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Coexpression cluster:C2362

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Full id: C2362_Neutrophils_CD14_Whole_Eosinophils_Hepatocyte_Mesenchymal_blood



Phase1 CAGE Peaks

  Short description
Hg19::chr16:1993170..1993226,- p1@SEPX1
Hg19::chr16:1993230..1993248,- p2@SEPX1
Hg19::chr16:1993260..1993271,- p3@SEPX1
Hg19::chr19:1155118..1155189,- p@chr19:1155118..1155189
-


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
mesoderm4.93e-18315
mesoderm-derived structure4.93e-18315
presumptive mesoderm4.93e-18315
lateral plate mesoderm3.45e-15203
musculoskeletal system2.00e-14167
trunk2.98e-12199
mesenchyme1.17e-11160
entire embryonic mesenchyme1.17e-11160
trunk mesenchyme1.80e-10122
organism subdivision2.52e-10264
epithelial vesicle2.65e-1078
hemolymphoid system6.66e-09108
subdivision of trunk7.75e-09112
hematopoietic system1.64e-0898
blood island1.64e-0898
somite2.16e-0871
presomitic mesoderm2.16e-0871
presumptive segmental plate2.16e-0871
dermomyotome2.16e-0871
trunk paraxial mesoderm2.16e-0871
circulatory system2.80e-08112
dense mesenchyme tissue2.99e-0873
muscle tissue3.93e-0864
musculature3.93e-0864
musculature of body3.93e-0864
paraxial mesoderm5.31e-0872
presumptive paraxial mesoderm5.31e-0872
cardiovascular system6.23e-08109
multilaminar epithelium6.61e-0883
skeletal muscle tissue7.61e-0862
striated muscle tissue7.61e-0862
myotome7.61e-0862
epithelial tube8.81e-08117
multi-cellular organism1.51e-07656
unilaminar epithelium5.77e-07148
bone marrow5.84e-0776
anatomical group8.70e-07625
anatomical system9.79e-07624


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.8989
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.11.86845
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.396851
MA0056.10
MA0057.11.98521
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.13.49299
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.599068
MA0074.10.819248
MA0076.11.51122
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.13.89719
MA0089.10
MA0090.10.640115
MA0091.11.70187
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.12.29123
MA0103.10.521546
MA0105.11.90157
MA0106.10.869173
MA0107.12.98058
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.15.47627
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.569905
MA0146.18.33841
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.22.51225
MA0035.20.778873
MA0039.27.89088
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.21.05083
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.12.64806
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.11.57817
MA0163.16.15941
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.24.43857
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90534.752151182721970.01386206996689490.0487159541447114
E2F1#186944.907389214879320.001724022357361790.0106415585685879
EBF1#187936.679850134926750.005184294118278910.0240416719248227
FOS#235336.74846648167080.005032452776317940.0234646339348127
GABPB1#255335.300762877136630.01012678824234270.037850964041301
IRF1#365935.727872815172930.008097114790333330.0320032762483962
MAX#414934.839416631755340.01315737137836840.0466127106304414
NFYA#4800313.81918552487290.0006132411806734510.00508667267638429
NFYB#4801312.56984494015230.000811456397697350.00618686631034557
SP2#6668319.61514787038350.0002171004269245340.00248561187103391
SPI1#668836.153242631392040.006580387113059030.0280991515946019
TCF7L2#693438.077632422353010.002978381685834620.0158606569899491
ZBTB7A#5134135.513931980906920.009038352821081090.0342335725785482
ZEB1#6935312.66632401315790.000793336075912850.00613106603761005



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.