Coexpression cluster:C144

Full id: C144_CD4_tonsil_NK_appendix_CD8_splenic_mycosis

Phase1 CAGE Peaks

Hg19::chr10:6114599..6114604,+	p@chr10:6114599..6114604 +
Hg19::chr10:75255272..75255287,-	p@chr10:75255272..75255287 -
Hg19::chr11:4111694..4111720,+	p@chr11:4111694..4111720 +
Hg19::chr11:76284493..76284520,-	p@chr11:76284493..76284520 -
Hg19::chr11:76284523..76284532,-	p@chr11:76284523..76284532 -
Hg19::chr12:50336994..50337003,+	p@chr12:50336994..50337003 +
Hg19::chr12:50337005..50337016,+	p@chr12:50337005..50337016 +
Hg19::chr12:50337021..50337036,+	p@chr12:50337021..50337036 +
Hg19::chr12:58102607..58102613,+	p@chr12:58102607..58102613 +
Hg19::chr12:58102624..58102632,+	p@chr12:58102624..58102632 +
Hg19::chr12:58102635..58102654,+	p@chr12:58102635..58102654 +
Hg19::chr12:58102662..58102674,+	p@chr12:58102662..58102674 +
Hg19::chr12:58102682..58102689,+	p@chr12:58102682..58102689 +
Hg19::chr12:99139620..99139633,-	p29@ANKS1B
Hg19::chr13:113840580..113840595,-	p11@PCID2
Hg19::chr13:73573059..73573073,+	p@chr13:73573059..73573073 +
Hg19::chr13:75890666..75890681,-	p23@TBC1D4
Hg19::chr13:75890689..75890698,-	p22@TBC1D4
Hg19::chr13:75890705..75890726,-	p8@TBC1D4
Hg19::chr13:75890730..75890751,-	p11@TBC1D4
Hg19::chr13:99966972..99966986,+	p10@UBAC2
Hg19::chr14:106069896..106069928,-	p@chr14:106069896..106069928 -
Hg19::chr14:22443217..22443229,+	p@chr14:22443217..22443229 +
Hg19::chr14:66335008..66335022,+	p@chr14:66335008..66335022 +
Hg19::chr14:66342511..66342535,+	p@chr14:66342511..66342535 +
Hg19::chr14:66384160..66384166,+	p@chr14:66384160..66384166 +
Hg19::chr14:66473382..66473386,+	p@chr14:66473382..66473386 +
Hg19::chr14:69246886..69246901,-	p@chr14:69246886..69246901 -
Hg19::chr14:69246908..69246919,-	p@chr14:69246908..69246919 -
Hg19::chr15:34628951..34628970,-	p21@SLC12A6
Hg19::chr15:38988723..38988728,+	p3@C15orf53
Hg19::chr15:38988768..38988793,+	p1@C15orf53
Hg19::chr15:38988801..38988810,+	p2@C15orf53
Hg19::chr15:38997190..38997193,+	p@chr15:38997190..38997193 +
Hg19::chr15:39142027..39142030,+	p@chr15:39142027..39142030 +
Hg19::chr15:39179946..39179951,+	p@chr15:39179946..39179951 +
Hg19::chr15:39188204..39188208,+	p@chr15:39188204..39188208 +
Hg19::chr15:39196210..39196213,+	p@chr15:39196210..39196213 +
Hg19::chr15:39260074..39260077,+	p@chr15:39260074..39260077 +
Hg19::chr15:39316251..39316255,+	p@chr15:39316251..39316255 +
Hg19::chr15:45028697..45028709,+	p10@TRIM69
Hg19::chr15:52549283..52549293,-	p5@MYO5C
Hg19::chr15:74919872..74919883,+	p@chr15:74919872..74919883 +
Hg19::chr15:91415990..91416002,+	p4@FURIN
Hg19::chr16:12633178..12633179,+	p@chr16:12633178..12633179 +
Hg19::chr16:12633181..12633216,+	p@chr16:12633181..12633216 +
Hg19::chr16:12633220..12633234,+	p@chr16:12633220..12633234 +
Hg19::chr16:3119275..3119289,+	p@chr16:3119275..3119289 +
Hg19::chr16:31265094..31265102,+	p@chr16:31265094..31265102 +
Hg19::chr16:31265115..31265130,+	p@chr16:31265115..31265130 +
Hg19::chr16:68390585..68390598,+	p@chr16:68390585..68390598 +
Hg19::chr16:68390609..68390614,+	p@chr16:68390609..68390614 +
Hg19::chr17:14023072..14023081,+	p@chr17:14023072..14023081 +
Hg19::chr17:17082930..17082936,+	p@chr17:17082930..17082936 +
Hg19::chr17:18247551..18247560,-	p@chr17:18247551..18247560 -
Hg19::chr17:18247561..18247571,-	p@chr17:18247561..18247571 -
Hg19::chr17:36853518..36853526,-	p@chr17:36853518..36853526 -
Hg19::chr17:37947726..37947743,-	p@chr17:37947726..37947743 -
