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{{Coexpression_clusters
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|full_id=C4811_Fibroblast_extraskeletal_leiomyoma_Smooth_giant_mesenchymal_Synoviocyte
|id=C4811
|ontology_enrichment_celltype=CL:0000055!1.89e-44!180;CL:0000057!1.35e-24!75;CL:0000222!9.28e-22!119;CL:0000680!1.22e-19!57;CL:0000056!1.22e-19!57;CL:0000355!1.22e-19!57;CL:0000183!1.19e-18!59;CL:0000187!6.17e-18!54;CL:0000393!4.75e-17!60;CL:0000211!4.75e-17!60;CL:0000192!3.03e-13!42;CL:0000514!3.03e-13!42;CL:0002620!4.66e-13!23;CL:0000220!4.78e-12!246;CL:0002321!1.05e-11!248;CL:0000359!1.95e-11!32;CL:0002139!6.10e-08!24;CL:0002371!2.74e-07!591
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000914!2.40e-26!83;UBERON:0002329!2.40e-26!83;UBERON:0003077!2.40e-26!83;UBERON:0003059!2.40e-26!83;UBERON:0007282!2.40e-26!83;UBERON:0009618!2.40e-26!83;UBERON:0007285!2.40e-26!83;UBERON:0004290!2.50e-23!70;UBERON:0002049!3.20e-23!79;UBERON:0007798!3.20e-23!79;UBERON:0000055!3.72e-20!69;UBERON:0004872!5.19e-20!84;UBERON:0000486!9.12e-20!82;UBERON:0001134!2.35e-19!61;UBERON:0002036!2.35e-19!61;UBERON:0003082!2.35e-19!61;UBERON:0002385!2.77e-19!63;UBERON:0001015!2.77e-19!63;UBERON:0000383!2.77e-19!63;UBERON:0001981!1.95e-18!60;UBERON:0007500!1.95e-18!60;UBERON:0004537!1.95e-18!60;UBERON:0006965!1.95e-18!60;UBERON:0004535!9.38e-17!110;UBERON:0005256!2.03e-16!143;UBERON:0001009!2.20e-16!113;UBERON:0001637!4.28e-15!42;UBERON:0003509!4.28e-15!42;UBERON:0004572!4.28e-15!42;UBERON:0000475!9.20e-15!365;UBERON:0003914!1.22e-13!118;UBERON:0000490!3.35e-13!138;UBERON:0000468!9.99e-13!659;UBERON:0000119!1.19e-12!312;UBERON:0004573!1.58e-12!33;UBERON:0004571!1.58e-12!33;UBERON:0000483!3.00e-12!309;UBERON:0002199!9.60e-12!45;UBERON:0002416!9.60e-12!45;UBERON:0003102!4.69e-11!95;UBERON:0002097!2.62e-10!40;UBERON:0000467!5.85e-10!625;UBERON:0002100!7.34e-10!216;UBERON:0000481!8.97e-10!347;UBERON:0000480!9.09e-10!626;UBERON:0000477!2.19e-09!286;UBERON:0000947!8.83e-09!21;UBERON:0010191!8.83e-09!21;UBERON:0004111!1.93e-07!241;UBERON:0003104!2.70e-07!238;UBERON:0009142!2.70e-07!238
}}

Latest revision as of 14:20, 17 September 2013


Full id: C4811_Fibroblast_extraskeletal_leiomyoma_Smooth_giant_mesenchymal_Synoviocyte



Phase1 CAGE Peaks

Hg19::chr9:18474125..18474160,+p1@ADAMTSL1
Hg19::chr9:18474163..18474202,+p2@ADAMTSL1
Hg19::chr9:18474204..18474215,+p3@ADAMTSL1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
dense mesenchyme tissue2.93e-2373
somite3.65e-2371
presomitic mesoderm3.65e-2371
presumptive segmental plate3.65e-2371
dermomyotome3.65e-2371
trunk paraxial mesoderm3.65e-2371
paraxial mesoderm5.40e-2372
presumptive paraxial mesoderm5.40e-2372
vasculature5.64e-2378
vascular system5.64e-2378
epithelial vesicle1.47e-2278
vessel5.04e-2068
splanchnic layer of lateral plate mesoderm9.82e-2083
multilaminar epithelium1.78e-1983
skeletal muscle tissue3.46e-1962
striated muscle tissue3.46e-1962
myotome3.46e-1962
muscle tissue3.93e-1964
musculature3.93e-1964
musculature of body3.93e-1964
epithelial tube open at both ends3.20e-1859
blood vessel3.20e-1859
blood vasculature3.20e-1859
vascular cord3.20e-1859
cardiovascular system9.28e-17109
unilaminar epithelium1.74e-16148
circulatory system2.18e-16112
artery6.83e-1542
arterial blood vessel6.83e-1542
arterial system6.83e-1542
mesenchyme2.26e-14160
entire embryonic mesenchyme2.26e-14160
trunk mesenchyme3.33e-13122
epithelial tube6.66e-13117
integument9.30e-1346
integumental system9.30e-1346
cell layer2.20e-12309
systemic artery3.70e-1233
systemic arterial system3.70e-1233
multi-cellular organism4.11e-12656
epithelium5.72e-12306
surface structure7.54e-1299
skin of body2.40e-1141
organism subdivision4.46e-11264
anatomical system6.58e-11624
anatomical group1.02e-10625
anatomical cluster8.87e-10373
multi-tissue structure1.61e-09342
aorta9.71e-0921
aortic system9.71e-0921
mesoderm1.72e-08315
mesoderm-derived structure1.72e-08315
presumptive mesoderm1.72e-08315
trunk1.83e-07199
blood vessel endothelium6.00e-0718
endothelium6.00e-0718
cardiovascular system endothelium6.00e-0718
anatomical conduit6.58e-07240
adipose tissue8.28e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.401049
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.15.06231
MA0052.11.24796
MA0055.10.557638
MA0056.10
MA0057.10.886807
MA0058.10.716037
MA0059.10.714521
MA0060.12.13518
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.12.75836
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.112.1974
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.715722
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.12.7939
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.12.07172
MA0141.10.712476
MA0142.11.12317
MA0143.13.75836
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.757898
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.12.7096
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.8915
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.181755
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EP300#203336.77394172622320.003216880500103790.0168633128821131
GATA2#2624312.7449317335540.0004829527704283790.00439326751944687
REST#597839.650028716128020.001112636247114590.0077205911243373



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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