Coexpression cluster:C103

Full id: C103_CD4_CD8_Natural_Peripheral_Whole_Neutrophils_Basophils

Phase1 CAGE Peaks

Hg19::chr10:116561109..116561139,-	p@chr10:116561109..116561139 -
Hg19::chr10:116561206..116561217,-	p@chr10:116561206..116561217 -
Hg19::chr10:120850774..120850786,+	p@chr10:120850774..120850786 +
Hg19::chr10:127684545..127684563,+	p@chr10:127684545..127684563 +
Hg19::chr10:127684574..127684597,+	p@chr10:127684574..127684597 +
Hg19::chr10:127684603..127684610,+	p@chr10:127684603..127684610 +
Hg19::chr10:127684797..127684804,+	p@chr10:127684797..127684804 +
Hg19::chr10:17697543..17697546,-	p@chr10:17697543..17697546 -
Hg19::chr10:17755334..17755338,+	p@chr10:17755334..17755338 +
Hg19::chr10:33403410..33403417,-	p@chr10:33403410..33403417 -
Hg19::chr10:33403568..33403605,+	p@chr10:33403568..33403605 +
Hg19::chr10:33405656..33405667,-	p3@ENST00000414308
Hg19::chr10:33405703..33405713,-	p2@ENST00000414308
Hg19::chr10:33405727..33405751,-	p1@ENST00000414308
Hg19::chr10:33423233..33423255,+	p@chr10:33423233..33423255 +
Hg19::chr10:33428350..33428361,+	p@chr10:33428350..33428361 +
Hg19::chr10:6337053..6337076,+	p@chr10:6337053..6337076 +
Hg19::chr10:6342353..6342370,+	p@chr10:6342353..6342370 +
Hg19::chr10:63807238..63807249,+	p@chr10:63807238..63807249 +
Hg19::chr10:63810303..63810331,+	p@chr10:63810303..63810331 +
Hg19::chr10:63810855..63810875,-	p@chr10:63810855..63810875 -
Hg19::chr10:63810885..63810913,-	p@chr10:63810885..63810913 -
Hg19::chr10:63978845..63978868,+	p@chr10:63978845..63978868 +
Hg19::chr10:63978876..63978886,+	p@chr10:63978876..63978886 +
Hg19::chr10:63995871..63995888,-	p4@RTKN2
Hg19::chr10:63996620..63996627,-	p@chr10:63996620..63996627 -
Hg19::chr10:63999878..63999893,-	p@chr10:63999878..63999893 -
Hg19::chr10:63999898..63999909,-	p@chr10:63999898..63999909 -
Hg19::chr11:111410267..111410269,+	p@chr11:111410267..111410269 +
Hg19::chr11:117150937..117150942,+	p@chr11:117150937..117150942 +
Hg19::chr11:117150945..117150958,+	p@chr11:117150945..117150958 +
Hg19::chr11:121322289..121322304,+	p@chr11:121322289..121322304 +
Hg19::chr11:121322360..121322393,+	p@chr11:121322360..121322393 +
Hg19::chr11:121322394..121322417,+	p12@SORL1
Hg19::chr12:12619140..12619146,-	p1@CU680647
Hg19::chr12:12619407..12619418,+	p@chr12:12619407..12619418 +
Hg19::chr12:12628211..12628227,+	p@chr12:12628211..12628227 +
Hg19::chr12:12628251..12628264,+	p@chr12:12628251..12628264 +
Hg19::chr12:12635181..12635187,-	p@chr12:12635181..12635187 -
Hg19::chr12:12635397..12635432,+	p@chr12:12635397..12635432 +
Hg19::chr12:12635434..12635452,+	p@chr12:12635434..12635452 +
Hg19::chr12:12635461..12635484,+	p@chr12:12635461..12635484 +
Hg19::chr12:12713961..12713976,-	p14@DUSP16
Hg19::chr12:12714006..12714021,-	p15@DUSP16
Hg19::chr12:12714025..12714064,-	p4@DUSP16
Hg19::chr12:12714066..12714108,+	p@chr12:12714066..12714108 +
Hg19::chr12:12775594..12775630,-	p@chr12:12775594..12775630 -
Hg19::chr12:56418637..56418648,+	p9@IKZF4
Hg19::chr12:92445353..92445356,-	p@chr12:92445353..92445356 -
Hg19::chr13:30510003..30510027,+	p1@ENST00000400540
Hg19::chr13:40765017..40765053,-	p@chr13:40765017..40765053 -
Hg19::chr13:48984656..48984665,+	p@chr13:48984656..48984665 +
Hg19::chr13:75900881..75900923,-	p2@TBC1D4