Hg19::chr17:37949241..37949253,-	p@chr17:37949241..37949253 -
Hg19::chr17:37949262..37949283,-	p@chr17:37949262..37949283 -
Hg19::chr17:57905350..57905362,-	p@chr17:57905350..57905362 -
Hg19::chr19:19779686..19779697,+	p3@ZNF101
Hg19::chr19:3177362..3177366,+	p@chr19:3177362..3177366 +
Hg19::chr19:38917975..38917982,-	p@chr19:38917975..38917982 -
Hg19::chr19:38917995..38918006,-	p@chr19:38917995..38918006 -
Hg19::chr19:41963286..41963299,-	p@chr19:41963286..41963299 -
Hg19::chr19:41963314..41963323,-	p@chr19:41963314..41963323 -
Hg19::chr1:110456600..110456612,+	p19@CSF1
Hg19::chr1:112145782..112145793,-	p@chr1:112145782..112145793 -
Hg19::chr1:9000012..9000016,+	p@chr1:9000012..9000016 +
Hg19::chr20:17944380..17944396,-	p@chr20:17944380..17944396 -
Hg19::chr20:48211053..48211065,+	p@chr20:48211053..48211065 +
Hg19::chr20:48211074..48211083,+	p@chr20:48211074..48211083 +
Hg19::chr20:48211099..48211112,+	p@chr20:48211099..48211112 +
Hg19::chr20:48211124..48211159,+	p@chr20:48211124..48211159 +
Hg19::chr20:48211160..48211182,+	p@chr20:48211160..48211182 +
Hg19::chr22:46983792..46983802,+	p@chr22:46983792..46983802 +
Hg19::chr2:101967791..101967807,-	p@chr2:101967791..101967807 -
Hg19::chr2:102624993..102625009,+	p6@IL1R2
Hg19::chr2:204718100..204718122,+	p@chr2:204718100..204718122 +
Hg19::chr2:204718611..204718622,+	p@chr2:204718611..204718622 +
Hg19::chr2:204718629..204718648,+	p@chr2:204718629..204718648 +
Hg19::chr2:204718657..204718664,+	p@chr2:204718657..204718664 +
Hg19::chr2:204718667..204718689,+	p@chr2:204718667..204718689 +
Hg19::chr2:204718709..204718716,+	p@chr2:204718709..204718716 +
Hg19::chr2:204720243..204720258,+	p@chr2:204720243..204720258 +
Hg19::chr2:241976174..241976202,+	p7@SNED1
Hg19::chr2:28837255..28837277,-	p@chr2:28837255..28837277 -
Hg19::chr2:86696032..86696046,+	p@chr2:86696032..86696046 +
Hg19::chr3:194204893..194204913,+	p@chr3:194204893..194204913 +
Hg19::chr3:195018381..195018405,-	p@chr3:195018381..195018405 -
Hg19::chr3:32543051..32543061,-	p@chr3:32543051..32543061 -
Hg19::chr3:32995025..32995046,+	p1@AB464482 p1@CU687156
Hg19::chr3:33061467..33061496,+	p@chr3:33061467..33061496 +
Hg19::chr3:33063435..33063443,-	p@chr3:33063435..33063443 -
Hg19::chr3:33064076..33064077,+	p@chr3:33064076..33064077 +
Hg19::chr3:50647738..50647778,-	p@chr3:50647738..50647778 -
Hg19::chr4:90228214..90228230,-	p@chr4:90228214..90228230 -
Hg19::chr5:131878918..131878934,-	p@chr5:131878918..131878934 -
Hg19::chr5:132009675..132009687,+	p1@IL4
Hg19::chr5:66124481..66124523,-	p@chr5:66124481..66124523 -
Hg19::chr5:66124998..66125007,+	p@chr5:66124998..66125007 +
Hg19::chr5:79286163..79286172,-	p@chr5:79286163..79286172 -
Hg19::chr6:11788124..11788142,-	p@chr6:11788124..11788142 -
Hg19::chr6:149457920..149457945,-	p@chr6:149457920..149457945 -
Hg19::chr6:149523352..149523377,-	p@chr6:149523352..149523377 -
Hg19::chr6:167536230..167536251,+	p5@CCR6
Hg19::chr6:34639750..34639779,-	p5@C6orf106
Hg19::chr7:44663643..44663674,+	p4@OGDH
Hg19::chr8:38216954..38216982,-	p@chr8:38216954..38216982 -
Hg19::chr8:38216992..38217013,-	p@chr8:38216992..38217013 -
Hg19::chr9:134552199..134552210,-	p@chr9:134552199..134552210 -
Hg19::chr9:139001783..139001802,+	p@chr9:139001783..139001802 +
Hg19::chrX:49107434..49107439,-	p@chrX:49107434..49107439 -
Hg19::chrX:49107447..49107461,-	p@chrX:49107447..49107461 -
Hg19::chrX:49113914..49113920,-	p@chrX:49113914..49113920 -
