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Coexpression cluster:C4464

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Full id: C4464_anaplastic_Prostate_esophagus_Smooth_glassy_cervical_biphenotypic



Phase1 CAGE Peaks

Hg19::chr5:134369905..134369972,-p1@PITX1
Hg19::chr5:134369973..134369984,-p3@PITX1
Hg19::chr5:134370033..134370042,-p5@PITX1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
epithelial cell1.32e-19254
endodermal cell8.69e-1759
endo-epithelial cell2.20e-1643
epithelial cell of alimentary canal1.32e-0921
respiratory epithelial cell4.95e-0713
Uber Anatomy
Ontology termp-valuen
endoderm-derived structure1.14e-28169
endoderm1.14e-28169
presumptive endoderm1.14e-28169
digestive system1.29e-26155
digestive tract1.29e-26155
primitive gut1.29e-26155
subdivision of digestive tract5.76e-23129
endodermal part of digestive tract5.76e-23129
mixed endoderm/mesoderm-derived structure7.36e-20130
respiratory system2.16e-1672
orifice4.64e-1435
foregut3.40e-1398
mesenchyme4.63e-13238
entire embryonic mesenchyme4.63e-13238
respiratory tract1.93e-1153
respiratory primordium2.53e-1138
endoderm of foregut2.53e-1138
endo-epithelium3.15e-1182
segment of respiratory tract3.86e-1146
epithelial bud1.95e-0937
surface structure4.23e-0995
hindgut5.93e-0919
organ segment8.37e-0997
oral opening2.81e-0821
thoracic segment organ4.28e-0835
thoracic cavity element4.43e-0834
thoracic cavity4.43e-0834
mouth4.52e-0828
stomodeum4.52e-0828
multi-tissue structure1.03e-07347
mucosa1.59e-0712
epithelial fold2.05e-0751
cloaca2.67e-0714
anal region2.67e-0714
embryonic cloaca2.67e-0714
terminal part of digestive tract2.67e-0714
primitive urogenital sinus2.67e-0714
proctodeum2.67e-0714
Disease
Ontology termp-valuen
cancer1.52e-30235
disease of cellular proliferation6.60e-30239
cell type cancer6.98e-28143
carcinoma2.01e-26106
organ system cancer1.68e-07137
squamous cell carcinoma2.28e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTBP2#1488362.71700033932814.049570681927e-060.000130253499368578
E2F1#186934.907389214879320.008460985347239390.0327062272810843
E2F4#1874312.66806031528440.0004917987006298980.00438400174932451
E2F6#187635.017155731697390.00791769806886330.0323811124491528
EGR1#195834.988179094810140.008056488137383440.0321997460709575
ZBTB7A#5134137.35190930787590.002516255860282270.0140720345805633
ZNF263#1012738.221841637010680.001799043925565870.0109890249469046



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.