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Coexpression cluster:C248

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Full id: C248_iPS_Aortic_Hep2_amygdala_acute_medial_Myoblast



Phase1 CAGE Peaks

Hg19::chr10:118316172..118316174,+p@chr10:118316172..118316174
+
Hg19::chr10:51371401..51371434,+p1@TIMM23B
Hg19::chr10:91738412..91738433,+p2@SNRPD2P1
Hg19::chr11:125937329..125937360,+p1@NAP1L1P1
Hg19::chr11:32113490..32113494,+p@chr11:32113490..32113494
+
Hg19::chr11:56457700..56457749,+p1@ENST00000530434
Hg19::chr11:74660278..74660334,+p1@SPCS2
Hg19::chr11:93268577..93268595,+p2@ENST00000533701
Hg19::chr11:93268598..93268609,+p3@ENST00000533701
Hg19::chr11:96930964..96930970,+p@chr11:96930964..96930970
+
Hg19::chr12:63396232..63396236,+p1@ENST00000546650
Hg19::chr12:6547635..6547653,+p1@ENST00000447193
Hg19::chr12:8786931..8786949,+p1@ENST00000540341
Hg19::chr16:28722774..28722807,+p1@EIF3CL
p1@EIF3C
Hg19::chr16:28722809..28722820,+p2@EIF3C
Hg19::chr16:81129886..81129900,-p2@GCSH
Hg19::chr17:64766837..64766855,+p@chr17:64766837..64766855
+
Hg19::chr18:60085536..60085538,+p@chr18:60085536..60085538
+
Hg19::chr19:47778489..47778503,+p4@PRR24
Hg19::chr1:147400526..147400541,+p1@GPR89A
p1@GPR89B
Hg19::chr1:160287068..160287094,+p1@SUMO1P3
Hg19::chr20:6194218..6194234,+p1@ENST00000434910
Hg19::chr2:202689240..202689246,+p1@ENST00000411559
Hg19::chr2:203043989..203044014,+p1@ENST00000429685
Hg19::chr2:215562319..215562343,+p1@ENSAP3
Hg19::chr2:219064995..219065012,+p2@HMGB1P9
Hg19::chr2:219065015..219065047,+p1@HMGB1P9
Hg19::chr2:26045115..26045120,+p1@ENST00000407942
Hg19::chr3:22423205..22423225,+p1@HMGB1P5
Hg19::chr3:96068204..96068231,+p1@HNRNPKP4
Hg19::chr4:11370223..11370243,+p1@MIR572
Hg19::chr4:190394055..190394060,+p1@HSP90AA4P
Hg19::chr4:68311705..68311712,+p1@ENST00000508720
Hg19::chr5:172952686..172952687,+p@chr5:172952686..172952687
+
Hg19::chr5:177302520..177302548,+p1@ENST00000506672
Hg19::chr5:31923423..31923442,+p3@ENST00000506046
Hg19::chr5:76878173..76878177,+p1@ENST00000493874
Hg19::chr6:147727578..147727589,+p1@YAP1P1
Hg19::chr6:29404662..29404683,+p@chr6:29404662..29404683
+
Hg19::chr6:34187145..34187149,+p1@CYCSP55
Hg19::chr7:10490855..10490865,+p1@ENST00000419827
Hg19::chr7:135335552..135335555,+p@chr7:135335552..135335555
+
Hg19::chr7:3740599..3740621,+p@chr7:3740599..3740621
+
Hg19::chr7:53574034..53574038,+p@chr7:53574034..53574038
+
Hg19::chr7:55799735..55799767,+p1@SUMO2P3
Hg19::chr7:5938386..5938430,+p1@CCZ1B
p1@CCZ1
Hg19::chr7:63895150..63895155,+p@chr7:63895150..63895155
+
Hg19::chr8:102381049..102381068,+p2@NACAP1
Hg19::chr8:146220249..146220272,+p1@TMED10P1
Hg19::chr8:71016502..71016506,-p1@ENST00000406023
p1@ENST00000521867
Hg19::chrX:33059434..33059464,+p2@TBCAP1
Hg19::chrX:33059467..33059499,+p1@TBCAP1
Hg19::chrX:68003226..68003229,+p1@ENST00000396021


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0005852eukaryotic translation initiation factor 3 complex0.00023297493378405
GO:0006413translational initiation0.00704921342770137
GO:0003743translation initiation factor activity0.00704921342770137
GO:0022618protein-RNA complex assembly0.00709118496049346
GO:0008135translation factor activity, nucleic acid binding0.0110468791359476
GO:0043234protein complex0.0110468791359476
GO:0005787signal peptidase complex0.0110468791359476
GO:0022613ribonucleoprotein complex biogenesis and assembly0.0110468791359476
GO:0032991macromolecular complex0.0263807899356535
GO:0009003signal peptidase activity0.0263807899356535
GO:0005744mitochondrial inner membrane presequence translocase complex0.0270512476685397
GO:0006465signal peptide processing0.0270512476685397
GO:0044444cytoplasmic part0.0333867519422573
GO:0015450P-P-bond-hydrolysis-driven protein transmembrane transporter activity0.0333867519422573
GO:0022884macromolecule transmembrane transporter activity0.0333867519422573
GO:0008320protein transmembrane transporter activity0.0333867519422573
GO:0006518peptide metabolic process0.0333867519422573
GO:0065003macromolecular complex assembly0.0446612539727981
GO:0022607cellular component assembly0.0487153428619245



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic oligopotent progenitor cell2.57e-20165
hematopoietic multipotent progenitor cell2.57e-20165
hematopoietic stem cell1.51e-19172
angioblastic mesenchymal cell1.51e-19172
myeloid cell5.46e-18112
common myeloid progenitor5.46e-18112
hematopoietic cell1.48e-17182
hematopoietic lineage restricted progenitor cell1.77e-15124
classical monocyte1.77e-1445
leukocyte2.31e-14140
CD14-positive, CD16-negative classical monocyte4.09e-1442
granulocyte monocyte progenitor cell2.40e-1371
myeloid lineage restricted progenitor cell2.53e-1370
macrophage dendritic cell progenitor5.16e-1265
myeloid leukocyte2.13e-1176
nongranular leukocyte2.30e-11119
monopoietic cell3.04e-1163
monocyte3.04e-1163
monoblast3.04e-1163
promonocyte3.04e-1163
native cell1.18e-08722
motile cell6.86e-08390
mesenchymal cell2.13e-07358
Uber Anatomy
Ontology termp-valuen
bone marrow2.02e-1280
bone element1.03e-1186
skeletal element1.86e-10101
skeletal system1.86e-10101
larynx2.27e-079
Disease
Ontology termp-valuen
cancer1.12e-09235
disease of cellular proliferation2.01e-09239


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data