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Coexpression cluster:C1587

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Full id: C1587_CD14CD16_Basophils_CD14_Natural_Eosinophils_Peripheral_CD8



Phase1 CAGE Peaks

Hg19::chr10:60026744..60026760,-p@chr10:60026744..60026760
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Hg19::chr11:82905634..82905658,-p@chr11:82905634..82905658
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Hg19::chr17:81039606..81039613,-p@chr17:81039606..81039613
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Hg19::chr17:81039627..81039643,-p@chr17:81039627..81039643
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Hg19::chr3:56792677..56792690,-p@chr3:56792677..56792690
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
CD14-positive, CD16-negative classical monocyte5.68e-3042
leukocyte1.76e-29140
classical monocyte7.69e-2845
myeloid leukocyte3.20e-2676
hematopoietic stem cell4.72e-24172
angioblastic mesenchymal cell4.72e-24172
hematopoietic cell2.31e-23182
hematopoietic lineage restricted progenitor cell7.45e-23124
nongranular leukocyte1.83e-22119
hematopoietic oligopotent progenitor cell1.13e-21165
hematopoietic multipotent progenitor cell1.13e-21165
granulocyte monocyte progenitor cell5.77e-2171
macrophage dendritic cell progenitor8.90e-2065
myeloid lineage restricted progenitor cell1.96e-1970
monopoietic cell6.49e-1963
monocyte6.49e-1963
monoblast6.49e-1963
promonocyte6.49e-1963
myeloid cell6.59e-18112
common myeloid progenitor6.59e-18112
mesenchymal cell4.57e-16358
connective tissue cell2.42e-15365
motile cell2.84e-13390
stem cell2.75e-11444
somatic stem cell3.40e-11436
multi fate stem cell4.19e-11430
intermediate monocyte1.32e-089
CD14-positive, CD16-positive monocyte1.32e-089
blood cell2.13e-0811
granulocyte1.96e-078
Uber Anatomy
Ontology termp-valuen
hematopoietic system9.41e-22102
blood island9.41e-22102
bone marrow2.00e-1980
bone element4.71e-1986
hemolymphoid system7.55e-17112
connective tissue4.51e-16375
skeletal element9.48e-16101
skeletal system9.48e-16101
immune system9.39e-11115
musculoskeletal system2.71e-07167


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.