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MCL coexpression mm9:1893: Difference between revisions

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{{MCL_coexpression_mm9
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protein kinase inhibitor activity;0.0121617179066112;18768!GO:0004860;protein kinase inhibitor activity;0.0256501195402001;18768!GO:0019210;kinase inhibitor activity;0.0256501195402001;18768!GO:0006469;negative regulation of protein kinase activity;0.0256501195402001;18768!GO:0033673;negative regulation of kinase activity;0.0256501195402001;18768!GO:0051348;negative regulation of transferase activity;0.0256501195402001;18768!GO:0043086;negative regulation of catalytic activity;0.0271862726864854;18768!GO:0019887;protein kinase regulator activity;0.0318720337344778;18768!GO:0019207;kinase regulator activity;0.0332672814824209;18768!GO:0045859;regulation of protein kinase activity;0.0454415183000368;18768!GO:0043549;regulation of kinase activity;0.0454415183000368;18768!GO:0051338;regulation of transferase 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|gostat_on_MCL_coexpression=GO:0004862;cAMP-dependent protein kinase inhibitor activity;0.0121617179066112;18768!GO:0004860;protein kinase inhibitor activity;0.0256501195402001;18768!GO:0019210;kinase inhibitor activity;0.0256501195402001;18768!GO:0006469;negative regulation of protein kinase activity;0.0256501195402001;18768!GO:0033673;negative regulation of kinase activity;0.0256501195402001;18768!GO:0051348;negative regulation of transferase activity;0.0256501195402001;18768!GO:0043086;negative regulation of catalytic activity;0.0271862726864854;18768!GO:0019887;protein kinase regulator activity;0.0318720337344778;18768!GO:0019207;kinase regulator activity;0.0332672814824209;18768!GO:0045859;regulation of protein kinase activity;0.0454415183000368;18768!GO:0043549;regulation of kinase activity;0.0454415183000368;18768!GO:0051338;regulation of transferase activity;0.0454415183000368;18768!
|ontology_enrichment_celltype=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000073!3.45e-12!54;UBERON:0002346!1.59e-11!64;UBERON:0003075!1.59e-11!64;UBERON:0007284!1.59e-11!64;UBERON:0010371!3.01e-11!73;UBERON:0001049!3.62e-11!52;UBERON:0005068!3.62e-11!52;UBERON:0006241!3.62e-11!52;UBERON:0007135!3.62e-11!52;UBERON:0000955!2.13e-09!47;UBERON:0006238!2.13e-09!47;UBERON:0004121!3.36e-09!95;UBERON:0000924!3.36e-09!95;UBERON:0006601!3.36e-09!95;UBERON:0003056!4.20e-09!49;UBERON:0002616!7.41e-09!46;UBERON:0001017!3.30e-08!73;UBERON:0001016!3.34e-08!75;UBERON:0002020!5.48e-08!34;UBERON:0003080!1.98e-07!40;UBERON:0007023!3.73e-07!51;UBERON:0002780!6.87e-07!39;UBERON:0001890!6.87e-07!39;UBERON:0006240!6.87e-07!39
