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Coexpression cluster:C763

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Full id: C763_cord_B_splenic_xeroderma_b_hairy_mycosis



Phase1 CAGE Peaks

Hg19::chr17:48270438..48270450,-p2@X98708
Hg19::chr19:6586908..6586931,-p@chr19:6586908..6586931
-
Hg19::chr1:117605017..117605033,+p@chr1:117605017..117605033
+
Hg19::chr1:12125156..12125160,+p@chr1:12125156..12125160
+
Hg19::chr1:220393543..220393560,+p@chr1:220393543..220393560
+
Hg19::chr1:56797895..56797912,-p@chr1:56797895..56797912
-
Hg19::chr2:223288613..223288620,+p13@SGPP2
Hg19::chr3:121797240..121797259,-p@chr3:121797240..121797259
-
Hg19::chr3:16552074..16552079,+p@chr3:16552074..16552079
+
Hg19::chr5:169173501..169173512,+p@chr5:169173501..169173512
+
Hg19::chrX:53743451..53743487,-p@chrX:53743451..53743487
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
umbilical cord4.82e-1210
blastocyst4.82e-1210
blastula4.82e-1210
bilaminar disc4.82e-1210
inner cell mass4.82e-1210
cleaving embryo4.82e-1210
connecting stalk4.82e-1210
inner cell mass derived epiblast4.82e-1210
extraembryonic mesoderm4.82e-1210
blood3.30e-0815
haemolymphatic fluid3.30e-0815
organism substance3.30e-0815
Disease
Ontology termp-valuen
lymphoma1.54e-3010
genetic disease8.58e-141
monogenic disease8.58e-141
xeroderma pigmentosum8.58e-141
non-Hodgkin lymphoma9.73e-141
cutaneous T cell lymphoma9.73e-141
mycosis fungoides9.73e-141
anemia2.07e-131
hematologic cancer2.45e-0851
immune system cancer2.45e-0851
hematopoietic system disease2.40e-072


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#53335410.31616549222070.0004170021263392250.00392283237909767
EBF1#187997.287109238101911.25865967327101e-077.20686171144468e-06
MEF2A#420546.815720330779660.001972858993531150.0115852358968456
MEF2C#4208311.26673304344290.002021415800258610.0117468642757183
NFKB1#4790104.989148567448943.69910541950576e-071.82317541721455e-05
POLR2A#5430112.147453176558070.0002231983422387430.00248593491149323



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.