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Coexpression cluster:C2157: Difference between revisions

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|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000486!2.95e-21!82;UBERON:0005256!2.38e-20!143;UBERON:0004290!3.07e-20!70;UBERON:0000914!3.29e-20!83;UBERON:0002329!3.29e-20!83;UBERON:0003077!3.29e-20!83;UBERON:0003059!3.29e-20!83;UBERON:0007282!3.29e-20!83;UBERON:0009618!3.29e-20!83;UBERON:0007285!3.29e-20!83;UBERON:0002049!3.54e-19!79;UBERON:0007798!3.54e-19!79;UBERON:0000490!3.97e-19!138;UBERON:0002100!8.72e-19!216;UBERON:0003914!1.64e-18!118;UBERON:0003104!1.66e-18!238;UBERON:0009142!1.66e-18!238;UBERON:0001134!4.96e-17!61;UBERON:0002036!4.96e-17!61;UBERON:0003082!4.96e-17!61;UBERON:0004872!1.50e-16!84;UBERON:0000055!4.74e-16!69;UBERON:0001981!7.27e-16!60;UBERON:0007500!7.27e-16!60;UBERON:0004537!7.27e-16!60;UBERON:0006965!7.27e-16!60;UBERON:0002385!1.28e-15!63;UBERON:0001015!1.28e-15!63;UBERON:0000383!1.28e-15!63;UBERON:0001637!1.71e-14!42;UBERON:0003509!1.71e-14!42;UBERON:0004572!1.71e-14!42;UBERON:0000119!2.35e-12!312;UBERON:0004535!4.60e-12!110;UBERON:0000483!1.17e-11!309;UBERON:0001009!3.00e-11!113;UBERON:0000481!1.46e-10!347;UBERON:0004573!3.31e-10!33;UBERON:0004571!3.31e-10!33;UBERON:0004211!1.93e-07!16;UBERON:0001285!1.93e-07!16;UBERON:0007684!1.93e-07!16;UBERON:0003220!1.93e-07!16;UBERON:0004208!1.93e-07!16;UBERON:0000487!2.39e-07!22;UBERON:0000475!2.87e-07!365;UBERON:0001986!3.08e-07!18;UBERON:0004638!3.08e-07!18;UBERON:0004852!3.08e-07!18;UBERON:0006914!6.03e-07!25;UBERON:0000353!7.51e-07!17
|ontology_enrichment_uberon=UBERON:0000486!2.95e-21!82;UBERON:0005256!2.38e-20!143;UBERON:0004290!3.07e-20!70;UBERON:0000914!3.29e-20!83;UBERON:0002329!3.29e-20!83;UBERON:0003077!3.29e-20!83;UBERON:0003059!3.29e-20!83;UBERON:0007282!3.29e-20!83;UBERON:0009618!3.29e-20!83;UBERON:0007285!3.29e-20!83;UBERON:0002049!3.54e-19!79;UBERON:0007798!3.54e-19!79;UBERON:0000490!3.97e-19!138;UBERON:0002100!8.72e-19!216;UBERON:0003914!1.64e-18!118;UBERON:0003104!1.66e-18!238;UBERON:0009142!1.66e-18!238;UBERON:0001134!4.96e-17!61;UBERON:0002036!4.96e-17!61;UBERON:0003082!4.96e-17!61;UBERON:0004872!1.50e-16!84;UBERON:0000055!4.74e-16!69;UBERON:0001981!7.27e-16!60;UBERON:0007500!7.27e-16!60;UBERON:0004537!7.27e-16!60;UBERON:0006965!7.27e-16!60;UBERON:0002385!1.28e-15!63;UBERON:0001015!1.28e-15!63;UBERON:0000383!1.28e-15!63;UBERON:0001637!1.71e-14!42;UBERON:0003509!1.71e-14!42;UBERON:0004572!1.71e-14!42;UBERON:0000119!2.35e-12!312;UBERON:0004535!4.60e-12!110;UBERON:0000483!1.17e-11!309;UBERON:0001009!3.00e-11!113;UBERON:0000481!1.46e-10!347;UBERON:0004573!3.31e-10!33;UBERON:0004571!3.31e-10!33;UBERON:0004211!1.93e-07!16;UBERON:0001285!1.93e-07!16;UBERON:0007684!1.93e-07!16;UBERON:0003220!1.93e-07!16;UBERON:0004208!1.93e-07!16;UBERON:0000487!2.39e-07!22;UBERON:0000475!2.87e-07!365;UBERON:0001986!3.08e-07!18;UBERON:0004638!3.08e-07!18;UBERON:0004852!3.08e-07!18;UBERON:0006914!6.03e-07!25;UBERON:0000353!7.51e-07!17
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}}
}}

Revision as of 18:03, 8 August 2012


Full id: C2157_Mallassezderived_Smooth_Alveolar_Bronchial_Keratocytes_Tracheal_mesothelioma



