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Coexpression cluster:C221

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Full id: C221_alveolar_Osteoblast_Myoblast_mesenchymal_liposarcoma_Smooth_hepatocellular



Phase1 CAGE Peaks

  Short description
Hg19::chr10:101690855..101690861,- p14@DNMBP
Hg19::chr10:101691056..101691064,- p13@DNMBP
Hg19::chr10:101691084..101691100,- p8@DNMBP
Hg19::chr10:101691101..101691115,- p7@DNMBP
Hg19::chr10:101691118..101691135,- p6@DNMBP
Hg19::chr10:101691199..101691208,- p11@DNMBP
Hg19::chr11:104005546..104005596,- p@chr11:104005546..104005596
-
Hg19::chr11:47256459..47256470,+ p@chr11:47256459..47256470
+
Hg19::chr12:20910262..20910266,- p@chr12:20910262..20910266
-
Hg19::chr12:92081022..92081033,- p@chr12:92081022..92081033
-
Hg19::chr13:24144882..24144893,+ p8@TNFRSF19
Hg19::chr13:24144896..24144956,+ p3@TNFRSF19
Hg19::chr13:24144958..24144969,+ p10@TNFRSF19
Hg19::chr14:29047309..29047323,+ p@chr14:29047309..29047323
+
Hg19::chr15:79290919..79290969,+ p@chr15:79290919..79290969
+
Hg19::chr16:11118533..11118538,+ p12@CLEC16A
Hg19::chr16:15991751..15991767,- p@chr16:15991751..15991767
-
Hg19::chr17:13574618..13574636,- p@chr17:13574618..13574636
-
Hg19::chr17:40481474..40481498,- p@chr17:40481474..40481498
-
Hg19::chr17:63511856..63511858,- p@chr17:63511856..63511858
-
Hg19::chr18:20715474..20715486,+ p4@CABLES1
Hg19::chr18:56199164..56199168,- p@chr18:56199164..56199168
-
Hg19::chr1:114430113..114430124,- p4@BCL2L15
Hg19::chr1:145683530..145683562,+ p@chr1:145683530..145683562
+
Hg19::chr1:219980111..219980117,- p@chr1:219980111..219980117
-
Hg19::chr1:246033769..246033788,- p@chr1:246033769..246033788
-
Hg19::chr20:2779140..2779150,- p9@CPXM1
Hg19::chr20:2779199..2779205,- p13@CPXM1
Hg19::chr20:2779236..2779242,- p12@CPXM1
Hg19::chr20:2779313..2779314,- p16@CPXM1
Hg19::chr2:75751179..75751194,+ p1@BC018659
Hg19::chr3:165178296..165178305,+ p@chr3:165178296..165178305
+
Hg19::chr3:165178316..165178330,+ p@chr3:165178316..165178330
+
Hg19::chr3:165178334..165178342,+ +
p@chr3:165178334..165178342
Hg19::chr3:55001120..55001131,- p6@LRTM1
Hg19::chr3:55002066..55002104,+ p@chr3:55002066..55002104
+
Hg19::chr3:55002159..55002164,+ p@chr3:55002159..55002164
+
Hg19::chr3:55002193..55002225,+ p@chr3:55002193..55002225
+
Hg19::chr3:55002230..55002244,+ p@chr3:55002230..55002244
+
Hg19::chr5:179720177..179720223,+ p1@ENST00000504573
Hg19::chr5:179757790..179757847,- p2@GFPT2
Hg19::chr5:179757851..179757870,- p4@GFPT2
Hg19::chr5:179757923..179757948,- p3@GFPT2
Hg19::chr5:81683619..81683623,+ p@chr5:81683619..81683623
+
Hg19::chr6:137314390..137314394,- p1@ENST00000418699
p1@ENST00000432330
Hg19::chr6:139013065..139013100,+ p6@FLJ46906
Hg19::chr6:73785930..73785949,- p@chr6:73785930..73785949
-
Hg19::chr6:73786593..73786601,+ p@chr6:73786593..73786601
+
Hg19::chr6:73786620..73786627,+ +
p@chr6:73786620..73786627
Hg19::chr7:40832998..40833012,+ p3@C7orf10
Hg19::chr7:40833016..40833066,+ p2@C7orf10
Hg19::chr7:43733671..43733688,- p@chr7:43733671..43733688
-
Hg19::chr7:63539651..63539654,+ p1@ENST00000430271
Hg19::chr8:123580859..123580902,- p@chr8:123580859..123580902
-
Hg19::chr8:123580905..123580931,- p@chr8:123580905..123580931
-
Hg19::chr8:123580943..123580958,- p@chr8:123580943..123580958
-
Hg19::chr8:123580969..123580991,- p@chr8:123580969..123580991
-
Hg19::chr8:123580995..123581003,- p@chr8:123580995..123581003
-
Hg19::chr8:123581008..123581037,- p@chr8:123581008..123581037
-
Hg19::chr8:32579421..32579432,+ p26@NRG1
Hg19::chr8:94870047..94870056,+ p30@PDP1
Hg19::chr9:119051028..119051054,- p1@ENST00000438048
Hg19::chr9:140350189..140350212,- p30@NELF
Hg19::chr9:140351903..140351920,- p6@NELF
Hg19::chrX:29686367..29686386,+ p@chrX:29686367..29686386
+