Hg19::chr13:87409604..87409610,-	p@chr13:87409604..87409610 -
Hg19::chr13:99967027..99967041,+	p16@UBAC2
Hg19::chr14:22976236..22976240,-	p@chr14:22976236..22976240 -
Hg19::chr14:23004404..23004417,+	p@chr14:23004404..23004417 +
Hg19::chr14:91712613..91712627,+	p@chr14:91712613..91712627 +
Hg19::chr14:91777214..91777217,+	p@chr14:91777214..91777217 +
Hg19::chr14:99707456..99707462,-	p@chr14:99707456..99707462 -
Hg19::chr15:22550911..22550920,+	p@chr15:22550911..22550920 +
Hg19::chr15:22550947..22550971,+	p@chr15:22550947..22550971 +
Hg19::chr15:38964056..38964101,+	p1@ENST00000557946
Hg19::chr15:62149711..62149734,-	p@chr15:62149711..62149734 -
Hg19::chr15:63961074..63961079,+	p@chr15:63961074..63961079 +
Hg19::chr15:63965111..63965141,-	p@chr15:63965111..63965141 -
Hg19::chr16:50372905..50372915,-	p@chr16:50372905..50372915 -
Hg19::chr16:57162957..57162973,+	p@chr16:57162957..57162973 +
Hg19::chr16:57164428..57164453,+	p@chr16:57164428..57164453 +
Hg19::chr17:29645688..29645699,+	p@chr17:29645688..29645699 +
Hg19::chr17:29645703..29645717,+	p@chr17:29645703..29645717 +
Hg19::chr17:29645772..29645777,+	p@chr17:29645772..29645777 +
Hg19::chr18:13276704..13276707,-	p@chr18:13276704..13276707 -
Hg19::chr18:13377159..13377168,+	p@chr18:13377159..13377168 +
Hg19::chr18:13383177..13383191,-	p@chr18:13383177..13383191 -
Hg19::chr18:21572756..21572768,+	p18@TTC39C
Hg19::chr18:21572789..21572809,+	p11@TTC39C
Hg19::chr18:21572813..21572830,+	p16@TTC39C
Hg19::chr18:21572835..21572856,+	p10@TTC39C
Hg19::chr18:21572860..21572883,+	p12@TTC39C
Hg19::chr18:2606630..2606643,+	p@chr18:2606630..2606643 +
Hg19::chr1:100889590..100889601,-	p@chr1:100889590..100889601 -
Hg19::chr1:100889615..100889640,-	p@chr1:100889615..100889640 -
Hg19::chr1:108329149..108329182,-	p@chr1:108329149..108329182 -
Hg19::chr1:118197380..118197387,+	p@chr1:118197380..118197387 +
Hg19::chr1:118198855..118198873,-	p@chr1:118198855..118198873 -
Hg19::chr1:118198878..118198907,-	p@chr1:118198878..118198907 -
Hg19::chr1:118198995..118199007,+	p@chr1:118198995..118199007 +
Hg19::chr1:118201616..118201641,+	p@chr1:118201616..118201641 +
Hg19::chr1:118207256..118207267,+	p@chr1:118207256..118207267 +
Hg19::chr1:154377675..154377692,+	p7@IL6R
Hg19::chr1:158900568..158900580,+	p4@PYHIN1
Hg19::chr1:169652514..169652517,+	p@chr1:169652514..169652517 +
Hg19::chr1:184861491..184861522,-	p@chr1:184861491..184861522 -
Hg19::chr1:186287725..186287734,-	p@chr1:186287725..186287734 -
Hg19::chr1:186290177..186290204,-	p@chr1:186290177..186290204 -
Hg19::chr1:186293145..186293167,-	p@chr1:186293145..186293167 -
Hg19::chr1:186293180..186293185,-	p@chr1:186293180..186293185 -
Hg19::chr1:193426391..193426402,+	p@chr1:193426391..193426402 +
Hg19::chr1:193428096..193428112,+	p@chr1:193428096..193428112 +
Hg19::chr1:193448401..193448412,-	p@chr1:193448401..193448412 -
Hg19::chr1:200842103..200842116,+	p1@GPR25
Hg19::chr1:25255894..25255906,+	p@chr1:25255894..25255906 +
Hg19::chr1:40854406..40854413,+	p@chr1:40854406..40854413 +
Hg19::chr1:8213538..8213546,-	p@chr1:8213538..8213546 -
Hg19::chr20:44521809..44521827,+	p11@CTSA
Hg19::chr20:4642112..4642117,+	p@chr20:4642112..4642117 +
Hg19::chr20:47438166..47438202,-	p@chr20:47438166..47438202 -