Hg19::chrX:49121165..49121179,-	p1@FOXP3
Hg19::chrY:23411611..23411629,+	p@chrY:23411611..23411629 +
Hg19::chrY:23411674..23411684,+	p@chrY:23411674..23411684 +
Hg19::chrY:23415362..23415365,+	p@chrY:23415362..23415365 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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p.value	FDR	nGenes	nPathway	Name
2.00529016035634e-05	0.0070700173582338	4	265	Cytokine-cytokine receptor interaction (KEGG):04060
2.23381275141668e-05	0.0070700173582338	3	88	Hematopoietic cell lineage (KEGG):04640
9.42667556910383e-05	0.0198902854508091	2	23	Cytokines and Inflammatory Response (Wikipathways):WP530

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0002440	production of molecular mediator of immune response	0.00683967092024917
GO:0006417	regulation of translation	0.00683967092024917
GO:0002573	myeloid leukocyte differentiation	0.00683967092024917
GO:0031326	regulation of cellular biosynthetic process	0.00683967092024917
GO:0042129	regulation of T cell proliferation	0.00683967092024917
GO:0009889	regulation of biosynthetic process	0.00683967092024917
GO:0042098	T cell proliferation	0.00683967092024917
GO:0017148	negative regulation of translation	0.00683967092024917
GO:0032944	regulation of mononuclear cell proliferation	0.00683967092024917
GO:0050670	regulation of lymphocyte proliferation	0.00683967092024917
GO:0031327	negative regulation of cellular biosynthetic process	0.00683967092024917
GO:0009890	negative regulation of biosynthetic process	0.00683967092024917
GO:0002376	immune system process	0.00683967092024917
GO:0032943	mononuclear cell proliferation	0.00683967092024917
GO:0046651	lymphocyte proliferation	0.00683967092024917
GO:0050863	regulation of T cell activation	0.00683967092024917
GO:0042089	cytokine biosynthetic process	0.00683967092024917
GO:0042107	cytokine metabolic process	0.00683967092024917
GO:0005157	macrophage colony stimulating factor receptor binding	0.00683967092024917
GO:0032693	negative regulation of interleukin-10 production	0.00683967092024917
GO:0050164	oxoglutarate dehydrogenase (NADP+) activity	0.00683967092024917
GO:0032689	negative regulation of interferon-gamma production	0.00683967092024917
GO:0032673	regulation of interleukin-4 production	0.00683967092024917
GO:0032601	connective tissue growth factor production	0.00683967092024917
GO:0005136	interleukin-4 receptor binding	0.00683967092024917
GO:0004276	furin activity	0.00683967092024917
GO:0002725	negative regulation of T cell cytokine production	0.00683967092024917
GO:0032713	negative regulation of interleukin-4 production	0.00683967092024917
GO:0045189	connective tissue growth factor biosynthetic process	0.00683967092024917
GO:0051525	NFAT protein binding	0.00683967092024917
GO:0032804	negative regulation of low-density lipoprotein receptor catabolic process	0.00683967092024917
GO:0046007	negative regulation of activated T cell proliferation	0.00683967092024917
GO:0006968	cellular defense response	0.00683967092024917
GO:0002449	lymphocyte mediated immunity	0.00683967092024917
GO:0002250	adaptive immune response	0.00699486912992422
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	0.00699486912992422
GO:0051249	regulation of lymphocyte activation	0.00699486912992422
GO:0030099	myeloid cell differentiation	0.00699486912992422
GO:0002443	leukocyte mediated immunity	0.00699486912992422
