 |
MA0079.2 | 0.00302608 |
MA0102.2 | 1.22663 |
MA0258.1 | 1.09353 |
MA0259.1 | 0.0546944 |
MA0442.1 | 0 |