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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0

Latest revision as of 11:51, 17 September 2013


Full id: C1771_CD14_Neutrophils_Eosinophils_Peripheral_Whole_CD14CD16_blood



Phase1 CAGE Peaks

Hg19::chr16:8727024..8727043,+p@chr16:8727024..8727043
+
Hg19::chr1:150583889..150583898,-p@chr1:150583889..150583898
-
Hg19::chr20:46369846..46369868,+p@chr20:46369846..46369868
+
Hg19::chr22:30666830..30666847,-p@chr22:30666830..30666847
-
Hg19::chr2:219235586..219235598,+p@chr2:219235586..219235598
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
classical monocyte2.25e-13342
CD14-positive, CD16-negative classical monocyte2.25e-13342
defensive cell1.84e-11548
phagocyte1.84e-11548
myeloid leukocyte4.04e-9872
monopoietic cell2.21e-9059
monocyte2.21e-9059
monoblast2.21e-9059
promonocyte2.21e-9059
macrophage dendritic cell progenitor3.81e-8761
myeloid lineage restricted progenitor cell6.71e-8066
granulocyte monocyte progenitor cell1.41e-7867
leukocyte3.51e-62136
myeloid cell3.58e-62108
common myeloid progenitor3.58e-62108
stuff accumulating cell3.05e-5987
nongranular leukocyte4.07e-57115
hematopoietic stem cell2.81e-48168
angioblastic mesenchymal cell2.81e-48168
hematopoietic lineage restricted progenitor cell1.84e-46120
hematopoietic cell2.89e-45177
hematopoietic oligopotent progenitor cell4.35e-44161
hematopoietic multipotent progenitor cell4.35e-44161
intermediate monocyte1.17e-299
CD14-positive, CD16-positive monocyte1.17e-299
mesenchymal cell5.27e-17354
connective tissue cell1.88e-16361
granulocyte5.09e-168
motile cell1.65e-14386
multi fate stem cell3.93e-12427
somatic stem cell8.35e-12433
single nucleate cell1.08e-113
mononuclear cell1.08e-113
blood cell1.86e-1111
stem cell2.22e-11441
basophil6.07e-113
non-classical monocyte2.22e-103
CD14-low, CD16-positive monocyte2.22e-103
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.08e-7598
blood island1.08e-7598
bone marrow3.14e-6876
hemolymphoid system9.55e-68108
bone element1.41e-6282
skeletal element3.37e-5690
immune system4.35e-5493
skeletal system1.20e-49100
lateral plate mesoderm4.37e-31203
musculoskeletal system6.91e-26167
mesoderm3.71e-16315
mesoderm-derived structure3.71e-16315
presumptive mesoderm3.71e-16315
connective tissue1.06e-15371
blood1.22e-1315
haemolymphatic fluid1.22e-1315
organism substance1.22e-1315


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0497246
MA0004.10.626788
MA0006.11.14863
MA0007.10.606704
MA0009.12.51467
MA0014.10.369468
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.288856
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.10.522232
MA0060.10.860776
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.00220137
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.11.2972
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.132006
MA0089.10
MA0090.10.556637
MA0091.11.52322
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.10.175503
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.442008
MA0146.10.143081
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.527987
MA0138.20.837782
MA0002.21.50443
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.20.425004
MA0065.20.880827
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.172764
MA0155.10.813062
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.21472
MA0163.10.168633
MA0164.10.810347
MA0080.21.15604
MA0018.20.781393
MA0099.20.699641
MA0079.20.0442129
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
MAFF#23764222.52614259597810.003041818451272880.0160479125698367



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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