MCL coexpression mm9:2912
From FANTOM5_SSTAR
Phase1 CAGE Peaks
| Short description | |
|---|---|
| Mm9::chr14:51544691..51544702,+ | p3@Apex1 |
| Mm9::chr8:87493517..87493535,+ | p2@LOC100504815 p4@Prdx2 |
| Mm9::chr8:87493536..87493552,+ | p1@Prdx2 |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0008379 | thioredoxin peroxidase activity | 0.00701235377937627 |
| GO:0030503 | regulation of cell redox homeostasis | 0.00701235377937627 |
| GO:0051920 | peroxiredoxin activity | 0.0122699382083509 |
| GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity | 0.0122699382083509 |
| GO:0006950 | response to stress | 0.0208406163069042 |
| GO:0006800 | oxygen and reactive oxygen species metabolic process | 0.0256901280940883 |
| GO:0008430 | selenium binding | 0.0256901280940883 |
| GO:0004601 | peroxidase activity | 0.0256901280940883 |
| GO:0016684 | oxidoreductase activity, acting on peroxide as acceptor | 0.0256901280940883 |
| GO:0045454 | cell redox homeostasis | 0.0286531090740304 |
| GO:0006979 | response to oxidative stress | 0.0286531090740304 |
| GO:0016835 | carbon-oxygen lyase activity | 0.0344235690782167 |
| GO:0006916 | anti-apoptosis | 0.0419865234837695 |
| GO:0004519 | endonuclease activity | 0.0424781986506297 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| ectodermal cell | 7.85e-16 | 44 |
| neurectodermal cell | 7.85e-16 | 44 |
| neural cell | 3.23e-15 | 43 |
| non-terminally differentiated cell | 3.42e-14 | 49 |
| neuron | 1.24e-12 | 33 |
| neuronal stem cell | 1.24e-12 | 33 |
| neuroblast | 1.24e-12 | 33 |
| electrically signaling cell | 1.24e-12 | 33 |
| electrically responsive cell | 1.61e-11 | 39 |
| electrically active cell | 1.61e-11 | 39 |
| CNS neuron (sensu Vertebrata) | 2.63e-10 | 23 |
| neuroblast (sensu Vertebrata) | 2.63e-10 | 23 |
| embryonic cell | 4.34e-07 | 70 |
| Ontology term | p-value | n |
|---|---|---|
| structure with developmental contribution from neural crest | 2.33e-14 | 92 |
| central nervous system | 2.30e-12 | 73 |
| nervous system | 2.89e-12 | 75 |
| ectoderm-derived structure | 1.70e-09 | 95 |
| ectoderm | 1.70e-09 | 95 |
| presumptive ectoderm | 1.70e-09 | 95 |
| neurectoderm | 1.95e-09 | 64 |
| neural plate | 1.95e-09 | 64 |
| presumptive neural plate | 1.95e-09 | 64 |
| pre-chordal neural plate | 5.20e-08 | 49 |
| regional part of nervous system | 1.96e-07 | 54 |
| neural tube | 2.16e-07 | 52 |
| neural rod | 2.16e-07 | 52 |
| future spinal cord | 2.16e-07 | 52 |
| neural keel | 2.16e-07 | 52 |
| ecto-epithelium | 3.21e-07 | 73 |
| regional part of forebrain | 5.72e-07 | 39 |
| forebrain | 5.72e-07 | 39 |
| future forebrain | 5.72e-07 | 39 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 1.35193 |
| MA0004.1 | 3.1287 |
| MA0006.1 | 1.46714 |
