Coexpression cluster:C4003

Full id: C4003_CD14_CD4_immature_CD8_Natural_Neutrophils_CD19

Phase1 CAGE Peaks

Hg19::chr1:89357240..89357257,-	p1@GTF2B
Hg19::chr3:93781920..93781933,+	p2@NSUN3
Hg19::chr5:42992418..42992435,+	p@chr5:42992418..42992435 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

---

Cell Type

Ontology term	p-value	n
hematopoietic stem cell	2.22e-59	172
angioblastic mesenchymal cell	2.22e-59	172
leukocyte	1.27e-55	140
hematopoietic oligopotent progenitor cell	1.81e-55	165
hematopoietic multipotent progenitor cell	1.81e-55	165
hematopoietic cell	8.36e-54	182
hematopoietic lineage restricted progenitor cell	4.99e-49	124
nongranular leukocyte	6.60e-47	119
myeloid cell	7.97e-31	112
common myeloid progenitor	7.97e-31	112
myeloid leukocyte	1.35e-27	76
granulocyte monocyte progenitor cell	3.98e-25	71
myeloid lineage restricted progenitor cell	5.22e-25	70
CD14-positive, CD16-negative classical monocyte	5.75e-24	42
classical monocyte	4.32e-23	45
macrophage dendritic cell progenitor	6.87e-23	65
lymphocyte	4.29e-22	53
common lymphoid progenitor	4.29e-22	53
monopoietic cell	4.56e-22	63
monocyte	4.56e-22	63
monoblast	4.56e-22	63
promonocyte	4.56e-22	63
lymphoid lineage restricted progenitor cell	9.58e-22	52
mesenchymal cell	1.24e-16	358
connective tissue cell	1.78e-15	365
motile cell	4.98e-12	390
T cell	1.03e-11	25
pro-T cell	1.03e-11	25
mature alpha-beta T cell	3.68e-10	18
alpha-beta T cell	3.68e-10	18
immature T cell	3.68e-10	18
mature T cell	3.68e-10	18
immature alpha-beta T cell	3.68e-10	18
lymphocyte of B lineage	1.26e-09	24
pro-B cell	1.26e-09	24
B cell	6.25e-08	14
CD8-positive, alpha-beta T cell	8.51e-07	11
multi fate stem cell	9.85e-07	430

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	5.76e-32	102
blood island	5.76e-32	102
hemolymphoid system	3.90e-28	112
bone marrow	5.16e-23	80
bone element	6.30e-23	86
skeletal element	8.27e-17	101
skeletal system	8.27e-17	101
immune system	2.35e-15	115
connective tissue	7.12e-15	375
blood	3.43e-08	15
haemolymphatic fluid	3.43e-08	15
organism substance	3.43e-08	15

Disease

Ontology term	p-value	n
hematologic cancer	9.18e-07	51
immune system cancer	9.18e-07	51

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BRCA1#672	2	13.4561537621492	0.00711980771608456	0.0296272849653421
E2F6#1876	3	5.01715573169739	0.0079176980688633	0.0322686517058462
EGR1#1958	3	4.98817909481014	0.00805648813738344	0.032105142116155
ELF1#1997	3	4.25809795880754	0.0129517987505461	0.0462879550254349
ELK4#2005	2	10.823787772312	0.0109128471951648	0.0401991693078377
GABPB1#2553	3	7.06768383618217	0.00283221282541742	0.0154284099349974
MEF2A#4205	2	12.495487273096	0.00823502947802974	0.0324869020040775
MYC#4609	3	5.2222818716094	0.00702084375574015	0.0294880519989442
NFKB1#4790	3	5.48806342419384	0.00604938181565543	0.0269834879749397
PAX5#5079	3	6.66956553117783	0.00337029099967726	0.0173078537500759
POU2F2#5452	3	9.10612405774252	0.00132416519268213	0.00882993797462195
SIN3A#25942	3	5.40888472681514	0.00631896197799152	0.0277148525961472
SPI1#6688	3	8.20432350852273	0.00181059318941052	0.0109159234606503
STAT1#6772	2	13.8043916647995	0.00677093170844408	0.0287540900540069
TRIM28#10155	2	12.3936833635083	0.00836834412943847	0.032917083821115
ZEB1#6935	3	16.8884320175439	0.000207548691732758	0.00242979237931594

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.