MCL coexpression mm9:317

Phase1 CAGE Peaks

	Short description
Mm9::chr10:128180889..128180901,-	p5@Dgka
Mm9::chr10:128181070..128181141,-	p1@Dgka
Mm9::chr10:62706636..62706712,+	p1@Herc4
Mm9::chr11:60591033..60591065,+	p1@Smcr8
Mm9::chr12:4599798..4599893,+	p1@Itsn2
Mm9::chr12:52930268..52930344,-	p1@Hectd1
Mm9::chr12:72116953..72117050,+	p1@Arid4a
Mm9::chr13:55312285..55312319,+	p4@Nsd1
Mm9::chr17:21625946..21626024,+	p1@Zfp53
Mm9::chr18:10182126..10182149,-	p5@Rock1
Mm9::chr18:10610046..10610114,-	p1@Esco1
Mm9::chr2:28980663..28980698,+	p1@Setx
Mm9::chr3:19957802..19957857,+	p1@Hltf
Mm9::chr4:100937841..100937859,-	p2@Jak1
Mm9::chr4:134486861..134486912,+	p1@Syf2
Mm9::chr4:142752000..142752037,-	p@chr4:142752000..142752037 -
Mm9::chr4:44769481..44769554,+	p1@Zcchc7
Mm9::chr6:85911625..85911665,-	p1@Dusp11
Mm9::chr6:85911666..85911677,-	p4@Dusp11
Mm9::chr7:106289578..106289659,-	p1@Uvrag
Mm9::chr7:99818398..99818422,-	p1@Pcf11
Mm9::chr8:26212579..26212641,-	p2@Plekha2
Mm9::chr9:110434942..110434971,+	p3@Setd2
Mm9::chr9:20449170..20449233,-	p1@Fbxl12
Mm9::chr9:70390679..70390727,+	p1@Sltm

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0043283	biopolymer metabolic process	0.045164440216554
GO:0006259	DNA metabolic process	0.045164440216554
GO:0006281	DNA repair	0.045164440216554
GO:0030331	estrogen receptor binding	0.045164440216554
GO:0046966	thyroid hormone receptor binding	0.045164440216554
GO:0046975	histone lysine N-methyltransferase activity (H3-K36 specific)	0.045164440216554
GO:0019992	diacylglycerol binding	0.045164440216554

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
endoderm-derived structure	9.14e-13	118
endoderm	9.14e-13	118
presumptive endoderm	9.14e-13	118
digestive system	1.25e-12	116
digestive tract	1.25e-12	116
primitive gut	1.25e-12	116
subdivision of digestive tract	2.75e-12	114
mixed endoderm/mesoderm-derived structure	5.45e-11	35
hemopoietic organ	1.10e-09	29
immune organ	1.10e-09	29
respiratory system	3.91e-09	42
endo-epithelium	5.09e-09	69
respiratory tract	9.35e-09	41
gland of gut	1.17e-08	24
pharynx	1.71e-08	24
upper respiratory tract	1.71e-08	24
chordate pharynx	1.71e-08	24
pharyngeal arch system	1.71e-08	24
pharyngeal region of foregut	1.71e-08	24
thymus	2.93e-08	23
neck	2.93e-08	23
respiratory system epithelium	2.93e-08	23
hemolymphoid system gland	2.93e-08	23
pharyngeal epithelium	2.93e-08	23
thymic region	2.93e-08	23
pharyngeal gland	2.93e-08	23
entire pharyngeal arch endoderm	2.93e-08	23
thymus primordium	2.93e-08	23
early pharyngeal endoderm	2.93e-08	23
foregut	4.22e-08	80
hemolymphoid system	5.54e-08	48
immune system	5.54e-08	48
adult organism	9.08e-08	51
hematopoietic system	3.24e-07	45
blood island	3.24e-07	45
gut epithelium	6.19e-07	55
segment of respiratory tract	6.69e-07	27

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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