GO:0050865	regulation of cell activation	0.00717289543612794
GO:0002521	leukocyte differentiation	0.00774819298077369
GO:0051246	regulation of protein metabolic process	0.00774819298077369
GO:0042110	T cell activation	0.00774819298077369
GO:0050776	regulation of immune response	0.00774819298077369
GO:0019955	cytokine binding	0.00774819298077369
GO:0002682	regulation of immune system process	0.00774819298077369
GO:0032653	regulation of interleukin-10 production	0.00774819298077369
GO:0004910	interleukin-1, Type II, blocking receptor activity	0.00774819298077369
GO:0032803	regulation of low-density lipoprotein receptor catabolic process	0.00774819298077369
GO:0002704	negative regulation of leukocyte mediated immunity	0.00774819298077369
GO:0032703	negative regulation of interleukin-2 production	0.00774819298077369
GO:0032801	receptor catabolic process	0.00774819298077369
GO:0002710	negative regulation of T cell mediated immunity	0.00774819298077369
GO:0048295	positive regulation of isotype switching to IgE isotypes	0.00774819298077369
GO:0002707	negative regulation of lymphocyte mediated immunity	0.00774819298077369
GO:0032802	low-density lipoprotein receptor catabolic process	0.00774819298077369
GO:0032792	inhibition of CREB transcription factor	0.00774819298077369
GO:0019968	interleukin-1, Type II, blocking binding	0.00774819298077369
GO:0051248	negative regulation of protein metabolic process	0.00819216705586183
GO:0042127	regulation of cell proliferation	0.00885534337479167
GO:0002252	immune effector process	0.00885534337479167
GO:0001816	cytokine production	0.0090803420662768
GO:0042592	homeostatic process	0.0090803420662768
GO:0032799	low-density lipoprotein receptor metabolic process	0.00949230836421774
GO:0048289	isotype switching to IgE isotypes	0.00949230836421774
GO:0002701	negative regulation of production of molecular mediator of immune response	0.00949230836421774
GO:0016565	general transcriptional repressor activity	0.00949230836421774
GO:0048293	regulation of isotype switching to IgE isotypes	0.00949230836421774
GO:0045085	negative regulation of interleukin-2 biosynthetic process	0.00949230836421774
GO:0048304	positive regulation of isotype switching to IgG isotypes	0.00949230836421774
GO:0002719	negative regulation of cytokine production during immune response	0.00949230836421774
GO:0006955	immune response	0.0105740373439106
GO:0050710	negative regulation of cytokine secretion	0.0113544630907996
GO:0048302	regulation of isotype switching to IgG isotypes	0.0113544630907996
GO:0015379	potassium:chloride symporter activity	0.0113544630907996
GO:0032633	interleukin-4 production	0.0113544630907996
GO:0002698	negative regulation of immune effector process	0.0113544630907996
GO:0032088	inhibition of NF-kappaB transcription factor	0.0113544630907996
GO:0048291	isotype switching to IgG isotypes	0.0113544630907996
GO:0042330	taxis	0.0113544630907996
GO:0006935	chemotaxis	0.0113544630907996
GO:0046649	lymphocyte activation	0.01275901911404
GO:0002820	negative regulation of adaptive immune response	0.01275901911404
GO:0002369	T cell cytokine production	0.01275901911404
GO:0032613	interleukin-10 production	0.01275901911404
GO:0045348	positive regulation of MHC class II biosynthetic process	0.01275901911404
GO:0002823	negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	0.01275901911404
GO:0002724	regulation of T cell cytokine production	0.01275901911404
