Coexpression cluster:C1451

Full id: C1451_immature_Sebocyte_squamous_Keratinocyte_Corneal_Small_Urothelial

Phase1 CAGE Peaks

Hg19::chr19:3136918..3136931,-	p@chr19:3136918..3136931 -
Hg19::chr1:153321301..153321325,-	p1@PGLYRP4
Hg19::chr1:24646263..24646277,+	p4@GRHL3
Hg19::chr1:27188807..27188826,+	p@chr1:27188807..27188826 +
Hg19::chr1:6550625..6550646,-	p3@PLEKHG5
Hg19::chr20:33880219..33880234,-	p1@FAM83C

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	0.00976204444926934
GO:0016019	peptidoglycan receptor activity	0.00976204444926934
GO:0009253	peptidoglycan catabolic process	0.00976204444926934
GO:0000270	peptidoglycan metabolic process	0.00976204444926934
GO:0050830	defense response to Gram-positive bacterium	0.00976204444926934
GO:0016045	detection of bacterium	0.00976204444926934
GO:0042834	peptidoglycan binding	0.00976204444926934
GO:0008329	pattern recognition receptor activity	0.0113880460240682
GO:0009595	detection of biotic stimulus	0.0118091301495636
GO:0009581	detection of external stimulus	0.0379177019804636

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
endo-epithelial cell	2.39e-31	42
endodermal cell	3.71e-22	58
epithelial cell	3.75e-21	253
respiratory epithelial cell	1.67e-19	13
epithelial cell of alimentary canal	1.04e-15	20
general ecto-epithelial cell	2.95e-15	14
epithelial cell of tracheobronchial tree	6.90e-12	9
epithelial cell of lower respiratory tract	6.90e-12	9
acinar cell	2.35e-11	5
transitional epithelial cell	1.07e-09	4
urothelial cell	1.07e-09	4
protein secreting cell	2.24e-09	6
squamous epithelial cell	1.03e-08	63
gingival epithelial cell	4.18e-08	3
bronchial epithelial cell	5.13e-08	3
duct epithelial cell	8.61e-08	3
branched duct epithelial cell	8.61e-08	3
tracheal epithelial cell	8.61e-08	3
tracheoblast	8.61e-08	3
epithelial cell of Malassez	2.80e-07	3
ecto-epithelial cell	3.06e-07	34
acinar cell of salivary gland	5.99e-07	3

Uber Anatomy

Ontology term	p-value	n
respiratory system	5.30e-18	74
endoderm-derived structure	1.56e-15	160
endoderm	1.56e-15	160
presumptive endoderm	1.56e-15	160
oral opening	6.05e-14	22
orifice	6.01e-13	36
surface structure	6.86e-13	99
respiratory tract	4.96e-12	54
mouth	1.54e-11	29
stomodeum	1.54e-11	29
urothelium	2.40e-11	5
anterior region of body	4.87e-11	62
craniocervical region	4.87e-11	62
mucosa	7.32e-11	20
tracheobronchial tree	1.34e-10	15
lower respiratory tract	1.34e-10	15
mouth mucosa	9.22e-10	13
transitional epithelium	2.28e-09	6
head	2.48e-09	56
digestive system	4.51e-09	145
digestive tract	4.51e-09	145
primitive gut	4.51e-09	145
neck	7.07e-09	10
segment of respiratory tract	8.27e-09	47
mucosa of oral region	1.51e-08	4
respiratory system mucosa	1.51e-08	4
pharynx	2.54e-08	11
gingival epithelium	4.18e-08	3
lower respiratory tract epithelium	5.13e-08	3
epithelium of bronchus	5.13e-08	3
thoracic cavity element	5.27e-08	34
thoracic cavity	5.27e-08	34
trachea	7.80e-08	7
respiratory airway	7.80e-08	7
thoracic segment organ	1.09e-07	35
subdivision of head	1.23e-07	49
tongue	3.32e-07	3
gustatory system	3.32e-07	3
future tongue	3.32e-07	3
respiratory system epithelium	5.26e-07	28
organism subdivision	7.16e-07	264
chordate pharynx	7.17e-07	10
pharyngeal region of foregut	7.17e-07	10

Disease

Ontology term	p-value	n
squamous cell carcinoma	6.55e-19	14

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.