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Coexpression cluster:C1903

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Full id: C1903_Neutrophils_Melanocyte_melanoma_large_Eosinophils_Dendritic_smallcell



Phase1 CAGE Peaks

Hg19::chr2:37571765..37571779,+p3@QPCT
Hg19::chr2:37571802..37571814,+p4@QPCT
Hg19::chr2:37571815..37571841,+p2@QPCT
Hg19::chr2:37571845..37571874,+p1@QPCT
Hg19::chr8:41435743..41435781,+p2@AGPAT6


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0008415acyltransferase activity0.000608344126535578
GO:0016747transferase activity, transferring groups other than amino-acyl groups0.000608344126535578
GO:0002065columnar/cuboidal epithelial cell differentiation0.000608344126535578
GO:0002071glandular epithelial cell maturation0.000608344126535578
GO:0016603glutaminyl-peptide cyclotransferase activity0.000608344126535578
GO:0002069columnar/cuboidal epithelial cell maturation0.000608344126535578
GO:0002068glandular epithelial cell development0.000608344126535578
GO:0002067glandular epithelial cell differentiation0.000608344126535578
GO:0002066columnar/cuboidal epithelial cell development0.000608344126535578
GO:0016746transferase activity, transferring acyl groups0.000703667072152397
GO:0019432triacylglycerol biosynthetic process0.00182495179473819
GO:0002070epithelial cell maturation0.00182495179473819
GO:0002064epithelial cell development0.00210568261513309
GO:0046460neutral lipid biosynthetic process0.00239514346295391
GO:0046339diacylglycerol metabolic process0.00239514346295391
GO:0046463acylglycerol biosynthetic process0.00239514346295391
GO:0046504glycerol ether biosynthetic process0.00243312579766239
GO:0045017glycerolipid biosynthetic process0.00243312579766239
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity0.00288124835526489
GO:0030879mammary gland development0.00383183467487036
GO:0016411acylglycerol O-acyltransferase activity0.004170581612032
GO:0006641triacylglycerol metabolic process0.00447850406949948
GO:0007595lactation0.00469135173158027
GO:0040014regulation of multicellular organism growth0.00469135173158027
GO:0006638neutral lipid metabolic process0.00469135173158027
GO:0006639acylglycerol metabolic process0.00469135173158027
GO:0035264multicellular organism growth0.00469135173158027
GO:0046486glycerolipid metabolic process0.00469135173158027
GO:0006662glycerol ether metabolic process0.0047182440534268
GO:0008374O-acyltransferase activity0.00635490193752125
GO:0030855epithelial cell differentiation0.00635490193752125
GO:0016755transferase activity, transferring amino-acyl groups0.00701083823460036
GO:0048469cell maturation0.00740257816787757
GO:0048732gland development0.00740257816787757
GO:0021700developmental maturation0.00828451589885018
GO:0048609reproductive process in a multicellular organism0.00901854013105816
GO:0032504multicellular organism reproduction0.00901854013105816
GO:0002009morphogenesis of an epithelium0.00906885145392443
GO:0016740transferase activity0.0220472389811176
GO:0006631fatty acid metabolic process0.0260704782158773
GO:0040008regulation of growth0.0267623173948116
GO:0032787monocarboxylic acid metabolic process0.0372556740871745
GO:0022414reproductive process0.0386612278681044
GO:0008610lipid biosynthetic process0.0412340501477284



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.72292
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.369468
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.14.0988
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.00220137
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.132006
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.11.58771
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.12.39477
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.13.62647
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.11.76068
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.143698
MA0146.10.333008
MA0147.10.386018
MA0148.10.653474
MA0149.13.99004
MA0062.20.284987
MA0035.20.691506
MA0039.20.311551
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.21.96224
MA0065.20.449243
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.98952
MA0155.11.3196
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.81299
MA0163.10.382496
MA0164.13.15573
MA0080.22.01584
MA0018.20.781393
MA0099.20.699641
MA0079.20.0850863
MA0102.21.66336
MA0258.10.914277
MA0259.11.02361
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
USF1#739156.361499277207969.59569864925045e-050.00136982664192054



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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