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Coexpression cluster:C1963: Difference between revisions

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|tf_chipseq_enrich=BCL11A#53335;4:22.6955640828856:7.49488101632307e-06:0.00021451298395828!BCL3#602;4:27.6376822429907:3.425174836939e-06:0.000114215145209155!EBF1#1879;4:7.1251734772552:0.000723053104677421:0.00577419660493999!EP300#2033;4:5.41915338097856:0.0020938692794389:0.0121267461695403!IRF4#3662;4:17.5316101493953:2.08739444052064e-05:0.0004610943062046!MEF2A#4205;4:14.9945847277152:3.876195075647e-05:0.000728366206379087!NFKB1#4790;4:4.39045073935507:0.00470773269252496:0.0222093637489662!PAX5#5079;4:5.33565242494226:0.00222338958618779:0.0127825930304892!POU2F2#5452;4:7.28489924619402:0.000663122328874386:0.00542714778663992!RFX5#5993;4:9.63832866175608:0.00022148012581572:0.00249850538561978!SP1#6667;4:4.55870510251272:0.0040757356578168:0.0194928679015766!SPI1#6688;4:6.56345880681818:0.000995742963645402:0.00714443524183582!YY1#7528;4:3.92893659988308:0.00719386626991762:0.0298557599588288
|tf_chipseq_enrich=BCL11A#53335;4:22.6955640828856:7.49488101632307e-06:0.00021451298395828!BCL3#602;4:27.6376822429907:3.425174836939e-06:0.000114215145209155!EBF1#1879;4:7.1251734772552:0.000723053104677421:0.00577419660493999!EP300#2033;4:5.41915338097856:0.0020938692794389:0.0121267461695403!IRF4#3662;4:17.5316101493953:2.08739444052064e-05:0.0004610943062046!MEF2A#4205;4:14.9945847277152:3.876195075647e-05:0.000728366206379087!NFKB1#4790;4:4.39045073935507:0.00470773269252496:0.0222093637489662!PAX5#5079;4:5.33565242494226:0.00222338958618779:0.0127825930304892!POU2F2#5452;4:7.28489924619402:0.000663122328874386:0.00542714778663992!RFX5#5993;4:9.63832866175608:0.00022148012581572:0.00249850538561978!SP1#6667;4:4.55870510251272:0.0040757356578168:0.0194928679015766!SPI1#6688;4:6.56345880681818:0.000995742963645402:0.00714443524183582!YY1#7528;4:3.92893659988308:0.00719386626991762:0.0298557599588288
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}}
}}

Revision as of 15:13, 26 November 2012


Full id: C1963_acute_CD14_Neutrophils_Dendritic_CD19_Eosinophils_CD34



Phase1 CAGE Peaks

Hg19::chr5:57787278..57787351,+p1@GAPT
Hg19::chrX:30595876..30595890,-p1@CXorf21
Hg19::chrX:30595907..30595941,-p2@CXorf21
Hg19::chrX:30595959..30595986,-p3@CXorf21
Hg19::chrX:30595997..30596014,-p5@CXorf21


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0016491oxidoreductase activity0.0458024255269045



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell4.45e-86168
angioblastic mesenchymal cell4.45e-86168
hematopoietic oligopotent progenitor cell2.64e-81161
hematopoietic multipotent progenitor cell2.64e-81161
hematopoietic cell5.91e-80177
leukocyte5.58e-76136
myeloid cell1.36e-65108
common myeloid progenitor1.36e-65108
hematopoietic lineage restricted progenitor cell9.95e-63120
nongranular leukocyte6.23e-60115
myeloid leukocyte1.37e-5672
granulocyte monocyte progenitor cell1.57e-5167
myeloid lineage restricted progenitor cell2.88e-4966
macrophage dendritic cell progenitor1.17e-4761
monopoietic cell8.36e-4659
monocyte8.36e-4659
monoblast8.36e-4659
promonocyte8.36e-4659
defensive cell6.99e-4048
phagocyte6.99e-4048
classical monocyte6.00e-3842
CD14-positive, CD16-negative classical monocyte6.00e-3842
lymphocyte of B lineage7.14e-1724
pro-B cell7.14e-1724
mesenchymal cell3.73e-15354
nucleate cell1.53e-1455
connective tissue cell4.69e-14361
lymphocyte5.09e-1453
common lymphoid progenitor5.09e-1453
lymphoid lineage restricted progenitor cell1.84e-1352
stuff accumulating cell2.48e-1387
B cell9.70e-1214
motile cell2.46e-10386
intermediate monocyte2.90e-099
CD14-positive, CD16-positive monocyte2.90e-099
dendritic cell5.76e-0910
granulocyte1.28e-088
conventional dendritic cell2.13e-078
Uber Anatomy
Ontology termp-valuen
hematopoietic system5.48e-5698
blood island5.48e-5698
hemolymphoid system2.47e-50108
bone marrow2.34e-4576
immune system5.54e-4293
bone element5.79e-4082
skeletal element6.04e-3490
skeletal system1.14e-28100
adult organism8.45e-18114
lateral plate mesoderm4.50e-15203
connective tissue5.08e-13371
musculoskeletal system4.82e-09167
blood1.18e-0815
haemolymphatic fluid1.18e-0815
organism substance1.18e-0815
Disease
Ontology termp-valuen
hematologic cancer1.92e-1051
immune system cancer1.92e-1051
myeloid leukemia2.29e-0931
leukemia5.47e-0939


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#53335422.69556408288567.49488101632307e-060.00021451298395828
BCL3#602427.63768224299073.425174836939e-060.000114215145209155
EBF1#187947.12517347725520.0007230531046774210.00577419660493999
EP300#203345.419153380978560.00209386927943890.0121267461695403
IRF4#3662417.53161014939532.08739444052064e-050.0004610943062046
MEF2A#4205414.99458472771523.876195075647e-050.000728366206379087
NFKB1#479044.390450739355070.004707732692524960.0222093637489662
PAX5#507945.335652424942260.002223389586187790.0127825930304892
POU2F2#545247.284899246194020.0006631223288743860.00542714778663992
RFX5#599349.638328661756080.000221480125815720.00249850538561978
SP1#666744.558705102512720.00407573565781680.0194928679015766
SPI1#668846.563458806818180.0009957429636454020.00714443524183582
YY1#752843.928936599883080.007193866269917620.0298557599588288



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.