GO:0030097	hemopoiesis	0.0128714643838124
GO:0048534	hemopoietic or lymphoid organ development	0.0136068165663078
GO:0045342	MHC class II biosynthetic process	0.0136068165663078
GO:0045830	positive regulation of isotype switching	0.0136068165663078
GO:0045346	regulation of MHC class II biosynthetic process	0.0136068165663078
GO:0002709	regulation of T cell mediated immunity	0.0136068165663078
GO:0050709	negative regulation of protein secretion	0.0136068165663078
GO:0006884	regulation of cell volume	0.0136068165663078
GO:0043029	T cell homeostasis	0.0136068165663078
GO:0032663	regulation of interleukin-2 production	0.0136068165663078
GO:0032649	regulation of interferon-gamma production	0.0136068165663078
GO:0045321	leukocyte activation	0.0142592197625642
GO:0007626	locomotory behavior	0.0142721472839673
GO:0002520	immune system development	0.0142856100530098
GO:0046006	regulation of activated T cell proliferation	0.0148232410809889
GO:0045671	negative regulation of osteoclast differentiation	0.0148232410809889
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	0.0148232410809889
GO:0050798	activated T cell proliferation	0.0148232410809889
GO:0042130	negative regulation of T cell proliferation	0.0166237024164733
GO:0004908	interleukin-1 receptor activity	0.0166237024164733
GO:0001775	cell activation	0.0167419623278427
GO:0008283	cell proliferation	0.0167419623278427
GO:0002718	regulation of cytokine production during immune response	0.0167419623278427
GO:0002700	regulation of production of molecular mediator of immune response	0.0167419623278427
GO:0045670	regulation of osteoclast differentiation	0.0167419623278427
GO:0004945	angiotensin type II receptor activity	0.0167419623278427
GO:0001595	angiotensin receptor activity	0.0167419623278427
GO:0050777	negative regulation of immune response	0.0167419623278427
GO:0002762	negative regulation of myeloid leukocyte differentiation	0.0167419623278427
GO:0045191	regulation of isotype switching	0.0167419623278427
GO:0002367	cytokine production during immune response	0.0167419623278427
GO:0030890	positive regulation of B cell proliferation	0.0167419623278427
GO:0065007	biological regulation	0.0167419623278427
GO:0002683	negative regulation of immune system process	0.0174971254258332
GO:0042092	T-helper 2 type immune response	0.0174971254258332
GO:0002456	T cell mediated immunity	0.0174971254258332
GO:0019966	interleukin-1 binding	0.0174971254258332
GO:0002260	lymphocyte homeostasis	0.0174971254258332
GO:0001818	negative regulation of cytokine production	0.0174971254258332
GO:0030888	regulation of B cell proliferation	0.0174971254258332
GO:0008284	positive regulation of cell proliferation	0.0174971254258332
GO:0006873	cellular ion homeostasis	0.0174971254258332
GO:0055082	cellular chemical homeostasis	0.0174971254258332
GO:0043112	receptor metabolic process	0.0174971254258332
GO:0030316	osteoclast differentiation	0.0174971254258332
GO:0002208	somatic diversification of immunoglobulins during immune response	0.0174971254258332
GO:0002381	immunoglobulin production during immune response	0.0174971254258332
GO:0050868	negative regulation of T cell activation	0.0174971254258332
GO:0030225	macrophage differentiation	0.0174971254258332
GO:0050672	negative regulation of lymphocyte proliferation	0.0174971254258332
GO:0002204	somatic recombination of immunoglobulin genes during immune response	0.0174971254258332
