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Coexpression cluster:C3217

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Full id: C3217_Mast_Macrophage_acute_Reticulocytes_CD14_granulocyte_Monocytederived



Phase1 CAGE Peaks

Hg19::chr12:102224578..102224667,-p1@GNPTAB
Hg19::chr4:79697495..79697538,+p1@BMP2K
Hg19::chr4:79697539..79697550,+p2@BMP2K


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0003976UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity0.00659356832303857
GO:0016780phosphotransferase activity, for other substituted phosphate groups0.0346065531136793



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
myeloid cell5.36e-33112
common myeloid progenitor5.36e-33112
hematopoietic stem cell1.94e-30172
angioblastic mesenchymal cell1.94e-30172
hematopoietic oligopotent progenitor cell4.65e-30165
hematopoietic multipotent progenitor cell4.65e-30165
hematopoietic cell1.56e-24182
granulocyte monocyte progenitor cell1.48e-2171
myeloid lineage restricted progenitor cell3.55e-2170
leukocyte1.64e-20140
myeloid leukocyte2.66e-2076
hematopoietic lineage restricted progenitor cell3.63e-19124
macrophage dendritic cell progenitor7.17e-1865
monopoietic cell5.67e-1763
monocyte5.67e-1763
monoblast5.67e-1763
promonocyte5.67e-1763
nongranular leukocyte2.52e-15119
CD14-positive, CD16-negative classical monocyte1.74e-1342
mesenchymal cell2.65e-12358
classical monocyte9.16e-1245
connective tissue cell2.36e-10365
motile cell2.43e-08390
multi fate stem cell1.81e-07430
lymphocyte of B lineage2.69e-0724
pro-B cell2.69e-0724
stem cell2.88e-07444
somatic stem cell8.06e-07436
Uber Anatomy
Ontology termp-valuen
hemolymphoid system2.38e-23112
hematopoietic system1.02e-22102
blood island1.02e-22102
bone marrow1.42e-1880
immune system8.67e-17115
bone element6.50e-1686
skeletal element8.50e-15101
skeletal system8.50e-15101
adult organism1.05e-14115
connective tissue2.15e-09375
lateral plate mesoderm2.34e-07216
Disease
Ontology termp-valuen
myeloid leukemia4.79e-0831
leukemia6.22e-0739


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0189312244862923
CTCFL#140690319.74647435897440.0001298372005551160.00171277850054008
E2F1#186934.907389214879320.008460985347239390.0323885514305734
EGR1#195834.988179094810140.008056488137383440.031929704181094
HMGN3#932438.178547723350590.001827766942164210.0108392568095332
NANOG#79923219.49651898734180.003427255648501020.0174425784646849
NRF1#4899312.21027944771090.0005492172401020010.0046973793578751
SIN3A#2594235.408884726815140.006318961977991520.0275620644010799
TFAP2A#7020316.5186343730450.0002218033880766340.00247488504779226
TFAP2C#7022310.80922860986020.0007916746575753130.00613320299402923
YY1#752834.911170749853860.008441455341808260.0328153485611223



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.