Phase1 CAGE Peaks

Hg19::chr11:6704513..6704578,-p1@MRPL17
Hg19::chr12:120720030..120720046,+p1@NME2P1
Hg19::chr16:67880820..67880844,+p1@NUTF2
Hg19::chr17:49243792..49243828,+p2@NME1-NME2
p2@NME2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0031967organelle envelope0.0286527553894789
GO:0031975envelope0.0286527553894789
GO:0006228UTP biosynthetic process0.0286527553894789
GO:0046051UTP metabolic process0.0286527553894789
GO:0004550nucleoside diphosphate kinase activity0.0286527553894789
GO:0046036CTP metabolic process0.0286527553894789
GO:0009209pyrimidine ribonucleoside triphosphate biosynthetic process0.0286527553894789
GO:0009208pyrimidine ribonucleoside triphosphate metabolic process0.0286527553894789
GO:0006241CTP biosynthetic process0.0286527553894789
GO:0006183GTP biosynthetic process0.0286527553894789
GO:0046039GTP metabolic process0.0286527553894789
GO:0009220pyrimidine ribonucleotide biosynthetic process0.0286527553894789
GO:0009218pyrimidine ribonucleotide metabolic process0.0286527553894789
GO:0009147pyrimidine nucleoside triphosphate metabolic process0.032089061554363
GO:0006221pyrimidine nucleotide biosynthetic process0.032089061554363
GO:0031090organelle membrane0.0353004691211007
GO:0006220pyrimidine nucleotide metabolic process0.0353004691211007
GO:0016776phosphotransferase activity, phosphate group as acceptor0.0353004691211007
GO:0005643nuclear pore0.0393385481596267
GO:0019205nucleobase, nucleoside, nucleotide kinase activity0.0393385481596267
GO:0046930pore complex0.0393385481596267
GO:0044249cellular biosynthetic process0.0393385481596267
GO:0044453nuclear membrane part0.0393385481596267
GO:0009206purine ribonucleoside triphosphate biosynthetic process0.0393385481596267
GO:0009145purine nucleoside triphosphate biosynthetic process0.0393385481596267
GO:0009201ribonucleoside triphosphate biosynthetic process0.0393385481596267
GO:0009142nucleoside triphosphate biosynthetic process0.0393385481596267
GO:0009205purine ribonucleoside triphosphate metabolic process0.0393385481596267
GO:0009144purine nucleoside triphosphate metabolic process0.0393385481596267
GO:0009199ribonucleoside triphosphate metabolic process0.0393385481596267
GO:0009152purine ribonucleotide biosynthetic process0.0393385481596267
GO:0009141nucleoside triphosphate metabolic process0.0393385481596267
GO:0031965nuclear membrane0.0393385481596267
GO:0009150purine ribonucleotide metabolic process0.0393385481596267
GO:0009260ribonucleotide biosynthetic process0.0393385481596267
GO:0006164purine nucleotide biosynthetic process0.0393385481596267
GO:0006163purine nucleotide metabolic process0.0393385481596267
GO:0009259ribonucleotide metabolic process0.0393385481596267
GO:0009058biosynthetic process0.0393385481596267
GO:0005635nuclear envelope0.0438641156314734



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
embryonic cell1.26e-38248
animal cell1.13e-31679
eukaryotic cell1.13e-31679
mesodermal cell1.32e-28119
epithelial cell3.27e-26254
non-terminally differentiated cell8.81e-25180
contractile cell1.56e-2059
electrically responsive cell3.21e-1960
electrically active cell3.21e-1960
muscle precursor cell1.06e-1857
myoblast1.06e-1857
multi-potent skeletal muscle stem cell1.06e-1857
muscle cell2.16e-1854
native cell1.61e-16722
smooth muscle cell5.86e-1642
smooth muscle myoblast5.86e-1642
somatic cell3.28e-15591
vascular associated smooth muscle cell1.45e-1332
squamous epithelial cell7.51e-1062
lining cell8.80e-1057
barrier cell8.80e-1057
meso-epithelial cell2.77e-0844
ectodermal cell1.02e-0771
endothelial cell1.11e-0735
epithelial cell of nephron1.93e-0716
blood vessel endothelial cell3.08e-0718
embryonic blood vessel endothelial progenitor cell3.08e-0718
endothelial cell of vascular tree5.34e-0724
Uber Anatomy
Ontology termp-valuen
multilaminar epithelium2.95e-2182
trunk mesenchyme2.38e-20143
dermomyotome3.07e-2070
somite3.29e-2083
paraxial mesoderm3.29e-2083
presomitic mesoderm3.29e-2083
presumptive segmental plate3.29e-2083
trunk paraxial mesoderm3.29e-2083
presumptive paraxial mesoderm3.29e-2083
vasculature3.54e-1979
vascular system3.54e-1979
unilaminar epithelium3.97e-19138
trunk8.72e-19216
epithelial tube1.64e-18118
mesenchyme1.66e-18238
entire embryonic mesenchyme1.66e-18238
skeletal muscle tissue4.96e-1761
striated muscle tissue4.96e-1761
myotome4.96e-1761
splanchnic layer of lateral plate mesoderm1.50e-1684
vessel4.74e-1669
blood vessel7.27e-1660
epithelial tube open at both ends7.27e-1660
blood vasculature7.27e-1660
vascular cord7.27e-1660
muscle tissue1.28e-1563
musculature1.28e-1563
musculature of body1.28e-1563
artery1.71e-1442
arterial blood vessel1.71e-1442
arterial system1.71e-1442
cell layer2.35e-12312
cardiovascular system4.60e-12110
epithelium1.17e-11309
circulatory system3.00e-11113
multi-tissue structure1.46e-10347
systemic artery3.31e-1033
systemic arterial system3.31e-1033
nephron epithelium1.93e-0716
nephron1.93e-0716
uriniferous tubule1.93e-0716
metanephric mesenchyme1.93e-0716
nephrogenic mesenchyme1.93e-0716
simple squamous epithelium2.39e-0722
organism subdivision2.87e-07365
endothelium3.08e-0718
blood vessel endothelium3.08e-0718
cardiovascular system endothelium3.08e-0718
squamous epithelium6.03e-0725
parenchyma7.51e-0717


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.