GO:0045190	isotype switching	0.0174971254258332
GO:0032945	negative regulation of mononuclear cell proliferation	0.0174971254258332
GO:0002703	regulation of leukocyte mediated immunity	0.0186862618924103
GO:0002706	regulation of lymphocyte mediated immunity	0.0186862618924103
GO:0015377	cation:chloride symporter activity	0.0186862618924103
GO:0008083	growth factor activity	0.0191008012011806
GO:0016447	somatic recombination of immunoglobulin gene segments	0.0196922737065576
GO:0002819	regulation of adaptive immune response	0.0196922737065576
GO:0002822	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.	0.0196922737065576
GO:0050801	ion homeostasis	0.0206327863999324
GO:0001776	leukocyte homeostasis	0.0209199940569343
GO:0005515	protein binding	0.0210090596731958
GO:0051239	regulation of multicellular organismal process	0.0210090596731958
GO:0045941	positive regulation of transcription	0.0210090596731958
GO:0016444	somatic cell DNA recombination	0.0210090596731958
GO:0048872	homeostasis of number of cells	0.0210090596731958
GO:0016445	somatic diversification of immunoglobulins	0.0210090596731958
GO:0045076	regulation of interleukin-2 biosynthetic process	0.0210090596731958
GO:0002697	regulation of immune effector process	0.0210090596731958
GO:0002761	regulation of myeloid leukocyte differentiation	0.0210090596731958
GO:0002562	somatic diversification of immune receptors via germline recombination within a single locus	0.0210090596731958
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0214659153375232
GO:0042094	interleukin-2 biosynthetic process	0.0214659153375232
GO:0002200	somatic diversification of immune receptors	0.0214659153375232
GO:0043433	negative regulation of transcription factor activity	0.0214659153375232
GO:0006465	signal peptide processing	0.0214659153375232
GO:0050707	regulation of cytokine secretion	0.0214659153375232
GO:0042036	negative regulation of cytokine biosynthetic process	0.0214659153375232
GO:0007610	behavior	0.022043145403191
GO:0051048	negative regulation of secretion	0.0225329827501509
GO:0048878	chemical homeostasis	0.0226474620966088
GO:0065008	regulation of biological quality	0.0226474620966088
GO:0048522	positive regulation of cellular process	0.0226474620966088
GO:0051059	NF-kappaB binding	0.0226474620966088
GO:0002377	immunoglobulin production	0.0226474620966088
GO:0050871	positive regulation of B cell activation	0.0226474620966088
GO:0032609	interferon-gamma production	0.0226474620966088
GO:0042100	B cell proliferation	0.0226474620966088
GO:0045638	negative regulation of myeloid cell differentiation	0.0226474620966088
GO:0005125	cytokine activity	0.0229122396093299
GO:0051250	negative regulation of lymphocyte activation	0.0236351688993002
GO:0050663	cytokine secretion	0.0247365777129357
GO:0032623	interleukin-2 production	0.0256842556334335
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	0.0256842556334335
GO:0048518	positive regulation of biological process	0.0288621617302424
GO:0019957	C-C chemokine binding	0.0288621617302424
GO:0016493	C-C chemokine receptor activity	0.0288621617302424
GO:0051241	negative regulation of multicellular organismal process	0.0295234892360718
GO:0042102	positive regulation of T cell proliferation	0.0295234892360718
GO:0050864	regulation of B cell activation	0.0295234892360718
GO:0031325	positive regulation of cellular metabolic process	0.0295234892360718
GO:0050708	regulation of protein secretion	0.0304362923968099
