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MCL coexpression mm9:440

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Phase1 CAGE Peaks

 Short description
Mm9::chr10:80962341..80962353,-p@chr10:80962341..80962353
-
Mm9::chr14:103379325..103379344,+p@chr14:103379325..103379344
+
Mm9::chr16:91406066..91406089,+p9@Il10rb
Mm9::chr18:62316324..62316329,-p@chr18:62316324..62316329
-
Mm9::chr19:32329718..32329755,+p@chr19:32329718..32329755
+
Mm9::chr1:130602320..130602335,+p@chr1:130602320..130602335
+
Mm9::chr1:87505064..87505089,+p@chr1:87505064..87505089
+
Mm9::chr1:89523255..89523265,+p@chr1:89523255..89523265
+
Mm9::chr1:89749728..89749742,-p@chr1:89749728..89749742
-
Mm9::chr4:130470264..130470268,+p@chr4:130470264..130470268
+
Mm9::chr5:108117177..108117198,+p@chr5:108117177..108117198
+
Mm9::chr5:65883638..65883674,-p@chr5:65883638..65883674
-
Mm9::chr5:73194336..73194339,+p@chr5:73194336..73194339
+
Mm9::chr5:99765762..99765773,+p@chr5:99765762..99765773
+
Mm9::chr7:25230809..25230816,+p@chr7:25230809..25230816
+
Mm9::chr8:26178393..26178407,-p@chr8:26178393..26178407
-
Mm9::chr9:107904389..107904396,+p@chr9:107904389..107904396
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0004920interleukin-10 receptor activity0.000986139264778393
GO:0019969interleukin-10 binding0.000986139264778393
GO:0004907interleukin receptor activity0.0118336711773407
GO:0019965interleukin binding0.0118336711773407
GO:0019838growth factor binding0.0118336711773407
GO:0007596blood coagulation0.0118336711773407
GO:0007599hemostasis0.0118336711773407
GO:0004896hematopoietin/interferon-class (D200-domain) cytokine receptor activity0.0118336711773407
GO:0050817coagulation0.0118336711773407
GO:0019955cytokine binding0.0125508633699068
GO:0050878regulation of body fluid levels0.0125508633699068
GO:0042060wound healing0.0129841669862488
GO:0009611response to wounding0.043693555116335



Relative expression of the co-expression cluster over median <br>Analyst:





Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic cell6.13e-1932
hematopoietic oligopotent progenitor cell6.13e-1932
hematopoietic stem cell6.13e-1932
angioblastic mesenchymal cell6.13e-1932
hematopoietic multipotent progenitor cell6.13e-1932
common myeloid progenitor1.23e-1219
connective tissue cell1.69e-1246
mesenchymal cell1.69e-1246
stem cell6.07e-1297
hematopoietic lineage restricted progenitor cell1.05e-1125
megakaryocyte progenitor cell3.07e-116
megakaryocyte3.07e-116
motile cell2.58e-1054
myeloid cell9.34e-0916
somatic stem cell1.23e-0891
multi fate stem cell1.23e-0891
lymphoid lineage restricted progenitor cell4.68e-0812
CD4-positive, alpha-beta T cell8.64e-088
megakaryocyte-erythroid progenitor cell1.58e-079
lymphocyte2.02e-0713
common lymphoid progenitor2.02e-0713
mature alpha-beta T cell6.12e-079
alpha-beta T cell6.12e-079
immature T cell6.12e-079
mature T cell6.12e-079
immature alpha-beta T cell6.12e-079

Uber Anatomy
Ontology termp-valuen
connective tissue1.69e-1246
musculoskeletal system3.68e-0932
bone marrow9.34e-0916

Disease
Ontology termp-valuen
musculoskeletal system cancer2.41e-133
muscle cancer2.41e-133
organ system cancer6.80e-076


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs




JASPAR motifs


Motifs-log10(p-value)

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