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


GO IDGO nameFDR corrected p-value
GO:0019887protein kinase regulator activity0.0272063216252323
GO:0051302regulation of cell division0.0272063216252323
GO:0004360glutamine-fructose-6-phosphate transaminase (isomerizing) activity0.0272063216252323
GO:0019207kinase regulator activity0.0272063216252323
GO:0030297transmembrane receptor protein tyrosine kinase activator activity0.0292212530700774
GO:0030971receptor tyrosine kinase binding0.0292212530700774
GO:0006002fructose 6-phosphate metabolic process0.0292212530700774
GO:0030296protein tyrosine kinase activator activity0.0383416067561451
GO:0005031tumor necrosis factor receptor activity0.0454285307791918
GO:0043120tumor necrosis factor binding0.0459896188608919
GO:0005035death receptor activity0.0464473247508643
GO:0016538cyclin-dependent protein kinase regulator activity0.0468274943289149
GO:0030295protein kinase activator activity0.0471480208963674



Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Uber Anatomy
Ontology termp-valuen
bronchoalveolar duct junction1.55e-982
alveolar duct1.55e-982
bronchiole1.55e-982
pulmonary alveolus epithelium2.39e-663
alveolus2.39e-663
pulmonary lobule2.39e-663
lobule2.39e-663
alveolus of lung2.39e-663
alveolar system2.39e-663
pulmonary acinus2.39e-663
alveolar sac2.39e-663
alveolar wall2.39e-663
anatomical wall6.76e-1812
tracheobronchial tree1.22e-1415
lower respiratory tract1.22e-1415
duct6.95e-1219
respiratory tract epithelium6.95e-1219
lung epithelium6.95e-1219
lung1.80e-1022
simple squamous epithelium1.80e-1022
respiratory tube1.80e-1022
respiration organ1.80e-1022
pair of lungs1.80e-1022
lung primordium1.80e-1022
lung bud1.80e-1022
epithelial sac2.15e-0925
squamous epithelium2.15e-0925
sac4.34e-0926
respiratory system epithelium1.52e-0828
thoracic cavity element2.74e-0734
thoracic cavity2.74e-0734
thoracic segment organ4.03e-0735
epithelial bud8.21e-0737
Disease
Ontology termp-valuen
lung adenocarcinoma1.55e-982
non-small cell lung carcinoma1.48e-405
bronchus cancer1.78e-297
bronchogenic carcinoma1.78e-297
lung carcinoma2.62e-239
lung cancer1.22e-1415
respiratory system cancer8.02e-1416


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.22561e-07
MA0004.10.0633124
MA0006.10.00153373
MA0007.10.0539233
MA0009.10.552171
MA0014.14.0786e-09
MA0017.10.134058
MA0019.10.682243
MA0024.10.807496
MA0025.12.12998
MA0027.11.62682
MA0028.10.0442399
MA0029.10.851273
MA0030.10.825221
MA0031.15.23095
MA0038.10.131055
MA0040.10.142775
MA0041.10.616689
MA0042.10.307238
MA0043.10.18864
MA0046.10.53628
MA0048.10.000397195
MA0050.10.308949
MA0051.10.127734
MA0052.10.144862
MA0055.16.406e-05
MA0056.10
MA0057.10.0182582
MA0058.10.0245925
MA0059.10.00419321
MA0060.10.0353014
MA0061.10.0858499
MA0063.10
MA0066.10.0323854
MA0067.10.415509
MA0068.10.00746289
MA0069.10.179575
MA0070.10.17296
MA0071.11.52137
MA0072.10.508135
MA0073.11.85467e-10
MA0074.10.0311065
MA0076.10.0294979
MA0077.10.165866
MA0078.10.217048
MA0081.10.492632
MA0083.10.193036
MA0084.10.572572
MA0087.10.504648
MA0088.10.0837254
MA0089.10
MA0090.10.381587
MA0091.10.0136404
MA0092.11.35711
MA0093.10.0375178
MA0095.10
MA0098.10
MA0100.10.142277
MA0101.10.0956677
MA0103.10.0800113
MA0105.10.00194259
MA0106.10.0430936
MA0107.10.0358425
MA0108.20.100589
MA0109.10
MA0111.10.648566
MA0113.10.405601
MA0114.10.00272901
MA0115.10.355528
MA0116.10.0134037
MA0117.10.608162
MA0119.10.44067
MA0122.10.228629
MA0124.13.27039
MA0125.10.263758
MA0130.10
MA0131.10.0664674
MA0132.10
MA0133.10
MA0135.10.207272
MA0136.11.31843
MA0139.10.000267045
MA0140.10.247279
MA0141.10.163994
MA0142.10.616519
MA0143.10.716434
MA0144.11.35562
MA0145.10.015141
MA0146.14.69067e-09
MA0147.10.00351991
MA0148.16.42539
MA0149.10.0214733
MA0062.20.00179798
MA0035.20.0999679
MA0039.27.53686e-06
MA0138.20.822995
MA0002.20.287076
MA0137.21.71945
MA0104.20.000885359
MA0047.25.00716
MA0112.20.00551258
MA0065.20.00147639
MA0150.10.840653
MA0151.10
MA0152.10.774662
MA0153.12.80401
MA0154.10.162782
MA0155.10.000635334
MA0156.10.223388
MA0157.10.560955
MA0158.10
MA0159.10.00356597
MA0160.10.218176
MA0161.10
MA0162.13.65868e-09
MA0163.12.29585e-06
MA0164.10.192509
MA0080.20.944553
MA0018.20.167041
MA0099.25.6415
MA0079.20
MA0102.20.605147
MA0258.10.587524
MA0259.10.00416583
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
JUN#3725163.080081031959713.99486758543661e-050.000741988219376515
STAT3#6774193.07492053762976.20075441492697e-060.000183196772373567
TCF7L2#6934193.148205456917074.39975432367538e-060.000137782891097551



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data