GO:0019725	cellular homeostasis	0.0307627271557973
GO:0031324	negative regulation of cellular metabolic process	0.031543669199429
GO:0006518	peptide metabolic process	0.0322573951588899
GO:0009893	positive regulation of metabolic process	0.032689212371392
GO:0048523	negative regulation of cellular process	0.032689212371392
GO:0030183	B cell differentiation	0.032727770443523
GO:0030140	trans-Golgi network transport vesicle	0.032727770443523
GO:0032946	positive regulation of mononuclear cell proliferation	0.0335108540097155
GO:0050671	positive regulation of lymphocyte proliferation	0.0335108540097155
GO:0048519	negative regulation of biological process	0.0353893559769884
GO:0006412	translation	0.0372036479975713
GO:0045637	regulation of myeloid cell differentiation	0.0372036479975713
GO:0004907	interleukin receptor activity	0.0372036479975713
GO:0004289	subtilase activity	0.0381032136950474
GO:0009892	negative regulation of metabolic process	0.0381769303645508
GO:0004950	chemokine receptor activity	0.0386186634662823
GO:0001637	G-protein chemoattractant receptor activity	0.0386186634662823
GO:0006066	alcohol metabolic process	0.0391107838973536
GO:0019956	chemokine binding	0.0403593060030109
GO:0015296	anion:cation symporter activity	0.0410221858338763
GO:0051015	actin filament binding	0.0410221858338763
GO:0019965	interleukin binding	0.0418678931946746
GO:0050870	positive regulation of T cell activation	0.0425066411937473
GO:0001817	regulation of cytokine production	0.0425066411937473

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
leukocyte	1.05e-46	140
hematopoietic stem cell	2.05e-46	172
angioblastic mesenchymal cell	2.05e-46	172
hematopoietic cell	1.01e-44	182
hematopoietic oligopotent progenitor cell	1.77e-44	165
hematopoietic multipotent progenitor cell	1.77e-44	165
nongranular leukocyte	2.63e-39	119
hematopoietic lineage restricted progenitor cell	5.58e-39	124
lymphocyte	2.97e-26	53
common lymphoid progenitor	2.97e-26	53
lymphoid lineage restricted progenitor cell	7.21e-26	52
myeloid cell	5.66e-19	112
common myeloid progenitor	5.66e-19	112
myeloid leukocyte	6.88e-16	76
granulocyte monocyte progenitor cell	9.53e-15	71
T cell	5.21e-14	25
pro-T cell	5.21e-14	25
myeloid lineage restricted progenitor cell	1.54e-13	70
macrophage dendritic cell progenitor	1.84e-13	65
monopoietic cell	1.16e-12	63
monocyte	1.16e-12	63
monoblast	1.16e-12	63
promonocyte	1.16e-12	63
mature alpha-beta T cell	3.24e-12	18
alpha-beta T cell	3.24e-12	18
immature T cell	3.24e-12	18
mature T cell	3.24e-12	18
immature alpha-beta T cell	3.24e-12	18
lymphocyte of B lineage	2.61e-11	24
pro-B cell	2.61e-11	24
CD14-positive, CD16-negative classical monocyte	1.20e-09	42
classical monocyte	3.13e-09	45
CD8-positive, alpha-beta T cell	9.54e-08	11
B cell	2.27e-07	14

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	1.16e-21	102
blood island	1.16e-21	102
hemolymphoid system	1.21e-19	112
adult organism	8.80e-14	115
bone marrow	1.57e-11	80
immune system	2.28e-10	115
blood	1.24e-09	15
haemolymphatic fluid	1.24e-09	15
organism substance	1.24e-09	15
bone element	1.26e-09	86
skeletal element	7.81e-07	101
skeletal system	7.81e-07	101
lateral plate mesoderm	9.34e-07	216

Disease

Ontology term	p-value	n
hematologic cancer	1.37e-07	51
immune system cancer	1.37e-07	51

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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