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Coexpression cluster:C2304: Difference between revisions

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|tf_chipseq_enrich=CEBPB#1051;4:7.97114762582482:0.000247638578809083:0.00267734218760267!EGR1#1958;4:4.98817909481014:0.00161501150007605:0.0101333845633189!EP300#2033;4:6.7739417262232:0.000474845982144264:0.0043372782516324!ESR1#2099;4:30.7686032961545:1.11467714392546e-06:4.59596392555984e-05!FOS#2353;4:8.9979553088944:0.000152514771116863:0.00194629645413906!GATA2#2624;4:12.744931733554:3.78864877853583e-05:0.000720602239631222!NR3C1#2908;4:14.973023331173:1.98868032687801e-05:0.000442094049933615!TAF1#6872;4:3.34304628574529:0.00800566489870165:0.0321627802875635!TBP#6908;4:3.70677068709639:0.00529637781478435:0.0243752876480969
|tf_chipseq_enrich=CEBPB#1051;4:7.97114762582482:0.000247638578809083:0.00267734218760267!EGR1#1958;4:4.98817909481014:0.00161501150007605:0.0101333845633189!EP300#2033;4:6.7739417262232:0.000474845982144264:0.0043372782516324!ESR1#2099;4:30.7686032961545:1.11467714392546e-06:4.59596392555984e-05!FOS#2353;4:8.9979553088944:0.000152514771116863:0.00194629645413906!GATA2#2624;4:12.744931733554:3.78864877853583e-05:0.000720602239631222!NR3C1#2908;4:14.973023331173:1.98868032687801e-05:0.000442094049933615!TAF1#6872;4:3.34304628574529:0.00800566489870165:0.0321627802875635!TBP#6908;4:3.70677068709639:0.00529637781478435:0.0243752876480969
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}}
}}

Revision as of 15:24, 26 November 2012


Full id: C2304_malignant_mesothelioma_Keratinocyte_Mesenchymal_oral_epidermoid_Mammary



Phase1 CAGE Peaks

Hg19::chr14:59830347..59830363,+p@chr14:59830347..59830363
+
Hg19::chr14:59830369..59830387,+p@chr14:59830369..59830387
+
Hg19::chr14:59830398..59830424,+p@chr14:59830398..59830424
+
Hg19::chr14:59830427..59830451,+p@chr14:59830427..59830451
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
epithelial cell1.01e-21253
squamous epithelial cell5.72e-1863
embryonic cell3.40e-16250
mesodermal cell1.29e-10121
endo-epithelial cell2.87e-0942
cardiocyte7.56e-0816
endodermal cell2.66e-0758
vascular associated smooth muscle cell9.15e-0732
Uber Anatomy
Ontology termp-valuen
splanchnic layer of lateral plate mesoderm1.55e-1783
epithelial tube3.73e-12117
epithelial tube open at both ends4.61e-1259
blood vessel4.61e-1259
blood vasculature4.61e-1259
vascular cord4.61e-1259
vasculature1.58e-1178
vascular system1.58e-1178
vessel4.46e-1168
primordium1.82e-10160
circulatory system2.23e-10112
unilaminar epithelium2.24e-10148
artery2.63e-1042
arterial blood vessel2.63e-1042
arterial system2.63e-1042
cardiovascular system4.77e-10109
epithelium4.99e-10306
cell layer7.45e-10309
organism subdivision2.25e-09264
primary circulatory organ3.09e-0927
heart4.12e-0924
primitive heart tube4.12e-0924
primary heart field4.12e-0924
anterior lateral plate mesoderm4.12e-0924
heart tube4.12e-0924
heart primordium4.12e-0924
cardiac mesoderm4.12e-0924
cardiogenic plate4.12e-0924
heart rudiment4.12e-0924
multilaminar epithelium7.94e-0983
systemic artery9.85e-0933
systemic arterial system9.85e-0933
trunk2.13e-08199
anatomical cluster1.10e-07373
anatomical conduit1.14e-07240
aorta6.24e-0721
aortic system6.24e-0721
embryonic structure7.68e-07564
Disease
Ontology termp-valuen
squamous cell carcinoma9.67e-0814
carcinoma6.51e-07106


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105147.971147625824820.0002476385788090830.00267734218760267
EGR1#195844.988179094810140.001615011500076050.0101333845633189
EP300#203346.77394172622320.0004748459821442640.0043372782516324
ESR1#2099430.76860329615451.11467714392546e-064.59596392555984e-05
FOS#235348.99795530889440.0001525147711168630.00194629645413906
GATA2#2624412.7449317335543.78864877853583e-050.000720602239631222
NR3C1#2908414.9730233311731.98868032687801e-050.000442094049933615
TAF1#687243.343046285745290.008005664898701650.0321627802875635
TBP#690843.706770687096390.005296377814784350.0243752876480969



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.