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Coexpression cluster:C1587

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Full id: C1587_CD14CD16_Basophils_CD14_Natural_Eosinophils_Peripheral_CD8



Phase1 CAGE Peaks

  Short description
Hg19::chr10:60026744..60026760,- p@chr10:60026744..60026760
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Hg19::chr11:82905634..82905658,- p@chr11:82905634..82905658
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Hg19::chr17:81039606..81039613,- p@chr17:81039606..81039613
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Hg19::chr17:81039627..81039643,- p@chr17:81039627..81039643
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Hg19::chr3:56792677..56792690,- p@chr3:56792677..56792690
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Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
myeloid leukocyte6.34e-8072
classical monocyte6.24e-7542
CD14-positive, CD16-negative classical monocyte6.24e-7542
defensive cell1.70e-6448
phagocyte1.70e-6448
leukocyte8.81e-64136
myeloid lineage restricted progenitor cell2.37e-5966
granulocyte monocyte progenitor cell2.44e-5867
monopoietic cell1.43e-5659
monocyte1.43e-5659
monoblast1.43e-5659
promonocyte1.43e-5659
macrophage dendritic cell progenitor1.85e-5461
myeloid cell1.85e-52108
common myeloid progenitor1.85e-52108
hematopoietic stem cell1.67e-51168
angioblastic mesenchymal cell1.67e-51168
nongranular leukocyte1.11e-48115
hematopoietic cell2.73e-48177
hematopoietic oligopotent progenitor cell1.80e-47161
hematopoietic multipotent progenitor cell1.80e-47161
hematopoietic lineage restricted progenitor cell9.21e-46120
intermediate monocyte5.20e-329
CD14-positive, CD16-positive monocyte5.20e-329
stuff accumulating cell8.65e-3287
granulocyte1.86e-218
mesenchymal cell3.92e-19354
connective tissue cell1.59e-18361
motile cell2.22e-16386
blood cell2.69e-1511
stem cell8.69e-14441
multi fate stem cell9.30e-14427
somatic stem cell2.14e-13433
non-classical monocyte7.90e-123
CD14-low, CD16-positive monocyte7.90e-123
basophil1.01e-113
natural killer cell1.83e-113
pro-NK cell1.83e-113
single nucleate cell5.69e-113
mononuclear cell5.69e-113
eosinophil2.02e-082
somatic cell4.18e-07588
Uber Anatomy
Ontology termp-valuen
bone marrow2.08e-5076
bone element4.44e-4682
hematopoietic system1.61e-4498
blood island1.61e-4498
skeletal element3.39e-4190
immune system1.40e-3993
hemolymphoid system1.62e-39108
skeletal system3.49e-36100
musculoskeletal system4.71e-18167
connective tissue1.08e-17371
lateral plate mesoderm1.61e-16203
mesoderm5.55e-08315
mesoderm-derived structure5.55e-08315
presumptive mesoderm5.55e-08315


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00991994
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.161847
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.569896
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.288856
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.791444
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.13.88786
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.412364
MA0089.10
MA0090.10.556637
MA0091.11.52322
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.18.61746
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.11.40074
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.868598
MA0146.10.0359558
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.0575907
MA0138.20.837782
MA0002.20.83106
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.20.136971
MA0065.20.449243
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.12.98611
MA0155.10.409315
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.0592265
MA0163.10.0439995
MA0164.10.810347
MA0080.22.01584
MA0018.20.781393
MA0099.20.699641
MA0079.20.00732454
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
GATA3#2625210.89460654288240.0125158291218830.0452736449729961
MYC#460944.177825497287520.005691969036823440.0256676836889812
SMARCC1#6599217.46534372785260.005008037385199390.023374795158779



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.