Coexpression cluster:C429

Full id: C429_anaplastic_Mast_clear_Neutrophils_squamous_Eosinophils_oral

Phase1 CAGE Peaks

Hg19::chr10:28367018..28367027,+	p@chr10:28367018..28367027 +
Hg19::chr10:28367095..28367106,+	p@chr10:28367095..28367106 +
Hg19::chr10:28367218..28367230,+	p@chr10:28367218..28367230 +
Hg19::chr10:28367236..28367266,+	p@chr10:28367236..28367266 +
Hg19::chr10:28367270..28367278,+	p@chr10:28367270..28367278 +
Hg19::chr12:127256858..127256871,-	p1@ENST00000542248
Hg19::chr16:56648492..56648498,-	p@chr16:56648492..56648498 -
Hg19::chr16:56648503..56648510,-	p@chr16:56648503..56648510 -
Hg19::chr16:56648532..56648539,-	p@chr16:56648532..56648539 -
Hg19::chr17:31099607..31099657,-	p@chr17:31099607..31099657 -
Hg19::chr20:32951056..32951067,+	p2@ITCH
Hg19::chr20:32951070..32951122,+	p1@ITCH
Hg19::chr21:19858196..19858204,-	p2@TMPRSS15
Hg19::chr2:17603261..17603273,-	p@chr2:17603261..17603273 -
Hg19::chr2:26915639..26915654,+	p3@KCNK3
Hg19::chr4:20253897..20253905,+	p@chr4:20253897..20253905 +
Hg19::chr8:33330595..33330689,-	p1@FUT10
Hg19::chr8:33370607..33370676,-	p1@TTI2
Hg19::chr8:33744758..33744766,-	p@chr8:33744758..33744766 -
Hg19::chr8:33744817..33744827,-	p@chr8:33744817..33744827 -
Hg19::chr8:55467072..55467091,+	p1@ENST00000518787
Hg19::chr9:106503385..106503391,-	p@chr9:106503385..106503391 -
Hg19::chr9:114714967..114714986,-	p@chr9:114714967..114714986 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0022414	reproductive process	0.00996864124799369
GO:0009611	response to wounding	0.00996864124799369
GO:0046920	alpha(1,3)-fucosyltransferase activity	0.00996864124799369
GO:0044265	cellular macromolecule catabolic process	0.00996864124799369
GO:0019317	fucose catabolic process	0.00996864124799369
GO:0042355	L-fucose catabolic process	0.00996864124799369
GO:0044409	entry into host	0.00996864124799369
GO:0030260	entry into host cell	0.00996864124799369
GO:0042354	L-fucose metabolic process	0.00996864124799369
GO:0019059	initiation of viral infection	0.00996864124799369
GO:0052192	movement in environment of other organism during symbiotic interaction	0.00996864124799369
GO:0046718	entry of virus into host cell	0.00996864124799369
GO:0052126	movement in host environment	0.00996864124799369
GO:0051828	entry into other organism during symbiotic interaction	0.00996864124799369
GO:0051806	entry into cell of other organism during symbiotic interaction	0.00996864124799369
GO:0009057	macromolecule catabolic process	0.00996864124799369
GO:0009605	response to external stimulus	0.00996864124799369
GO:0006004	fucose metabolic process	0.0121373491035594
GO:0008417	fucosyltransferase activity	0.0137966119781209
GO:0044248	cellular catabolic process	0.0137966119781209
GO:0051701	interaction with host	0.0152552373701995
GO:0009056	catabolic process	0.0180874098061372
GO:0044403	symbiosis, encompassing mutualism through parasitism	0.0194100405888146
GO:0044419	interspecies interaction between organisms	0.0194100405888146
GO:0006950	response to stress	0.0249860686985649
GO:0019058	viral infectious cycle	0.0279804151465854
GO:0022415	viral reproductive process	0.0301318038301384
GO:0009566	fertilization	0.0301318038301384

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
adult organism	2.56e-14	115
anterior region of body	7.53e-10	129
craniocervical region	7.53e-10	129
organism subdivision	1.62e-09	365
head	4.76e-09	123
brain	1.62e-08	69
future brain	1.62e-08	69
neural tube	1.62e-08	57
neural rod	1.62e-08	57
future spinal cord	1.62e-08	57
neural keel	1.62e-08	57
ectoderm	1.02e-07	173
presumptive ectoderm	1.02e-07	173
ectoderm-derived structure	1.98e-07	169
neurectoderm	3.07e-07	90
central nervous system	3.17e-07	82
regional part of brain	3.66e-07	59
anterior neural tube	4.82e-07	42
neural plate	5.86e-07	86
presumptive neural plate	5.86e-07	86
regional part of nervous system	7.15e-07	94
nervous system	7.15e-07	94
regional part of forebrain	9.14e-07	41
forebrain	9.14e-07	41
future forebrain	9.14e-07	41

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BATF#10538	4	4.23613944213976	0.0134457584803093	0.0475006450605496
ESR1#2099	5	6.68882680351184	0.000746053914612315	0.00587477379086146

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.