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Coexpression cluster:C3068

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Full id: C3068_epidermoid_pharyngeal_aorta_amniotic_chorionic_Hep2_mature



Phase1 CAGE Peaks

Hg19::chr11:101980791..101980865,+p4@YAP1
Hg19::chr11:101981127..101981164,+p2@YAP1
Hg19::chr11:101981169..101981187,+p1@YAP1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
fibroblast2.70e-1275
non-terminally differentiated cell1.52e-11180
endodermal cell3.87e-0859
skin fibroblast6.02e-0823
epithelial cell3.74e-07254
Uber Anatomy
Ontology termp-valuen
endoderm-derived structure4.07e-22169
endoderm4.07e-22169
presumptive endoderm4.07e-22169
digestive system1.14e-19155
digestive tract1.14e-19155
primitive gut1.14e-19155
multi-tissue structure2.68e-18347
mesenchyme4.03e-17238
entire embryonic mesenchyme4.03e-17238
surface structure1.47e-1695
multi-cellular organism4.97e-16659
organism subdivision6.63e-16365
trunk5.06e-14216
mixed endoderm/mesoderm-derived structure5.94e-14130
organ3.62e-13511
subdivision of digestive tract5.26e-13129
endodermal part of digestive tract5.26e-13129
anatomical system4.23e-12625
anatomical group6.66e-12626
trunk mesenchyme1.77e-11143
primordium4.26e-11168
embryo5.07e-09612
immaterial anatomical entity7.18e-09126
orifice9.25e-0935
embryonic structure2.29e-08605
developing anatomical structure2.29e-08605
reproductive structure3.31e-0859
reproductive system3.31e-0859
germ layer3.98e-08604
embryonic tissue3.98e-08604
presumptive structure3.98e-08604
epiblast (generic)3.98e-08604
endo-epithelium5.16e-0882
respiratory system6.68e-0872
organ part7.44e-08219
larynx1.41e-079
organ component layer1.51e-0757
integument1.58e-0745
integumental system1.58e-0745
skin of body1.81e-0740
anatomical cluster1.98e-07286
gut epithelium2.02e-0754
foregut4.08e-0798


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BHLHE40#8553344.87181354697741.10603738662898e-050.000283677403296032
CEBPB#105137.971147625824820.001974187055288560.0114909503353554
E2F1#186934.907389214879320.008460985347239390.0323553457830301
E2F4#1874312.66806031528440.0004917987006298980.0043539005251408
E2F6#187635.017155731697390.00791769806886330.0320361253918338
EP300#203336.77394172622320.003216880500103790.0166841030218175
FOXA1#3169311.08141974938550.000734755275698670.00579366600518636
GATA3#2625218.15767757147070.003944546819279620.0189408977130457
MAX#414936.452555509007120.003721913834265510.0185711604288785
MXI1#460139.96157162875930.001011470541259020.00718081516270485
SMC3#9126210.02995522995520.0126656379767470.0457047392942257
TCF7L2#6934310.77017656313730.0008003181298398380.00611667948498667
TFAP2A#7020316.5186343730450.0002218033880766340.00247329959933115
TFAP2C#7022310.80922860986020.0007916746575753130.00612911116104582
TRIM28#10155318.59052504526250.0001555969297255280.0019654557019357
USF1#739136.361499277207960.00388404057290560.0189483049978367
USF2#7392312.99219738506960.0004558979393427810.00420354241079021



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.