|tfbs_overrepresentation_for_novel_motifs=0.641384,0.801438,0.612053,0.688265,0.483253,0.704257,1.88411,0.370124,0.381467,0.949265,0.755749,0.790506,0.96877,0.81685,0.502646,0,1.02248,0.473993,0.352304,1.96325,0.570433,0.197567,0.815872,0.481455,0.620553,0.846564,0.342316,0.727368,3.35169,2.2033,0.711848,1.12823,0.471365,0.854272,0.503207,0.089443,2.02937,0.786577,0.434783,0.40068,0.478558,0.717547,0.544696,0.504971,0.325217,0.675898,0.938241,0.744678,0.949442,0.539131,1.0041,0.875451,0.771943,1.2746,1.29252,0.82458,0.549352,0.776619,0.331485,0.822375,1.10737,0.885556,0.39557,0.992216,0.8366,1.03484,1.43193,1.78579,1.1025,1.63712,1.44172,0.98374,0.205546,1.32691,0.864765,0.310084,0.318792,0.926147,1.08947,0.575233,0.986898,1.04072,0.884013,0.362446,1.20828,0.377699,0.129654,0.290918,0.943446,1.94914,1.50286,1.21342,1.14153,0.490141,0.430015,0.409166,1.71135,1.14445,0.938512,0.264911,0.460566,1.12793,1.25667,1.00472,1.00361,0.717061,1.06633,0.740267,0.580757,1.4032,0.633483,1.25851,2.41172,0.7614,1.51002,0.476467,0.442329,0.692434,1.02384,0.456123,1.33244,0.970073,0.848526,0.925183,1.56496,1.09333,0.812403,1.13449,1.43038,0.493609,1.23918,0.680176,1.40022,0.839311,1.53196,3.19361,2.65107,0.719099,1.482,2.31884,1.91709,1.43673,0.861473,1.1391,0.996781,0.718046,0.941555,2.27909,1.57302,3.12538,1.4513,0.542121,1.27621,0.416214,0.838313,1.35996,0.87653,1.28473,0.63863,0.650472,1.49167,1.20739,1.09379,1.52606,0.993294,0.830321,0.459159,1.85366,0.992915
|tfbs_overrepresentation_jaspar=MA0003.1;1.34944,MA0004.1;0.6888,MA0006.1;0.497533,MA0007.1;0.672186,MA0009.1;1.15569,MA0014.1;2.01483,MA0017.1;0.528196,MA0019.1;0.964875,MA0024.1;1.11019,MA0025.1;1.39562,MA0027.1;2.81824,MA0028.1;0.509589,MA0029.1;1.08753,MA0030.1;1.09438,MA0031.1;1.05719,MA0038.1;0.846479,MA0040.1;1.16866,MA0041.1;0.604221,MA0042.1;0.589368,MA0043.1;1.25564,MA0046.1;1.1929,MA0048.1;2.07944,MA0050.1;0.731539,MA0051.1;0.856094,MA0052.1;1.17701,MA0055.1;0.790894,MA0056.1;0,MA0057.1;0.251896,MA0058.1;0.581673,MA0059.1;0.59559,MA0060.1;0.403071,MA0061.1;0.438628,MA0063.1;0,MA0066.1;0.834648,MA0067.1;1.50873,MA0068.1;0.256913,MA0069.1;1.17737,MA0070.1;1.16732,MA0071.1;0.73062,MA0072.1;1.15853,MA0073.1;0.00221226,MA0074.1;0.795862,MA0076.1;0.550092,MA0077.1;1.13603,MA0078.1;0.891476,MA0081.1;0.621611,MA0083.1;1.25482,MA0084.1;1.84013,MA0087.1;1.21037,MA0088.1;0.201215,MA0089.1;0,MA0090.1;0.650768,MA0091.1;0.703314,MA0092.1;0.651119,MA0093.1;0.519148,MA0095.1;0,MA0098.1;0,MA0100.1;0.783305,MA0101.1;0.605676,MA0103.1;0.540576,MA0105.1;0.313353,MA0106.1;0.899777,MA0107.1;0.533522,MA0108.2;0.989014,MA0109.1;0,MA0111.1;0.666525,MA0113.1;0.869608,MA0114.1;0.43587,MA0115.1;1.25852,MA0116.1;0.497293,MA0117.1;1.22527,MA0119.1;0.606338,MA0122.1;1.24573,MA0124.1;1.45461,MA0125.1;1.37907,MA0130.1;0,MA0131.1;0.960068,MA0132.1;0,MA0133.1;0,MA0135.1;1.29308,MA0136.1;0.817395,MA0139.1;0.957842,MA0140.1;0.78318,MA0141.1;0.563066,MA0142.1;1.04199,MA0143.1;0.887119,MA0144.1;1.11951,MA0145.1;1.79187,MA0146.1;0.313734,MA0147.1;0.453952,MA0148.1;0.706718,MA0149.1;0.611881,MA0062.2;0.319836,MA0035.2;0.788288,MA0039.2;0.45096,MA0138.2;0.951653,MA0002.2;0.368961,MA0137.2;0.559766,MA0104.2;0.386166,MA0047.2;0.845655,MA0112.2;0.608441,MA0065.2;0.212467,MA0150.1;0.67206,MA0151.1;0,MA0152.1;0.84577,MA0153.1;1.31015,MA0154.1;2.88028,MA0155.1;0.230016,MA0156.1;0.549102,MA0157.1;1.0083,MA0158.1;0,MA0159.1;0.465802,MA0160.1;0.71003,MA0161.1;0,MA0162.1;1.16288,MA0163.1;1.64105,MA0164.1;0.817786,MA0080.2;0.534538,MA0018.2;0.828253,MA0099.2;0.944966,MA0079.2;0.190089,MA0102.2;1.8929,MA0258.1;0.419871,MA0259.1;0.441366,MA0442.1;0
}}

