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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0,0

Latest revision as of 12:12, 17 September 2013


Full id: C2759_CD14_CD8_immature_Natural_CD34_CD19_Peripheral



Phase1 CAGE Peaks

Hg19::chr3:9440425..9440445,-p2@ENST00000519043
Hg19::chr3:9440451..9440496,-p1@ENST00000519043
Hg19::chr4:139937032..139937054,+p2@CCRN4L
Hg19::chr9:131710317..131710335,-p3@DOLK


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0004605phosphatidate cytidylyltransferase activity0.00671121183306963



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte3.20e-36136
nongranular leukocyte2.03e-26115
hematopoietic stem cell2.17e-26168
angioblastic mesenchymal cell2.17e-26168
hematopoietic lineage restricted progenitor cell3.60e-26120
hematopoietic cell6.33e-26177
classical monocyte9.41e-2642
CD14-positive, CD16-negative classical monocyte9.41e-2642
hematopoietic oligopotent progenitor cell4.47e-23161
hematopoietic multipotent progenitor cell4.47e-23161
myeloid leukocyte5.63e-2172
defensive cell1.26e-1948
phagocyte1.26e-1948
granulocyte monocyte progenitor cell5.10e-1967
macrophage dendritic cell progenitor1.80e-1761
myeloid lineage restricted progenitor cell1.58e-1666
monopoietic cell3.67e-1659
monocyte3.67e-1659
monoblast3.67e-1659
promonocyte3.67e-1659
myeloid cell8.20e-14108
common myeloid progenitor8.20e-14108
lymphocyte3.34e-0953
common lymphoid progenitor3.34e-0953
stem cell5.14e-09441
lymphoid lineage restricted progenitor cell7.68e-0952
lymphocyte of B lineage1.37e-0824
pro-B cell1.37e-0824
nucleate cell2.53e-0855
multi fate stem cell3.74e-08427
dendritic cell9.44e-0810
mesenchymal cell9.91e-08354
animal cell1.06e-07679
eukaryotic cell1.06e-07679
native cell2.17e-07722
somatic stem cell2.65e-07433
stuff accumulating cell7.15e-0787
connective tissue cell9.90e-07361
Uber Anatomy
Ontology termp-valuen
bone marrow1.04e-1576
immune system1.42e-1593
hematopoietic system1.14e-1498
blood island1.14e-1498
hemolymphoid system1.41e-14108
bone element5.20e-1482
skeletal element5.35e-1290
skeletal system6.18e-09100
lateral plate mesoderm6.55e-07203


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.233555
MA0004.10.71247
MA0006.11.31813
MA0007.10.6918
MA0009.11.20602
MA0014.10.896009
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.11.91805
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.13.49299
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.11.8408
MA0072.11.1744
MA0073.10.00636811
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.12.29123
MA0103.10.521546
MA0105.13.51257
MA0106.10.869173
MA0107.12.98058
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.11.08195
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.257871
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.21.7213
MA0150.11.53138
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.640035
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.0270533
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL3#602217.27355140186920.004834494208076070.0226783031170166
FOXA1#316938.311064812039090.002740138182109850.0150397988018378
NFKB1#479045.488063424193840.001102199566301980.00768904017801164
POU2F2#545249.106124057742520.000145395665174930.00188562993607407
TBP#690843.706770687096390.005296377814784350.0244777592087027



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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