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Coexpression cluster:C1388

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Full id: C1388_immature_CD14_Basophils_Mast_CD133_Peripheral_Natural



Phase1 CAGE Peaks

Hg19::chr14:104094662..104094670,+p@chr14:104094662..104094670
+
Hg19::chr19:1021505..1021517,+p1@ENST00000384627
Hg19::chr19:4832054..4832058,+p@chr19:4832054..4832058
+
Hg19::chr19:58695085..58695128,-p@chr19:58695085..58695128
-
Hg19::chr2:153032078..153032096,+p@chr2:153032078..153032096
+
Hg19::chr2:178128451..178128470,+p@chr2:178128451..178128470
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte4.63e-28140
CD14-positive, CD16-negative classical monocyte2.26e-2742
hematopoietic stem cell1.23e-24172
angioblastic mesenchymal cell1.23e-24172
classical monocyte6.82e-2445
hematopoietic oligopotent progenitor cell1.04e-21165
hematopoietic multipotent progenitor cell1.04e-21165
hematopoietic cell1.22e-21182
nongranular leukocyte1.36e-20119
hematopoietic lineage restricted progenitor cell1.78e-20124
myeloid leukocyte4.19e-2076
granulocyte monocyte progenitor cell3.93e-1871
myeloid cell7.61e-17112
common myeloid progenitor7.61e-17112
macrophage dendritic cell progenitor9.28e-1765
monopoietic cell1.16e-1563
monocyte1.16e-1563
monoblast1.16e-1563
promonocyte1.16e-1563
myeloid lineage restricted progenitor cell1.28e-1570
connective tissue cell6.00e-11365
mesenchymal cell1.19e-10358
native cell8.12e-10722
animal cell2.01e-09679
eukaryotic cell2.01e-09679
multi fate stem cell2.68e-09430
somatic cell3.48e-09591
stem cell3.68e-09444
somatic stem cell4.18e-09436
motile cell3.92e-08390
intermediate monocyte5.55e-079
CD14-positive, CD16-positive monocyte5.55e-079
Uber Anatomy
Ontology termp-valuen
bone marrow1.72e-1780
bone element2.15e-1586
hematopoietic system7.61e-15102
blood island7.61e-15102
hemolymphoid system1.60e-13112
skeletal element8.87e-12101
skeletal system8.87e-12101
connective tissue7.46e-11375
immune system2.42e-10115
lateral plate mesoderm1.22e-09216
musculoskeletal system3.26e-07167


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL3#602211.51570093457940.01162725346801640.0424772185863355
BDP1#558141175.0255681818180.00569994366159920.0257003158517359
BRF2#552901179.0959302325580.005570700836719840.0252100885989333
CCNT2#90544.224134384641760.007109805478875810.0296092580910882
CTCF#1066443.573504248716680.01316635007238510.0466018380455427
E2F1#186954.089491012399440.001749817597761990.0107581797899961
EBF1#187945.937644564379340.001975153636421710.0114901727084191
ELF1#199753.548414965672950.003446837775721690.0175294259085799
FOSL2#235538.465100302280850.003598315634615090.0182225906300522
HEY1#2346264.040111043105710.0002298968555807510.00253111930212925
MEF2C#4208213.77045149754130.008235596942270060.0324658403749573
NFKB1#479043.658708949462560.01207927289015230.043828070503565
PAX5#507955.557971275981520.0003977176196612860.00388634267213745
POLR2A#543062.147453176558070.01019570676818780.0380146877713315
POLR3G#106221362.4058823529410.002756203817184890.0151152683502926
SIN3A#2594254.507403939012610.001096110061208640.0076593495706255
SMARCB1#659839.126357890578710.002900247150367020.0156771860740738
STAT3#677447.012976664769490.001045723664135530.0073928338021154
TAF1#687263.343046285745290.0007162474284635620.00572948569097013
TCF12#693835.317232451093210.013367345733860.0472444068053672
TRIM28#1015539.295262522631260.00275136505059490.0150911094227762
ZBTB33#10009210.55490834332710.01374250737140590.0483869505549949
ZBTB7A#5134144.901272871917260.004079628118843750.0194864981067424



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.