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Coexpression cluster:C4561

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Full id: C4561_mesenchymal_Preadipocyte_tenocyte_Fibroblast_Pancreatic_Neural_Smooth



Phase1 CAGE Peaks

Hg19::chr6:132722586..132722598,-p2@MOXD1
Hg19::chr6:132722599..132722600,-p3@MOXD1
Hg19::chr6:132722604..132722670,-p1@MOXD1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
organism subdivision1.14e-25365
multi-tissue structure7.93e-18347
surface structure9.76e-1695
somite3.27e-1583
paraxial mesoderm3.27e-1583
presomitic mesoderm3.27e-1583
presumptive segmental plate3.27e-1583
trunk paraxial mesoderm3.27e-1583
presumptive paraxial mesoderm3.27e-1583
dermomyotome1.76e-1370
integument9.62e-1345
integumental system9.62e-1345
trunk mesenchyme1.43e-12143
ectoderm-derived structure4.34e-12169
multilaminar epithelium1.25e-1182
ectoderm2.60e-11173
presumptive ectoderm2.60e-11173
multi-cellular organism8.25e-11659
skin of body1.10e-1040
muscle tissue1.18e-1063
musculature1.18e-1063
musculature of body1.18e-1063
skeletal muscle tissue1.97e-1061
striated muscle tissue1.97e-1061
myotome1.97e-1061
epithelium3.34e-10309
cell layer5.05e-10312
organ part8.15e-10219
anatomical system1.51e-09625
anatomical group2.00e-09626
trunk7.17e-09216
head1.35e-08123
pre-chordal neural plate3.01e-0861
anterior region of body5.94e-08129
craniocervical region5.94e-08129
cerebral hemisphere6.30e-0832
telencephalon1.05e-0734
organ1.56e-07511
regional part of telencephalon1.87e-0733
cerebral cortex2.56e-0725
pallium2.56e-0725
regional part of forebrain2.69e-0741
forebrain2.69e-0741
future forebrain2.69e-0741
mesenchyme4.39e-07238
entire embryonic mesenchyme4.39e-07238
anterior neural tube5.14e-0742
neural plate6.75e-0786
presumptive neural plate6.75e-0786
organ component layer7.08e-0757
central nervous system7.19e-0782


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066435.360256373075030.0064925092527670.0281042472686092
ZNF263#1012738.221841637010680.001799043925565870.0109999618606741



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.