Hg19::chr20:57740067..57740074,+	p@chr20:57740067..57740074 +
Hg19::chr21:32568033..32568068,-	p@chr21:32568033..32568068 -
Hg19::chr21:47971523..47971557,+	p@chr21:47971523..47971557 +
Hg19::chr2:112224582..112224600,+	p@chr2:112224582..112224600 +
Hg19::chr2:158297507..158297544,-	p@chr2:158297507..158297544 -
Hg19::chr2:198562922..198562964,+	p@chr2:198562922..198562964 +
Hg19::chr2:204571443..204571454,+	p5@CD28
Hg19::chr2:204718698..204718703,+	p@chr2:204718698..204718703 +
Hg19::chr2:204732487..204732521,+	p1@CTLA4
Hg19::chr2:204732524..204732537,+	p3@CTLA4
Hg19::chr2:204732580..204732598,+	p2@CTLA4
Hg19::chr2:204732682..204732693,+	p4@CTLA4
Hg19::chr2:204736259..204736275,-	p@chr2:204736259..204736275 -
Hg19::chr2:204736545..204736556,+	p@chr2:204736545..204736556 +
Hg19::chr2:204891853..204891863,-	p@chr2:204891853..204891863 -
Hg19::chr2:213963849..213963858,-	p@chr2:213963849..213963858 -
Hg19::chr2:213963876..213963889,-	p@chr2:213963876..213963889 -
Hg19::chr2:214012337..214012351,-	p@chr2:214012337..214012351 -
Hg19::chr2:214012365..214012410,-	p@chr2:214012365..214012410 -
Hg19::chr2:241975597..241975616,+	p@chr2:241975597..241975616 +
Hg19::chr3:114012819..114012830,+	p4@TIGIT
Hg19::chr3:114012837..114012850,+	p2@TIGIT
Hg19::chr3:114012855..114012862,+	p5@TIGIT
Hg19::chr3:114012867..114012887,+	p1@TIGIT
Hg19::chr3:183067487..183067500,+	p@chr3:183067487..183067500 +
Hg19::chr3:183067510..183067522,+	p@chr3:183067510..183067522 +
Hg19::chr3:33086412..33086426,+	p@chr3:33086412..33086426 +
Hg19::chr3:45986539..45986570,+	p2@CXCR6
Hg19::chr3:56627780..56627823,+	p1@HQ234308
Hg19::chr3:60033427..60033438,+	p@chr3:60033427..60033438 +
Hg19::chr3:66353087..66353127,+	p@chr3:66353087..66353127 +
Hg19::chr3:66444556..66444563,-	p@chr3:66444556..66444563 -
Hg19::chr3:71551472..71551476,-	p@chr3:71551472..71551476 -
Hg19::chr3:73010101..73010107,+	p@chr3:73010101..73010107 +
Hg19::chr3:73015629..73015632,+	p@chr3:73015629..73015632 +
Hg19::chr4:78722513..78722551,-	p@chr4:78722513..78722551 -
Hg19::chr5:126189802..126189808,-	p@chr5:126189802..126189808 -
Hg19::chr5:67576339..67576353,+	p8@PIK3R1
Hg19::chr5:75839276..75839297,+	p@chr5:75839276..75839297 +
Hg19::chr5:96050863..96050877,+	p@chr5:96050863..96050877 +
Hg19::chr6:106546834..106546850,+	p4@PRDM1
Hg19::chr6:112078784..112078808,-	p@chr6:112078784..112078808 -
Hg19::chr6:138115457..138115471,+	p@chr6:138115457..138115471 +
Hg19::chr6:167525277..167525292,+	p3@CCR6
Hg19::chr6:167527544..167527563,-	p@chr6:167527544..167527563 -
Hg19::chr6:167527588..167527601,-	p@chr6:167527588..167527601 -
Hg19::chr6:167527627..167527634,-	p@chr6:167527627..167527634 -
Hg19::chr6:167527638..167527665,-	p@chr6:167527638..167527665 -
Hg19::chr6:167528231..167528238,+	p@chr6:167528231..167528238 +
Hg19::chr6:167533072..167533078,-	p@chr6:167533072..167533078 -
Hg19::chr6:167535904..167535935,+	p6@CCR6
Hg19::chr6:36922228..36922251,+	p5@PI16
Hg19::chr6:36922265..36922280,+	p4@PI16
Hg19::chr7:130623689..130623700,+	p@chr7:130623689..130623700 +
Hg19::chr7:130623728..130623739,+	p@chr7:130623728..130623739 +
Hg19::chr7:1966886..1966912,+	p@chr7:1966886..1966912 +
Hg19::chr7:1980103..1980127,-	p5@MAD1L1
Hg19::chr7:44663908..44663917,+	p6@OGDH
Hg19::chr7:5862938..5862949,+	p5@ZNF815
