Coexpression cluster:C803

Full id: C803_Macrophage_CD14_Monocytederived_Eosinophils_Basophils_CD14CD16_Dendritic

Phase1 CAGE Peaks

Hg19::chr11:58980342..58980431,-	p1@MPEG1
Hg19::chr13:51289225..51289244,-	p@chr13:51289225..51289244 -
Hg19::chr14:103587774..103587784,+	p@chr14:103587774..103587784 +
Hg19::chr15:51914996..51915035,-	p2@DMXL2
Hg19::chr20:1472164..1472175,-	p3@SIRPB2
Hg19::chr5:140012540..140012567,-	p8@CD14
Hg19::chr5:140012752..140012768,-	p1@CD14
Hg19::chr5:140012773..140012794,-	p2@CD14
Hg19::chr7:139529007..139529038,+	p3@TBXAS1
Hg19::chrX:37639302..37639326,+	p1@CYBB

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0009611	response to wounding	0.00259656563361436
GO:0009605	response to external stimulus	0.00432029297768241
GO:0004796	thromboxane-A synthase activity	0.0135397656327913
GO:0006950	response to stress	0.0151692776269214
GO:0006954	inflammatory response	0.016921717954316
GO:0016019	peptidoglycan receptor activity	0.016921717954316
GO:0042834	peptidoglycan binding	0.0203000847796423
GO:0046457	prostanoid biosynthetic process	0.0203000847796423
GO:0002237	response to molecule of bacterial origin	0.0203000847796423
GO:0001516	prostaglandin biosynthetic process	0.0203000847796423
GO:0008329	pattern recognition receptor activity	0.0221429395266416
GO:0005506	iron ion binding	0.0244276827821287
GO:0006693	prostaglandin metabolic process	0.0245847341859006
GO:0006692	prostanoid metabolic process	0.0245847341859006
GO:0044459	plasma membrane part	0.0245847341859006
GO:0006952	defense response	0.0245847341859006
GO:0017137	Rab GTPase binding	0.0322090574849813
GO:0006118	electron transport	0.0334093525836169
GO:0046456	icosanoid biosynthetic process	0.0352103301235468
GO:0006909	phagocytosis	0.0415392895817162
GO:0045121	lipid raft	0.0421923624208418
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	0.0421923624208418
GO:0006091	generation of precursor metabolites and energy	0.0421923624208418
GO:0006690	icosanoid metabolic process	0.0421923624208418

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
leukocyte	1.18e-33	140
myeloid leukocyte	4.25e-33	76
hematopoietic stem cell	2.97e-31	172
angioblastic mesenchymal cell	2.97e-31	172
nongranular leukocyte	4.57e-29	119
granulocyte monocyte progenitor cell	6.08e-29	71
hematopoietic oligopotent progenitor cell	7.04e-29	165
hematopoietic multipotent progenitor cell	7.04e-29	165
macrophage dendritic cell progenitor	1.88e-28	65
hematopoietic lineage restricted progenitor cell	2.38e-28	124
myeloid lineage restricted progenitor cell	3.60e-28	70
monopoietic cell	3.76e-28	63
monocyte	3.76e-28	63
monoblast	3.76e-28	63
promonocyte	3.76e-28	63
hematopoietic cell	2.07e-27	182
CD14-positive, CD16-negative classical monocyte	3.01e-27	42
myeloid cell	4.18e-26	112
common myeloid progenitor	4.18e-26	112
classical monocyte	8.61e-24	45
mesenchymal cell	7.26e-08	358
connective tissue cell	2.02e-07	365

Uber Anatomy

Ontology term	p-value	n
adult organism	1.39e-37	115
hematopoietic system	1.78e-31	102
blood island	1.78e-31	102
hemolymphoid system	2.77e-29	112
bone marrow	6.70e-25	80
immune system	6.23e-24	115
bone element	5.16e-21	86
skeletal element	2.41e-16	101
skeletal system	2.41e-16	101
neural tube	4.87e-11	57
neural rod	4.87e-11	57
future spinal cord	4.87e-11	57
neural keel	4.87e-11	57
lateral plate mesoderm	5.34e-10	216
anterior neural tube	1.45e-09	42
regional part of brain	2.71e-09	59
regional part of forebrain	3.16e-09	41
forebrain	3.16e-09	41
future forebrain	3.16e-09	41
tissue	1.24e-08	787
gray matter	8.68e-08	34
brain grey matter	8.68e-08	34
brain	9.33e-08	69
future brain	9.33e-08	69
telencephalon	9.86e-08	34
regional part of telencephalon	1.66e-07	33
musculoskeletal system	2.15e-07	167
connective tissue	3.19e-07	375
cerebral hemisphere	5.13e-07	32

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.