Coexpression cluster:C4749

Full id: C4749_Mesenchymal_Hepatic_sacrococcigeal_rhabdomyosarcoma_Smooth_Trabecular_Fibroblast

Phase1 CAGE Peaks

Hg19::chr8:37654369..37654415,+	p1@GPR124
Hg19::chr8:37654427..37654436,+	p3@GPR124
Hg19::chr8:37654457..37654468,+	p2@GPR124

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	2.75e-31	180
fibroblast	1.85e-19	75
contractile cell	1.03e-11	59
muscle cell	1.05e-10	54
muscle precursor cell	1.66e-10	57
myoblast	1.66e-10	57
multi-potent skeletal muscle stem cell	1.66e-10	57
smooth muscle cell	3.50e-09	42
smooth muscle myoblast	3.50e-09	42
electrically responsive cell	7.12e-09	60
electrically active cell	7.12e-09	60
skin fibroblast	4.76e-08	23
mesodermal cell	3.39e-07	119

Uber Anatomy

Ontology term	p-value	n
multi-cellular organism	3.59e-15	659
somite	4.21e-13	83
paraxial mesoderm	4.21e-13	83
presomitic mesoderm	4.21e-13	83
presumptive segmental plate	4.21e-13	83
trunk paraxial mesoderm	4.21e-13	83
presumptive paraxial mesoderm	4.21e-13	83
splanchnic layer of lateral plate mesoderm	3.90e-12	84
dermomyotome	4.38e-12	70
vasculature	6.99e-12	79
vascular system	6.99e-12	79
muscle tissue	2.03e-11	63
musculature	2.03e-11	63
musculature of body	2.03e-11	63
organism subdivision	6.44e-11	365
skeletal muscle tissue	8.15e-11	61
striated muscle tissue	8.15e-11	61
myotome	8.15e-11	61
circulatory system	1.41e-10	113
cardiovascular system	1.77e-10	110
anatomical system	7.96e-10	625
anatomical group	8.96e-10	626
trunk mesenchyme	1.09e-09	143
multilaminar epithelium	1.65e-09	82
vessel	2.09e-09	69
blood vessel	8.54e-09	60
epithelial tube open at both ends	8.54e-09	60
blood vasculature	8.54e-09	60
vascular cord	8.54e-09	60
embryo	1.05e-07	612
embryonic structure	2.75e-07	605
developing anatomical structure	2.75e-07	605
epithelial tube	4.10e-07	118
germ layer	5.19e-07	604
embryonic tissue	5.19e-07	604
presumptive structure	5.19e-07	604
epiblast (generic)	5.19e-07	604
tissue	5.45e-07	787
multi-tissue structure	9.58e-07	347

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CCNT2#905	3	6.33620157696263	0.00393075003576489	0.0191279285707413
CTCF#10664	3	5.36025637307503	0.006492509252767	0.0281485812549186
E2F1#1869	3	4.90738921487932	0.00846098534723939	0.0327911848256024
E2F6#1876	3	5.01715573169739	0.0079176980688633	0.032452276936306
EGR1#1958	3	4.98817909481014	0.00805648813738344	0.0322664249944468
FOSL1#8061	3	39.713579716373	1.59554825631833e-05	0.000372790747967853
JUND#3727	3	6.99466394187103	0.00292184504273499	0.0157735229204073
TFAP2A#7020	3	16.518634373045	0.000221803388076634	0.0024964892819631
TFAP2C#7022	3	10.8092286098602	0.000791674657575313	0.00619245877490324
ZBTB7A#51341	3	7.3519093078759	0.00251625586028227	0.0141014834616881
ZNF143#7702	3	13.5008765522279	0.000406280496299717	0.00390570036386654

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.