Hg19::chr7:8183804..8183812,-	p@chr7:8183804..8183812 -
Hg19::chr8:19372703..19372715,-	p@chr8:19372703..19372715 -
Hg19::chr8:29938837..29938842,+	p@chr8:29938837..29938842 +
Hg19::chr8:30013422..30013433,+	p4@DCTN6
Hg19::chr9:123640450..123640455,-	p@chr9:123640450..123640455 -
Hg19::chrY:23300437..23300442,+	p@chrY:23300437..23300442 +
Hg19::chrY:23300496..23300510,+	p@chrY:23300496..23300510 +
Hg19::chrY:23300512..23300525,+	p@chrY:23300512..23300525 +
Hg19::chrY:23300567..23300577,+	p@chrY:23300567..23300577 +
Hg19::chrY:23317687..23317689,+	p@chrY:23317687..23317689 +
Hg19::chrY:23411642..23411670,+	p@chrY:23411642..23411670 +
Hg19::chrY:23411694..23411707,+	p@chrY:23411694..23411707 +
Hg19::chrY:23411712..23411746,+	p@chrY:23411712..23411746 +
Hg19::chrY:23411747..23411768,+	p@chrY:23411747..23411768 +
Hg19::chrY:23416616..23416638,+	p@chrY:23416616..23416638 +
Hg19::chrY:23416642..23416670,+	p@chrY:23416642..23416670 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0042277	peptide binding	0.000964878835959757
GO:0005887	integral to plasma membrane	0.000964878835959757
GO:0031226	intrinsic to plasma membrane	0.000964878835959757
GO:0004945	angiotensin type II receptor activity	0.000964878835959757
GO:0001595	angiotensin receptor activity	0.000964878835959757
GO:0019955	cytokine binding	0.00179502772967683
GO:0015026	coreceptor activity	0.00229165706264122
GO:0008528	peptide receptor activity, G-protein coupled	0.00334468907473246
GO:0001653	peptide receptor activity	0.00334468907473246
GO:0019957	C-C chemokine binding	0.00334468907473246
GO:0016493	C-C chemokine receptor activity	0.00334468907473246
GO:0019079	viral genome replication	0.00450212279542765
GO:0004950	chemokine receptor activity	0.00582811155172879
GO:0001637	G-protein chemoattractant receptor activity	0.00582811155172879
GO:0044459	plasma membrane part	0.00582811155172879
GO:0019956	chemokine binding	0.00582811155172879
GO:0019058	viral infectious cycle	0.00889621518374608
GO:0022415	viral reproductive process	0.00889621518374608
GO:0050164	oxoglutarate dehydrogenase (NADP+) activity	0.00889621518374608
GO:0045209	MAPK phosphatase export from nucleus, leptomycin B sensitive	0.00889621518374608
GO:0005896	interleukin-6 receptor complex	0.00889621518374608
GO:0000093	mitotic telophase	0.00889621518374608
GO:0045204	MAPK export from nucleus	0.00889621518374608
GO:0051326	telophase	0.00889621518374608
GO:0035030	phosphoinositide 3-kinase complex, class IA	0.00889621518374608
GO:0045208	MAPK phosphatase export from nucleus	0.00889621518374608
GO:0004186	carboxypeptidase C activity	0.00889621518374608
GO:0007088	regulation of mitosis	0.0103676024692682
GO:0006959	humoral immune response	0.0125281501399269
GO:0019981	interleukin-6 binding	0.0150081649108715
GO:0004915	interleukin-6 receptor activity	0.0150081649108715
GO:0043559	insulin binding	0.0150081649108715
GO:0051323	metaphase	0.0211820727278141
GO:0000089	mitotic metaphase	0.0211820727278141
GO:0007166	cell surface receptor linked signal transduction	0.0252319048871694
GO:0045502	dynein binding	0.0259455531866042
GO:0043125	ErbB-3 class receptor binding	0.0259455531866042
GO:0051322	anaphase	0.02925966667654
GO:0000090	mitotic anaphase	0.02925966667654
