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Coexpression cluster:C1345

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Full id: C1345_Intestinal_Hepatocyte_small_testis_colon_Prostate_temporal



Phase1 CAGE Peaks

  Short description
Hg19::chr11:621862..621873,- p@chr11:621862..621873
-
Hg19::chr16:28608364..28608377,- p1@SULT1A2
Hg19::chr1:116878934..116878942,- p@chr1:116878934..116878942
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Hg19::chr1:199996859..199996870,+ p8@NR5A2
Hg19::chr6:158724401..158724405,- p@chr6:158724401..158724405
-
Hg19::chr6:52668605..52668622,- p1@GSTA1


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


p.valueFDRnGenesnPathwayName
6.15571812123322e-050.03896569570740632130Biological oxidations (Reactome):REACT_13433



Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


GO IDGO nameFDR corrected p-value
GO:0004062aryl sulfotransferase activity0.0286092712752857
GO:0006749glutathione metabolic process0.038596371797347
GO:0006584catecholamine metabolic process0.038596371797347
GO:0003705RNA polymerase II transcription factor activity, enhancer binding0.038596371797347
GO:0018958phenol metabolic process0.038596371797347



Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
metabolising cell1.34e-2412
endopolyploid cell1.34e-2412
parenchymal cell1.34e-2412
polyploid cell1.34e-2412
hepatocyte1.34e-2412
endodermal cell6.72e-1158
intestinal epithelial cell3.02e-074
Uber Anatomy
Ontology termp-valuen
intestine4.13e-3317
gastrointestinal system5.71e-3225
digestive tract diverticulum5.12e-2523
liver6.97e-2519
digestive gland6.97e-2519
liver bud6.97e-2519
epithelium of foregut-midgut junction8.58e-2325
anatomical boundary8.58e-2325
hepatobiliary system8.58e-2325
foregut-midgut junction8.58e-2325
septum transversum8.58e-2325
subdivision of digestive tract9.28e-23118
sac6.28e-2226
hepatic diverticulum2.72e-2122
liver primordium2.72e-2122
large intestine1.05e-1911
digestive system1.84e-19145
digestive tract1.84e-19145
primitive gut1.84e-19145
gut epithelium1.89e-1954
epithelial sac1.47e-1825
endoderm-derived structure3.40e-17160
endoderm3.40e-17160
presumptive endoderm3.40e-17160
colon4.12e-179
abdomen element2.29e-1654
abdominal segment element2.29e-1654
endocrine gland9.47e-1635
exocrine gland1.11e-1431
exocrine system1.11e-1431
abdominal segment of trunk1.78e-1460
abdomen1.78e-1460
endocrine system2.43e-1445
small intestine3.07e-124
endo-epithelium7.63e-1282
lower digestive tract1.79e-115
organ system subdivision7.82e-11223
gland1.41e-1059
trunk region element6.68e-09101
multi-tissue structure1.30e-08342
foregut9.30e-0887
anatomical cluster2.25e-07373
vermiform appendix2.35e-071
caecum2.35e-071
midgut2.35e-071
intestinal mucosa3.02e-074
wall of intestine3.02e-074
gastrointestinal system mucosa3.02e-074
gastrointestinal system epithelium3.02e-074
intestinal epithelium3.02e-074
rectum5.55e-074


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00461978
MA0004.10.558729
MA0006.10.391183
MA0007.10.539222
MA0009.11.03681
MA0014.10.0254709
MA0017.10.432438
MA0019.10.7124
MA0024.10.929647
MA0025.11.17262
MA0027.12.65688
MA0028.10.408079
MA0029.10.949428
MA0030.10.937696
MA0031.10.871496
MA0038.10.665566
MA0040.10.955415
MA0041.10.578072
MA0042.10.544748
MA0043.11.03713
MA0046.11.02569
MA0048.10.152639
MA0050.10.545671
MA0051.10.661179
MA0052.10.959373
MA0055.10.0586456
MA0056.10
MA0057.10.147053
MA0058.10.458909
MA0059.10.457555
MA0060.10.267412
MA0061.10.23892
MA0063.10
MA0066.10.66601
MA0067.11.35893
MA0068.13.22865
MA0069.11.02175
MA0070.11.01032
MA0071.10.625297
MA0072.11.00572
MA0073.11.53717
MA0074.10.660398
MA0076.10.475586
MA0077.10.997832
MA0078.10.763954
MA0081.10.457725
MA0083.11.04447
MA0084.11.5477
MA0087.11.00322
MA0088.10.32124
MA0089.10
MA0090.11.22966
MA0091.10.561458
MA0092.10.522012
MA0093.10.394379
MA0095.10
MA0098.10
MA0100.12.74425
MA0101.10.397846
MA0103.10.381434
MA0105.10.134725
MA0106.10.70837
MA0107.10.320267
MA0108.20.868347
MA0109.10
MA0111.10.504913
MA0113.10.725375
MA0114.10.845337
MA0115.11.28169
MA0116.10.323925
MA0117.11.07516
MA0119.10.440684
MA0122.11.10154
MA0124.11.23968
MA0125.11.15445
MA0130.10
MA0131.10.782708
MA0132.10
MA0133.10
MA0135.11.06778
MA0136.10.672893
MA0139.10.226048
MA0140.10.622527
MA0141.10.455728
MA0142.10.838805
MA0143.10.725558
MA0144.10.299851
MA0145.10.107156
MA0146.10.093337
MA0147.10.327615
MA0148.10.584698
MA0149.10.612449
MA0062.20.658749
MA0035.22.55804
MA0039.20.35955
MA0138.20.765223
MA0002.20.709311
MA0137.20.414885
MA0104.20.26661
MA0047.20.695777
MA0112.20.332548
MA0065.20.354331
MA0150.12.10974
MA0151.10
MA0152.10.629368
MA0153.11.13732
MA0154.10.132326
MA0155.10.0961854
MA0156.10.417278
MA0157.10.810597
MA0158.10
MA0159.10.328286
MA0160.11.46233
MA0161.10
MA0162.10.347838
MA0163.10.273773
MA0164.10.738243
MA0080.20.394469
MA0018.20.709805
MA0099.20.629739
MA0079.20.0318308
MA0102.21.58513
MA0258.10.289793
MA0259.10.336472
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


No analysis results for this cluster

Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.