Latest revision as of 17:40, 17 September 2013


Phase1 CAGE Peaks

 Short description
Mm9::chr10:57351852..57351866,+p3@Pkib
Mm9::chr10:57351868..57351907,+p1@Pkib
Mm9::chr10:57351914..57351926,+p5@Pkib
Mm9::chr12:99813245..99813258,-p6@Kcnk10


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0004862cAMP-dependent protein kinase inhibitor activity0.0121617179066112
GO:0004860protein kinase inhibitor activity0.0256501195402001
GO:0019210kinase inhibitor activity0.0256501195402001
GO:0006469negative regulation of protein kinase activity0.0256501195402001
GO:0033673negative regulation of kinase activity0.0256501195402001
GO:0051348negative regulation of transferase activity0.0256501195402001
GO:0043086negative regulation of catalytic activity0.0271862726864854
GO:0019887protein kinase regulator activity0.0318720337344778
GO:0019207kinase regulator activity0.0332672814824209
GO:0045859regulation of protein kinase activity0.0454415183000368
GO:0043549regulation of kinase activity0.0454415183000368
GO:0051338regulation of transferase activity0.0454415183000368



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
regional part of nervous system3.45e-1254
neurectoderm1.59e-1164
neural plate1.59e-1164
presumptive neural plate1.59e-1164
ecto-epithelium3.01e-1173
neural tube3.62e-1152
neural rod3.62e-1152
future spinal cord3.62e-1152
neural keel3.62e-1152
brain2.13e-0947
future brain2.13e-0947
ectoderm-derived structure3.36e-0995
ectoderm3.36e-0995
presumptive ectoderm3.36e-0995
pre-chordal neural plate4.20e-0949
regional part of brain7.41e-0946
central nervous system3.30e-0873
nervous system3.34e-0875
gray matter5.48e-0834
anterior neural tube1.98e-0740
adult organism3.73e-0751
regional part of forebrain6.87e-0739
forebrain6.87e-0739
future forebrain6.87e-0739


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.11.34944
MA0004.10.6888
MA0006.10.497533
MA0007.10.672186
MA0009.11.15569
MA0014.12.01483
MA0017.10.528196
MA0019.10.964875
MA0024.11.11019
MA0025.11.39562
MA0027.12.81824
MA0028.10.509589
MA0029.11.08753
MA0030.11.09438
MA0031.11.05719
MA0038.10.846479
MA0040.11.16866
MA0041.10.604221
MA0042.10.589368
MA0043.11.25564
MA0046.11.1929
MA0048.12.07944
MA0050.10.731539
MA0051.10.856094
MA0052.11.17701
MA0055.10.790894
MA0056.10
MA0057.10.251896
MA0058.10.581673
MA0059.10.59559
MA0060.10.403071
MA0061.10.438628
MA0063.10
MA0066.10.834648
MA0067.11.50873
MA0068.10.256913
MA0069.11.17737
MA0070.11.16732
MA0071.10.73062
MA0072.11.15853
MA0073.10.00221226
MA0074.10.795862
MA0076.10.550092
MA0077.11.13603
MA0078.10.891476
MA0081.10.621611
MA0083.11.25482
MA0084.11.84013
MA0087.11.21037
MA0088.10.201215
MA0089.10
MA0090.10.650768
MA0091.10.703314
MA0092.10.651119
MA0093.10.519148
MA0095.10
MA0098.10
MA0100.10.783305
MA0101.10.605676
MA0103.10.540576
MA0105.10.313353
MA0106.10.899777
MA0107.10.533522
MA0108.20.989014
MA0109.10
MA0111.10.666525
MA0113.10.869608
MA0114.10.43587
MA0115.11.25852
MA0116.10.497293
MA0117.11.22527
MA0119.10.606338
MA0122.11.24573
MA0124.11.45461
MA0125.11.37907
MA0130.10
MA0131.10.960068
MA0132.10
MA0133.10
MA0135.11.29308
MA0136.10.817395
MA0139.10.957842
MA0140.10.78318
MA0141.10.563066
MA0142.11.04199
MA0143.10.887119
MA0144.11.11951
MA0145.11.79187
MA0146.10.313734
MA0147.10.453952
MA0148.10.706718
MA0149.10.611881
MA0062.20.319836
MA0035.20.788288
MA0039.20.45096
MA0138.20.951653
MA0002.20.368961
MA0137.20.559766
MA0104.20.386166
MA0047.20.845655
MA0112.20.608441
MA0065.20.212467
MA0150.10.67206
MA0151.10
MA0152.10.84577
MA0153.11.31015
MA0154.12.88028
MA0155.10.230016
MA0156.10.549102
MA0157.11.0083
MA0158.10
MA0159.10.465802
MA0160.10.71003
MA0161.10
MA0162.11.16288
MA0163.11.64105
MA0164.10.817786
MA0080.20.534538
MA0018.20.828253
MA0099.20.944966
MA0079.20.190089
MA0102.21.8929
MA0258.10.419871
MA0259.10.441366
MA0442.10
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