| MA0007.1 | 0.784593 |
| MA0009.1 | 1.27673 |
| MA0014.1 | 0.133574 |
| MA0017.1 | 0.635031 |
| MA0019.1 | 1.08369 |
| MA0024.1 | 1.23079 |
| MA0025.1 | 1.51835 |
| MA0027.1 | 2.9431 |
| MA0028.1 | 0.61552 |
| MA0029.1 | 1.20789 |
| MA0030.1 | 1.21482 |
| MA0031.1 | 1.17722 |
| MA0038.1 | 0.963265 |
| MA0040.1 | 1.28983 |
| MA0041.1 | 0.714279 |
| MA0042.1 | 0.69885 |
| MA0043.1 | 1.3775 |
| MA0046.1 | 1.31428 |
| MA0048.1 | 0.353763 |
| MA0050.1 | 0.845669 |
| MA0051.1 | 0.973068 |
| MA0052.1 | 1.29825 |
| MA0055.1 | 0.190475 |
| MA0056.1 | 0 |
| MA0057.1 | 0.337566 |
| MA0058.1 | 5.37295 |
| MA0059.1 | 4.09028 |
| MA0060.1 | 0.502699 |
| MA0061.1 | 0.5406 |
| MA0063.1 | 0 |
| MA0066.1 | 0.951196 |
| MA0067.1 | 1.63197 |
| MA0068.1 | 0.343188 |
| MA0069.1 | 1.29861 |
| MA0070.1 | 1.28847 |
| MA0071.1 | 0.844726 |
| MA0072.1 | 1.2796 |
| MA0073.1 | 0.680038 |
| MA0074.1 | 0.911576 |
| MA0076.1 | 0.657929 |
| MA0077.1 | 1.2569 |
| MA0078.1 | 1.0091 |
| MA0081.1 | 0.732313 |
| MA0083.1 | 1.37668 |
| MA0084.1 | 1.96428 |
| MA0087.1 | 1.33189 |
| MA0088.1 | 0.27999 |
| MA0089.1 | 0 |
| MA0090.1 | 0.762482 |
| MA0091.1 | 0.816659 |
| MA0092.1 | 0.762845 |
| MA0093.1 | 5.01758 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.89873 |
| MA0101.1 | 0.71579 |
| MA0103.1 | 0.647985 |
| MA0105.1 | 0.405648 |
| MA0106.1 | 1.01755 |
| MA0107.1 | 0.640607 |
| MA0108.2 | 1.10817 |
| MA0109.1 | 0 |
| MA0111.1 | 0.778753 |
| MA0113.1 | 0.986839 |
| MA0114.1 | 0.537669 |
| MA0115.1 | 1.38041 |
| MA0116.1 | 0.602598 |
| MA0117.1 | 1.34691 |
| MA0119.1 | 4.13797 |
| MA0122.1 | 1.36752 |
| MA0124.1 | 1.57762 |
| MA0125.1 | 1.5017 |
| MA0130.1 | 0 |
| MA0131.1 | 1.07881 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 1.4152 |
| MA0136.1 | 0.933582 |
| MA0139.1 | 0.462282 |
| MA0140.1 | 0.898603 |
| MA0141.1 | 0.671467 |
| MA0142.1 | 1.16183 |
| MA0143.1 | 1.00467 |
| MA0144.1 | 0.541532 |
| MA0145.1 | 0.292366 |
| MA0146.1 | 0.151124 |
| MA0147.1 | 3.4453 |
| MA0148.1 | 0.820161 |
| MA0149.1 | 0.722227 |
| MA0062.2 | 0.412742 |
| MA0035.2 | 0.903829 |
| MA0039.2 | 1.55941 |
| MA0138.2 | 1.07027 |
| MA0002.2 | 1.17677 |
| MA0137.2 | 0.668025 |
| MA0104.2 | 3.1221 |
| MA0047.2 | 0.962424 |
| MA0112.2 | 0.29236 |
| MA0065.2 | 0.292912 |
| MA0150.1 | 0.784464 |
| MA0151.1 | 0 |
| MA0152.1 | 0.962542 |
| MA0153.1 | 1.43238 |
| MA0154.1 | 0.35067 |
| MA0155.1 | 0.840842 |
| MA0156.1 | 0.656895 |
| MA0157.1 | 1.12772 |
| MA0158.1 | 0 |
| MA0159.1 | 0.569393 |
| MA0160.1 | 0.823568 |
| MA0161.1 | 0 |
| MA0162.1 | 0.964824 |
| MA0163.1 | 0.927936 |
| MA0164.1 | 0.933981 |
| MA0080.2 | 0.64167 |
| MA0018.2 | 0.944669 |
| MA0099.2 | 1.06348 |
| MA0079.2 | 0.288542 |
| MA0102.2 | 2.01714 |
| MA0258.1 | 0.520639 |
| MA0259.1 | 1.34197 |
| MA0442.1 | 0 |
