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Coexpression cluster:C694

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Full id: C694_immature_Natural_CD8_CD14_Eosinophils_Basophils_CD4



Phase1 CAGE Peaks

Hg19::chr12:122229727..122229736,-p@chr12:122229727..122229736
-
Hg19::chr15:75747267..75747285,+p@chr15:75747267..75747285
+
Hg19::chr17:66233708..66233720,+p@chr17:66233708..66233720
+
Hg19::chr1:150601870..150601890,+p@chr1:150601870..150601890
+
Hg19::chr1:151966507..151966518,+p1@ENST00000432386
p1@uc001ezm.1
Hg19::chr1:19252656..19252668,-p@chr1:19252656..19252668
-
Hg19::chr1:19803947..19803962,-p@chr1:19803947..19803962
-
Hg19::chr1:19804053..19804060,+p@chr1:19804053..19804060
+
Hg19::chr1:221884484..221884492,-p@chr1:221884484..221884492
-
Hg19::chr2:70336251..70336262,+p@chr2:70336251..70336262
+
Hg19::chr4:103421745..103421751,+p@chr4:103421745..103421751
+
Hg19::chr7:23570867..23570875,+p@chr7:23570867..23570875
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte1.43e-39140
hematopoietic stem cell3.49e-33172
angioblastic mesenchymal cell3.49e-33172
hematopoietic lineage restricted progenitor cell1.10e-30124
hematopoietic oligopotent progenitor cell1.98e-29165
hematopoietic multipotent progenitor cell1.98e-29165
hematopoietic cell2.59e-29182
nongranular leukocyte6.42e-29119
myeloid leukocyte4.39e-1976
CD14-positive, CD16-negative classical monocyte5.52e-1942
classical monocyte1.20e-1845
granulocyte monocyte progenitor cell1.75e-1771
myeloid cell1.07e-15112
common myeloid progenitor1.07e-15112
myeloid lineage restricted progenitor cell1.79e-1570
macrophage dendritic cell progenitor7.16e-1565
lymphoid lineage restricted progenitor cell8.00e-1452
monopoietic cell9.99e-1463
monocyte9.99e-1463
monoblast9.99e-1463
promonocyte9.99e-1463
lymphocyte1.71e-1353
common lymphoid progenitor1.71e-1353
mature alpha-beta T cell9.46e-0918
alpha-beta T cell9.46e-0918
immature T cell9.46e-0918
mature T cell9.46e-0918
immature alpha-beta T cell9.46e-0918
T cell7.41e-0825
pro-T cell7.41e-0825
intermediate monocyte2.50e-079
CD14-positive, CD16-positive monocyte2.50e-079
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.23e-20102
blood island1.23e-20102
hemolymphoid system1.75e-17112
bone marrow2.19e-1680
bone element9.29e-1586
immune system1.71e-12115
skeletal element3.34e-11101
skeletal system3.34e-11101


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EBF1#187953.711027852737090.007149884520589760.0297263849301701



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.