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Coexpression cluster:C3493

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Full id: C3493_Eosinophils_CD14_Neutrophils_Mast_CD14CD16_CD34_Peripheral



Phase1 CAGE Peaks

  Short description
Hg19::chr15:45879256..45879273,- p@chr15:45879256..45879273
-
Hg19::chr19:54713776..54713805,- p1@ENST00000413723
Hg19::chr3:44482076..44482098,+ p1@ENST00000500374


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
classical monocyte8.10e-7242
CD14-positive, CD16-negative classical monocyte8.10e-7242
myeloid leukocyte2.63e-6672
defensive cell1.52e-6148
phagocyte1.52e-6148
granulocyte monocyte progenitor cell1.28e-5467
leukocyte1.12e-53136
macrophage dendritic cell progenitor4.13e-5161
myeloid cell5.63e-51108
common myeloid progenitor5.63e-51108
myeloid lineage restricted progenitor cell9.24e-5066
monopoietic cell3.55e-4759
monocyte3.55e-4759
monoblast3.55e-4759
promonocyte3.55e-4759
hematopoietic stem cell5.58e-46168
angioblastic mesenchymal cell5.58e-46168
hematopoietic cell7.00e-43177
hematopoietic oligopotent progenitor cell2.03e-39161
hematopoietic multipotent progenitor cell2.03e-39161
hematopoietic lineage restricted progenitor cell8.12e-36120
nongranular leukocyte5.85e-34115
stuff accumulating cell2.12e-2987
intermediate monocyte1.07e-249
CD14-positive, CD16-positive monocyte1.07e-249
granulocyte3.75e-178
mesenchymal cell1.02e-14354
connective tissue cell3.81e-14361
blood cell3.91e-1211
motile cell3.97e-12386
multi fate stem cell1.11e-09427
stem cell1.41e-09441
somatic stem cell2.41e-09433
non-classical monocyte4.38e-093
basophil4.38e-093
CD14-low, CD16-positive monocyte4.38e-093
single nucleate cell1.01e-083
mononuclear cell1.01e-083
natural killer cell1.24e-083
pro-NK cell1.24e-083
eosinophil4.11e-072
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.68e-5398
blood island1.68e-5398
bone marrow1.58e-4976
hemolymphoid system2.26e-47108
immune system6.46e-4793
bone element4.20e-4582
skeletal element4.08e-4090
skeletal system5.33e-35100
lateral plate mesoderm2.57e-20203
musculoskeletal system1.38e-16167
connective tissue2.31e-13371
mesoderm9.60e-09315
mesoderm-derived structure9.60e-09315
presumptive mesoderm9.60e-09315


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.377374
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.11.58389
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.11.74184
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.348055
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.141
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.731309
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.0373086
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BRF2#552901358.1918604651160.002789217733358720.0152778680890676
GATA1#2623313.56030814380040.0004009615963782630.00387346481954948
SREBF1#6720231.33723296032550.00133816265136180.00887454718983841



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.