GO:0043560	insulin receptor substrate binding	0.02925966667654
GO:0045070	positive regulation of viral genome replication	0.02925966667654
GO:0048524	positive regulation of viral reproduction	0.0381492264024993
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	0.0381492264024993
GO:0048009	insulin-like growth factor receptor signaling pathway	0.0381492264024993
GO:0005886	plasma membrane	0.0399546847062203
GO:0006955	immune response	0.0399546847062203
GO:0045768	positive regulation of anti-apoptosis	0.0399546847062203
GO:0005869	dynactin complex	0.0399546847062203
GO:0017046	peptide hormone binding	0.0431389984972692
GO:0035014	phosphoinositide 3-kinase regulator activity	0.0431389984972692
GO:0004888	transmembrane receptor activity	0.0435256927353548
GO:0007165	signal transduction	0.0470499784077165
GO:0005159	insulin-like growth factor receptor binding	0.0470499784077165
GO:0004185	serine carboxypeptidase activity	0.0470499784077165
GO:0016494	C-X-C chemokine receptor activity	0.0470499784077165
GO:0045086	positive regulation of interleukin-2 biosynthetic process	0.0470499784077165
GO:0045840	positive regulation of mitosis	0.0483246687840058
GO:0019958	C-X-C chemokine binding	0.0483246687840058
GO:0045767	regulation of anti-apoptosis	0.0483246687840058
GO:0004872	receptor activity	0.0483246687840058

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
leukocyte	2.25e-40	140
hematopoietic stem cell	1.70e-34	172
angioblastic mesenchymal cell	1.70e-34	172
hematopoietic lineage restricted progenitor cell	9.90e-33	124
nongranular leukocyte	1.39e-31	119
hematopoietic cell	2.02e-31	182
hematopoietic oligopotent progenitor cell	2.09e-31	165
hematopoietic multipotent progenitor cell	2.09e-31	165
lymphoid lineage restricted progenitor cell	6.44e-25	52
lymphocyte	1.07e-24	53
common lymphoid progenitor	1.07e-24	53
T cell	6.52e-15	25
pro-T cell	6.52e-15	25
CD14-positive, CD16-negative classical monocyte	2.81e-14	42
classical monocyte	2.57e-13	45
mature alpha-beta T cell	1.08e-12	18
alpha-beta T cell	1.08e-12	18
immature T cell	1.08e-12	18
mature T cell	1.08e-12	18
immature alpha-beta T cell	1.08e-12	18
myeloid leukocyte	1.56e-12	76
myeloid cell	1.27e-10	112
common myeloid progenitor	1.27e-10	112
myeloid lineage restricted progenitor cell	6.22e-10	70
granulocyte monocyte progenitor cell	1.25e-09	71
lymphocyte of B lineage	1.38e-09	24
pro-B cell	1.38e-09	24
macrophage dendritic cell progenitor	9.86e-09	65
CD8-positive, alpha-beta T cell	2.54e-08	11
monopoietic cell	3.01e-08	63
monocyte	3.01e-08	63
monoblast	3.01e-08	63
promonocyte	3.01e-08	63
B cell	5.43e-07	14

Uber Anatomy

Ontology term	p-value	n
adult organism	8.79e-20	115
hemolymphoid system	1.09e-16	112
hematopoietic system	3.91e-16	102
blood island	3.91e-16	102
immune system	2.76e-09	115
blood	3.20e-09	15
haemolymphatic fluid	3.20e-09	15
organism substance	3.20e-09	15
bone marrow	1.02e-07	80

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BATF#10538	15	1.99654113051669	0.00888804320844834	0.0337217402785315
BCL11A#53335	20	3.10048689656908	8.57593585582864e-06	0.000233063274745482
GATA2#2624	24	1.67146645685954	0.00926406328679017	0.0350034190372663

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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