Coexpression cluster:C1325

Full id: C1325_CD19_cord_Eosinophils_b_B_Neutrophils_acute

Phase1 CAGE Peaks

Hg19::chr11:102188224..102188235,+	p3@BIRC3
Hg19::chr11:102188241..102188255,+	p2@BIRC3
Hg19::chr17:38020392..38020477,-	p1@IKZF3
Hg19::chr2:231090344..231090361,-	p3@SP110
Hg19::chr2:231090433..231090469,+	p1@SP140
Hg19::chr2:231090471..231090504,+	p2@SP140

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008270	zinc ion binding	0.0136564976516669
GO:0046914	transition metal ion binding	0.0136564976516669
GO:0005062	hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity	0.0136564976516669
GO:0005634	nucleus	0.021856297443892
GO:0043169	cation binding	0.021856297443892
GO:0046872	metal ion binding	0.021856297443892
GO:0043167	ion binding	0.021856297443892
GO:0003677	DNA binding	0.0396340780388288
GO:0043231	intracellular membrane-bound organelle	0.0396340780388288
GO:0043227	membrane-bound organelle	0.0396340780388288
GO:0007498	mesoderm development	0.0408971864373122

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
leukocyte	1.60e-59	140
hematopoietic stem cell	2.37e-49	172
angioblastic mesenchymal cell	2.37e-49	172
nongranular leukocyte	4.86e-49	119
hematopoietic lineage restricted progenitor cell	1.51e-48	124
hematopoietic oligopotent progenitor cell	3.22e-46	165
hematopoietic multipotent progenitor cell	3.22e-46	165
hematopoietic cell	3.25e-46	182
lymphocyte	1.82e-30	53
common lymphoid progenitor	1.82e-30	53
lymphoid lineage restricted progenitor cell	8.18e-30	52
myeloid leukocyte	9.03e-23	76
granulocyte monocyte progenitor cell	1.85e-18	71
myeloid lineage restricted progenitor cell	2.24e-18	70
classical monocyte	4.85e-18	45
myeloid cell	7.36e-18	112
common myeloid progenitor	7.36e-18	112
CD14-positive, CD16-negative classical monocyte	7.56e-18	42
macrophage dendritic cell progenitor	8.09e-18	65
monopoietic cell	3.65e-17	63
monocyte	3.65e-17	63
monoblast	3.65e-17	63
promonocyte	3.65e-17	63
lymphocyte of B lineage	9.87e-16	24
pro-B cell	9.87e-16	24
T cell	2.55e-13	25
pro-T cell	2.55e-13	25
mature alpha-beta T cell	9.46e-12	18
alpha-beta T cell	9.46e-12	18
immature T cell	9.46e-12	18
mature T cell	9.46e-12	18
immature alpha-beta T cell	9.46e-12	18
B cell	4.68e-10	14
CD8-positive, alpha-beta T cell	8.79e-08	11

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	7.41e-25	102
blood island	7.41e-25	102
hemolymphoid system	1.93e-22	112
bone marrow	2.09e-14	80
bone element	3.31e-13	86
immune system	2.62e-12	115
adult organism	5.24e-10	115
blood	1.18e-09	15
haemolymphatic fluid	1.18e-09	15
organism substance	1.18e-09	15
skeletal element	9.91e-09	101
skeletal system	9.91e-09	101

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.