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Coexpression cluster:C2981

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Full id: C2981_maxillary_testicular_testis_renal_keratoacanthoma_liposarcoma_breast



Phase1 CAGE Peaks

Hg19::chr10:115939008..115939073,+p1@TDRD1
Hg19::chr10:115939074..115939093,+p3@TDRD1
Hg19::chr10:115992287..115992296,+p@chr10:115992287..115992296
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism7.48e-22115
ectoderm-derived structure1.87e-11169
ectoderm4.03e-11173
presumptive ectoderm4.03e-11173
anterior region of body5.44e-11129
craniocervical region5.44e-11129
regional part of brain1.62e-1059
neural tube1.11e-0957
neural rod1.11e-0957
future spinal cord1.11e-0957
neural keel1.11e-0957
head1.49e-09123
central nervous system2.62e-0982
regional part of forebrain4.26e-0941
forebrain4.26e-0941
future forebrain4.26e-0941
anterior neural tube1.07e-0842
gray matter4.96e-0834
brain grey matter4.96e-0834
cerebral hemisphere5.10e-0832
brain5.48e-0869
future brain5.48e-0869
telencephalon7.58e-0834
regional part of nervous system9.59e-0894
nervous system9.59e-0894
mouth2.37e-0728
stomodeum2.37e-0728
regional part of telencephalon2.89e-0733
regional part of cerebral cortex4.49e-0722


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.