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Coexpression cluster:C971

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Full id: C971_CD34_immature_Mast_CD133_CD19_Natural_Basophils



Phase1 CAGE Peaks

Hg19::chr10:12375728..12375741,-p@chr10:12375728..12375741
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Hg19::chr12:90343644..90343653,-p@chr12:90343644..90343653
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Hg19::chr14:89882631..89882659,+p@chr14:89882631..89882659
+
Hg19::chr1:156074228..156074251,+p@chr1:156074228..156074251
+
Hg19::chr2:232571303..232571355,+p5@PTMA
Hg19::chr2:98280747..98280764,+p2@ENST00000450072
Hg19::chr7:100027806..100027819,-p@chr7:100027806..100027819
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Hg19::chrX:40032100..40032114,-p@chrX:40032100..40032114
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte3.72e-40136
hematopoietic stem cell8.08e-33168
angioblastic mesenchymal cell8.08e-33168
hematopoietic cell4.63e-31177
hematopoietic lineage restricted progenitor cell5.32e-31120
nongranular leukocyte1.06e-29115
hematopoietic oligopotent progenitor cell9.33e-29161
hematopoietic multipotent progenitor cell9.33e-29161
lymphoid lineage restricted progenitor cell1.24e-2252
lymphocyte5.25e-2253
common lymphoid progenitor5.25e-2253
nucleate cell8.03e-2155
B cell9.79e-1514
myeloid leukocyte2.31e-1272
lymphocyte of B lineage4.37e-1124
pro-B cell4.37e-1124
classical monocyte4.48e-1142
CD14-positive, CD16-negative classical monocyte4.48e-1142
granulocyte monocyte progenitor cell1.20e-1067
mesenchymal cell1.56e-10354
intermediate monocyte2.20e-109
CD14-positive, CD16-positive monocyte2.20e-109
myeloid cell4.91e-10108
common myeloid progenitor4.91e-10108
CD4-positive, alpha-beta T cell5.25e-106
connective tissue cell6.63e-10361
motile cell2.24e-09386
T cell2.57e-0925
pro-T cell2.57e-0925
mature alpha-beta T cell4.69e-0918
alpha-beta T cell4.69e-0918
immature T cell4.69e-0918
mature T cell4.69e-0918
immature alpha-beta T cell4.69e-0918
macrophage dendritic cell progenitor5.22e-0961
defensive cell6.09e-0948
phagocyte6.09e-0948
myeloid lineage restricted progenitor cell8.04e-0966
monopoietic cell1.65e-0759
monocyte1.65e-0759
monoblast1.65e-0759
promonocyte1.65e-0759
stem cell9.91e-07441
Uber Anatomy
Ontology termp-valuen
bone marrow4.00e-1176
hematopoietic system1.55e-1098
blood island1.55e-1098
bone element1.99e-1082
connective tissue1.60e-09371
hemolymphoid system2.88e-09108
immune system5.84e-0993
skeletal element9.73e-0990
skeletal system4.71e-07100


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F1#186953.067118259299580.01129732364974160.0414487874887712
ESR1#2099311.53822623605790.001699321616590140.0106158302616974
FOS#235344.49897765444720.007374489916227120.0304830346062235
IRF3#3661211.74548805287240.01164488049453140.0425341752865515
NFKB1#479053.430039640121150.006880907700328230.0291405506392515
POLR2A#543082.147453176558070.002210725788971910.0127287055887555
TFAP2A#702036.194487889891860.009861483862380290.0370502738723338



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.