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Coexpression cluster:C3726: Difference between revisions

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|tf_chipseq_enrich=BHLHE40#8553;2:29.9145423646516:0.00146748352710614:0.00939569103037265!E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0325136819736675!FOSL2#2355;2:11.2868004030411:0.010053458697312:0.0376726049617367!YY1#7528;3:4.91117074985386:0.00844145534180826:0.0329207301883164
|tf_chipseq_enrich=BHLHE40#8553;2:29.9145423646516:0.00146748352710614:0.00939569103037265!E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0325136819736675!FOSL2#2355;2:11.2868004030411:0.010053458697312:0.0376726049617367!YY1#7528;3:4.91117074985386:0.00844145534180826:0.0329207301883164
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|tfbs_overrepresentation_for_novel_motifs=0.699513,0.442617,0.690871,0.855819,0.641468,0.853988,0.937929,0.494933,0.491742,0.63186,0.820209,0.985163,0.436625,0.925331,0.639839,0.667627,1.17594,0.575162,0.452865,0.305559,0.69094,0.680949,0.845342,0.635379,0.743951,1.00973,0.409304,0.842925,0.645155,0.388328,0.795576,1.21459,0.534793,0.439574,0.599922,0.137917,1.45286,0.855276,0.567465,0.469078,0.598234,0.777097,0.259059,0.63803,0.901413,0.726632,0.939121,0.808003,0.247669,0.645308,1.02504,0.951993,0.336258,1.29475,1.45259,0.928548,0.650353,0.892517,0.388177,0.891404,1.25741,0.941709,0.492369,1.14672,0.961293,1.11026,1.54311,1.91674,1.2037,1.75271,0.762094,0.502203,1.5923,1.45054,1.10051,0.414196,0.396746,1.12884,1.20029,0.73687,0.459024,2.58159,0.960908,0.498519,1.39759,1.55552,0.82001,0.381882,1.053,2.0169,1.63834,1.36973,1.23218,0.543775,1.54991,0.560075,0.450952,1.27663,1.05794,0.360456,0.569121,1.22626,1.27082,1.1798,1.09802,0.815119,1.16312,0.921547,0.743661,0.622396,0.703975,1.26794,0.684398,0.830777,1.58942,0.594137,1.05469,0.794219,1.10778,0.547323,1.44203,1.0504,0.850918,0.973172,1.70203,1.12965,0.930979,1.2374,1.48578,0.561252,1.37044,0.798812,1.50051,0.969553,1.65144,0.974093,0.788803,0.843556,1.60823,2.47382,2.06967,1.57016,0.932872,1.27296,1.09989,0.883164,1.08214,2.31409,0.773313,0.539692,0.318511,1.99724,1.37083,1.21015,0.941179,1.78371,1.03563,0.624795,0.744018,0.710709,1.56892,1.35169,1.19946,0.714443,1.11698,0.960047,0.524529,0.936473,7.14564
}}
}}

Revision as of 16:19, 26 November 2012


Full id: C3726_CD34_CD4_Natural_CD14_CD8_CD133_CD14CD16



Phase1 CAGE Peaks

Hg19::chr18:48556964..48556972,-p@chr18:48556964..48556972
-
Hg19::chr21:43430591..43430653,+p@chr21:43430591..43430653
+
Hg19::chr2:113033617..113033657,-p@chr2:113033617..113033657
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte5.72e-23136
hematopoietic lineage restricted progenitor cell3.22e-19120
nongranular leukocyte4.79e-19115
hematopoietic stem cell1.17e-18168
angioblastic mesenchymal cell1.17e-18168
hematopoietic cell1.61e-18177
hematopoietic oligopotent progenitor cell4.61e-16161
hematopoietic multipotent progenitor cell4.61e-16161
connective tissue cell1.77e-13361
mesenchymal cell2.15e-13354
classical monocyte6.14e-1342
CD14-positive, CD16-negative classical monocyte6.14e-1342
motile cell1.31e-12386
defensive cell5.49e-1148
phagocyte5.49e-1148
lymphoid lineage restricted progenitor cell7.27e-1152
lymphocyte2.73e-1053
common lymphoid progenitor2.73e-1053
nucleate cell5.32e-1055
stem cell6.27e-10441
myeloid leukocyte6.69e-1072
granulocyte monocyte progenitor cell1.03e-0967
multi fate stem cell3.31e-09427
macrophage dendritic cell progenitor6.46e-0961
somatic stem cell7.33e-09433
myeloid lineage restricted progenitor cell2.63e-0866
monopoietic cell4.30e-0859
monocyte4.30e-0859
monoblast4.30e-0859
promonocyte4.30e-0859
intermediate monocyte1.49e-079
CD14-positive, CD16-positive monocyte1.49e-079
myeloid cell3.20e-07108
common myeloid progenitor3.20e-07108
B cell3.24e-0714
mature alpha-beta T cell3.59e-0718
alpha-beta T cell3.59e-0718
immature T cell3.59e-0718
mature T cell3.59e-0718
immature alpha-beta T cell3.59e-0718
Uber Anatomy
Ontology termp-valuen
connective tissue5.99e-13371
hematopoietic system9.48e-1198
blood island9.48e-1198
bone marrow1.98e-0976
bone element1.50e-0882
hemolymphoid system1.62e-08108
immune system5.00e-0793
skeletal element8.70e-0790


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BHLHE40#8553229.91454236465160.001467483527106140.00939569103037265
E2F1#186934.907389214879320.008460985347239390.0325136819736675
FOSL2#2355211.28680040304110.0100534586973120.0376726049617367
YY1#752834.911170749853860.008441455341808260.0329207301883164



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.