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Coexpression cluster:C3227

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Full id: C3227_Neutrophils_Whole_Reticulocytes_blood_Eosinophils_CD4_CD19



Phase1 CAGE Peaks

Hg19::chr12:106696583..106696651,+p1@TCP11L2
Hg19::chr15:43477580..43477656,+p1@CCNDBP1
Hg19::chr16:15736897..15736928,-p2@KIAA0430


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0005777peroxisome0.0440896712647909
GO:0042579microbody0.0440896712647909



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte7.07e-19140
hematopoietic lineage restricted progenitor cell5.63e-16124
nongranular leukocyte5.61e-15119
hematopoietic stem cell1.94e-11172
angioblastic mesenchymal cell1.94e-11172
myeloid leukocyte7.68e-1176
mature alpha-beta T cell8.55e-1118
alpha-beta T cell8.55e-1118
immature T cell8.55e-1118
mature T cell8.55e-1118
immature alpha-beta T cell8.55e-1118
hematopoietic oligopotent progenitor cell1.09e-10165
hematopoietic multipotent progenitor cell1.09e-10165
CD14-positive, CD16-negative classical monocyte6.78e-1042
hematopoietic cell2.21e-09182
classical monocyte2.84e-0945
myeloid lineage restricted progenitor cell2.08e-0870
lymphoid lineage restricted progenitor cell2.53e-0852
lymphocyte5.55e-0853
common lymphoid progenitor5.55e-0853
CD8-positive, alpha-beta T cell1.31e-0711
granulocyte monocyte progenitor cell3.17e-0771
macrophage dendritic cell progenitor9.06e-0765
monopoietic cell9.44e-0763
monocyte9.44e-0763
monoblast9.44e-0763
promonocyte9.44e-0763
Uber Anatomy
Ontology termp-valuen
adult organism3.02e-26115
hematopoietic system1.10e-10102
blood island1.10e-10102
hemolymphoid system1.21e-10112


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL3#602223.03140186915890.002464674760842910.0138488280705693
ELF1#199734.258097958807540.01295179875054610.0460374688485564
IRF1#365937.63716375356390.002244692747297240.0127700983677403
NFKB1#479035.488063424193840.006049381815655430.0268744475496719
SIN3A#2594235.408884726815140.006318961977991520.027566669591456
SPI1#668838.204323508522730.001810593189410520.0108838806324879



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.