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Coexpression cluster:C1852

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Full id: C1852_Neutrophils_CD19_CD4_Peripheral_Eosinophils_Natural_CD8



Phase1 CAGE Peaks

Hg19::chr1:227127664..227127698,-p@chr1:227127664..227127698
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Hg19::chr1:40840182..40840198,-p@chr1:40840182..40840198
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Hg19::chr1:40840233..40840259,-p@chr1:40840233..40840259
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Hg19::chr1:40851288..40851322,-p@chr1:40851288..40851322
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Hg19::chr1:40851848..40851881,+p@chr1:40851848..40851881
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte8.99e-49140
hematopoietic stem cell3.87e-48172
angioblastic mesenchymal cell3.87e-48172
hematopoietic cell2.84e-47182
hematopoietic oligopotent progenitor cell1.77e-44165
hematopoietic multipotent progenitor cell1.77e-44165
hematopoietic lineage restricted progenitor cell3.32e-38124
nongranular leukocyte7.71e-38119
lymphoid lineage restricted progenitor cell4.06e-2352
lymphocyte4.14e-2353
common lymphoid progenitor4.14e-2353
myeloid cell5.70e-21112
common myeloid progenitor5.70e-21112
myeloid leukocyte2.13e-1976
CD14-positive, CD16-negative classical monocyte4.26e-1842
classical monocyte6.24e-1745
granulocyte monocyte progenitor cell3.49e-1671
myeloid lineage restricted progenitor cell1.34e-1470
macrophage dendritic cell progenitor1.65e-1465
monopoietic cell1.46e-1363
monocyte1.46e-1363
monoblast1.46e-1363
promonocyte1.46e-1363
mature alpha-beta T cell3.86e-1218
alpha-beta T cell3.86e-1218
immature T cell3.86e-1218
mature T cell3.86e-1218
immature alpha-beta T cell3.86e-1218
lymphocyte of B lineage1.02e-1124
pro-B cell1.02e-1124
mesenchymal cell3.98e-11358
T cell9.66e-1125
pro-T cell9.66e-1125
connective tissue cell2.14e-10365
B cell3.68e-0914
CD8-positive, alpha-beta T cell5.38e-0811
motile cell7.02e-08390
Uber Anatomy
Ontology termp-valuen
hematopoietic system7.14e-23102
blood island7.14e-23102
hemolymphoid system1.08e-20112
bone marrow1.19e-1380
bone element2.64e-1286
immune system7.11e-12115
connective tissue4.26e-10375
skeletal element6.76e-09101
skeletal system6.76e-09101
blood1.37e-0815
haemolymphatic fluid1.37e-0815
organism substance1.37e-0815


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.