Coexpression cluster:C444

Full id: C444_CD14_trachea_tonsil_tongue_throat_salivary_gall

Phase1 CAGE Peaks

Hg19::chr11:1263090..1263101,+	p@chr11:1263090..1263101 +
Hg19::chr11:1267107..1267120,+	p4@MUC5B
Hg19::chr11:1267285..1267314,+	p14@MUC5B
Hg19::chr11:1283125..1283153,+	p@chr11:1283125..1283153 +
Hg19::chr11:1283367..1283377,+	p@chr11:1283367..1283377 +
Hg19::chr12:10998477..10998481,-	p@chr12:10998477..10998481 -
Hg19::chr18:108531..108547,+	p@chr18:108531..108547 +
Hg19::chr20:31611261..31611291,+	p1@BPIFB6
Hg19::chr20:31611311..31611316,+	p11@BPIFB6
Hg19::chr20:31611317..31611336,+	p2@BPIFB6
Hg19::chr20:31611463..31611474,+	p3@BPIFB6
Hg19::chr20:31830997..31831004,+	p@chr20:31830997..31831004 +
Hg19::chr20:31894723..31894752,+	p@chr20:31894723..31894752 +
Hg19::chr20:31897591..31897596,+	p@chr20:31897591..31897596 +
Hg19::chr20:31897621..31897629,+	p@chr20:31897621..31897629 +
Hg19::chr20:31897630..31897644,+	p@chr20:31897630..31897644 +
Hg19::chr22:50643240..50643252,+	p@chr22:50643240..50643252 +
Hg19::chr9:138415783..138415790,+	p@chr9:138415783..138415790 +
Hg19::chr9:138418185..138418192,+	p@chr9:138418185..138418192 +
Hg19::chr9:138418232..138418239,+	p@chr9:138418232..138418239 +
Hg19::chr9:138418242..138418256,+	p@chr9:138418242..138418256 +
Hg19::chr9:138418258..138418269,+	p@chr9:138418258..138418269 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005201	extracellular matrix structural constituent	0.0217237725185447
GO:0030414	protease inhibitor activity	0.023489932885906
GO:0004857	enzyme inhibitor activity	0.0236076769103968
GO:0007155	cell adhesion	0.033910279053338
GO:0022610	biological adhesion	0.033910279053338

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CD14-positive, CD16-negative classical monocyte	7.73e-27	42
classical monocyte	2.95e-24	45
myeloid lineage restricted progenitor cell	1.92e-17	70
myeloid leukocyte	4.63e-17	76
granulocyte monocyte progenitor cell	5.04e-17	71
monopoietic cell	1.08e-14	63
monocyte	1.08e-14	63
monoblast	1.08e-14	63
promonocyte	1.08e-14	63
macrophage dendritic cell progenitor	6.42e-14	65
myeloid cell	2.31e-08	112
common myeloid progenitor	2.31e-08	112

Uber Anatomy

Ontology term	p-value	n
bone marrow	9.24e-14	80
bone element	1.02e-13	86
immune system	6.92e-13	115
skeletal element	5.08e-12	101
skeletal system	5.08e-12	101
hematopoietic system	6.01e-11	102
blood island	6.01e-11	102
hemolymphoid system	1.03e-09	112
organ	8.62e-09	511
embryo	2.41e-07	612
adult organism	5.35e-07	115
germ layer	5.81e-07	604
embryonic tissue	5.81e-07	604
presumptive structure	5.81e-07	604
epiblast (generic)	5.81e-07	604
multi-cellular organism	5.89e-07	659
embryonic structure	6.77e-07	605
developing anatomical structure	6.77e-07	605

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.