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{{Coexpression_clusters
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|coexpression_dpi_cluster_scores_median=0,0,

Latest revision as of 14:19, 17 September 2013


Full id: C4782_small_gastrointestinal_medulloblastoma_Hodgkin_hepatoblastoma_anaplastic_acute



Phase1 CAGE Peaks

Hg19::chr8:95907993..95908004,+p6@C8orf38
Hg19::chr8:95908020..95908035,+p3@C8orf38
Hg19::chr8:95908044..95908055,+p4@C8orf38


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
nucleate cell4.89e-1155
lymphocyte1.99e-1053
common lymphoid progenitor1.99e-1053
lymphoid lineage restricted progenitor cell4.05e-1052
Uber Anatomy
Ontology termp-valuen
neural tube3.65e-0856
neural rod3.65e-0856
future spinal cord3.65e-0856
neural keel3.65e-0856
regional part of nervous system9.92e-0853
regional part of brain9.92e-0853
brain1.09e-0768
future brain1.09e-0768
nervous system2.17e-0789
brain grey matter4.65e-0734
gray matter4.65e-0734
organ system subdivision5.93e-07223
Disease
Ontology termp-valuen
cancer1.32e-37235
disease of cellular proliferation8.62e-36239
cell type cancer3.76e-24143
carcinoma4.76e-21106
organ system cancer5.88e-19137
hematologic cancer7.67e-1651
immune system cancer7.67e-1651
leukemia5.29e-1439
myeloid leukemia2.01e-1131


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.0927
MA0004.10.826076
MA0006.11.5435
MA0007.10.804807
MA0009.11.3275
MA0014.10.377374
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.12.13518
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.715722
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.11.80901
MA0113.12.29491
MA0114.10.549955
MA0115.11.57693
MA0116.13.4624
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.11.96087
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.11.16674
MA0147.12.37462
MA0148.11.98824
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.757898
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.21.2307
MA0047.22.23118
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.12.30945
MA0155.10.256269
MA0156.10.669101
MA0157.12.47657
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.11.2663
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.09178
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066435.360256373075030.0064925092527670.0281567633024555
E2F1#186934.907389214879320.008460985347239390.0328070112745623
E2F6#187635.017155731697390.00791769806886330.0324662924465651
ELF1#199734.258097958807540.01295179875054610.0465283747147868
ETS1#211339.728760922202340.001085840092584840.00765881363067925
FOS#235338.99795530889440.001372499272417130.00902376150531776
FOXA1#3169311.08141974938550.000734755275698670.0058461912417106
FOXA2#3170324.63046375266526.68983856509345e-050.00107754480243645
GABPB1#255337.067683836182170.002832212825417420.0154922471729833
HDAC2#3066313.41562023662630.0004140761399857210.00393930570085341
IRF1#365937.63716375356390.002244692747297240.0128823753069006
MAX#414936.452555509007120.003721913834265510.0187530373859926
MXI1#460139.96157162875930.001011470541259020.00723838370964444
MYC#460935.22228187160940.007020843755740150.0296346401408781
NFYA#4800318.42558069983050.0001598135507814160.00200345305846361
NFYB#4801316.75979325353650.0002123649923296180.00246846827311219
PBX3#5090321.91451268674419.49854535978121e-050.00137436766255222
RFX5#5993312.04791082719510.0005717246050312580.00486954379586198
SIN3A#2594235.408884726815140.006318961977991520.0278528771005088
SP1#666735.69838137814090.005403962701712170.0248091986726501
ZBTB7A#5134137.35190930787590.002516255860282270.0141067822101036



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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