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{{Coexpression_clusters
{{Coexpression_clusters
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|full_id=C1415_small_Hair_Mesenchymal_Preadipocyte_Fibroblast_duodenum_colon
|full_id=C1415_small_Hair_Mesenchymal_Preadipocyte_Fibroblast_duodenum_colon
|id=C1415
|id=C1415

Revision as of 13:58, 12 September 2012


Full id: C1415_small_Hair_Mesenchymal_Preadipocyte_Fibroblast_duodenum_colon



Phase1 CAGE Peaks

Hg19::chr15:90347724..90347746,+p@chr15:90347724..90347746
+
Hg19::chr15:90348362..90348394,+p@chr15:90348362..90348394
+
Hg19::chr15:90348572..90348598,+p@chr15:90348572..90348598
+
Hg19::chr15:90349575..90349613,+p@chr15:90349575..90349613
+
Hg19::chr15:90349614..90349663,+p@chr15:90349614..90349663
+
Hg19::chr15:90349664..90349706,+p@chr15:90349664..90349706
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
multi fate stem cell4.63e-26430
somatic stem cell9.08e-25436
somatic cell4.62e-24591
stem cell3.98e-23444
non-terminally differentiated cell1.76e-21180
fibroblast3.69e-1675
connective tissue cell5.65e-16365
muscle precursor cell1.27e-1457
myoblast1.27e-1457
multi-potent skeletal muscle stem cell1.27e-1457
mesenchymal cell6.88e-14358
contractile cell1.75e-1359
muscle cell4.80e-1354
mesodermal cell9.20e-13119
motile cell2.47e-11390
monopoietic cell1.19e-1063
monocyte1.19e-1063
monoblast1.19e-1063
promonocyte1.19e-1063
myeloid leukocyte3.31e-1076
smooth muscle cell3.72e-1042
smooth muscle myoblast3.72e-1042
macrophage dendritic cell progenitor4.68e-1065
skin fibroblast7.82e-1023
animal cell1.11e-09679
eukaryotic cell1.11e-09679
electrically responsive cell1.35e-0960
electrically active cell1.35e-0960
myeloid lineage restricted progenitor cell4.72e-0970
granulocyte monocyte progenitor cell2.17e-0871
CD14-positive, CD16-negative classical monocyte2.80e-0842
vascular associated smooth muscle cell5.92e-0832
classical monocyte9.11e-0745
Uber Anatomy
Ontology termp-valuen
musculoskeletal system8.74e-23167
mesoderm2.82e-19448
mesoderm-derived structure2.82e-19448
presumptive mesoderm2.82e-19448
dermomyotome1.70e-1770
somite4.04e-1783
paraxial mesoderm4.04e-1783
presomitic mesoderm4.04e-1783
presumptive segmental plate4.04e-1783
trunk paraxial mesoderm4.04e-1783
presumptive paraxial mesoderm4.04e-1783
lateral plate mesoderm5.18e-16216
connective tissue9.83e-16375
trunk mesenchyme2.48e-14143
muscle tissue1.59e-1363
musculature1.59e-1363
musculature of body1.59e-1363
multilaminar epithelium2.04e-1382
cardiovascular system3.24e-13110
skeletal muscle tissue4.55e-1361
striated muscle tissue4.55e-1361
myotome4.55e-1361
circulatory system1.39e-12113
vasculature3.68e-1279
vascular system3.68e-1279
unilaminar epithelium6.10e-11138
blood vessel3.59e-1060
epithelial tube open at both ends3.59e-1060
blood vasculature3.59e-1060
vascular cord3.59e-1060
vessel4.65e-1069
immune system4.97e-10115
epithelial tube1.62e-09118
multi-cellular organism1.66e-09659
bone marrow2.15e-0980
anatomical system2.15e-09625
artery2.61e-0942
arterial blood vessel2.61e-0942
arterial system2.61e-0942
hemolymphoid system2.65e-09112
anatomical group3.30e-09626
splanchnic layer of lateral plate mesoderm3.48e-0984
hematopoietic system5.95e-09102
blood island5.95e-09102
tissue6.15e-09787
skeletal element1.19e-08101
skeletal system1.19e-08101
systemic artery1.20e-0833
systemic arterial system1.20e-0833
trunk2.93e-08216
bone element4.06e-0886
integument4.81e-0845
integumental system4.81e-0845
adipose tissue6.73e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.