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Coexpression cluster:C1826

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Full id: C1826_Neutrophils_parietal_lung_occipital_cerebellum_temporal_CD4



Phase1 CAGE Peaks

Hg19::chr19:53606636..53606692,-p1@ZNF160
Hg19::chr2:37311445..37311534,-p1@HEATR5B
Hg19::chr3:101232019..101232063,-p1@SENP7
Hg19::chr5:93447333..93447386,-p1@FAM172A
Hg19::chr6:111804393..111804436,-p2@REV3L


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0016035zeta DNA polymerase complex0.00447427293064877
GO:0003894zeta DNA polymerase activity0.00447427293064877
GO:0042575DNA polymerase complex0.00671081671889418
GO:0016925protein sumoylation0.00671081671889418



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism2.96e-35115
neural tube1.21e-1757
neural rod1.21e-1757
future spinal cord1.21e-1757
neural keel1.21e-1757
central nervous system5.42e-1682
anterior neural tube3.29e-1542
regional part of forebrain4.80e-1541
forebrain4.80e-1541
future forebrain4.80e-1541
brain8.13e-1569
future brain8.13e-1569
regional part of brain1.94e-1459
regional part of nervous system9.37e-1494
nervous system9.37e-1494
telencephalon3.62e-1234
gray matter4.59e-1234
brain grey matter4.59e-1234
regional part of telencephalon7.81e-1233
cerebral hemisphere2.29e-1132
neurectoderm2.29e-1090
neural plate9.56e-1086
presumptive neural plate9.56e-1086
regional part of cerebral cortex2.17e-0922
cerebral cortex4.34e-0925
pallium4.34e-0925
neocortex7.82e-0920
pre-chordal neural plate8.74e-0761


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105146.376918100659850.001113944176677320.00765389578078962
E2F6#187644.013724585357910.006632118233933880.0282992235754952
EGR1#195843.990543275848110.0067800983001440.0287684523591752
ELF1#199754.258097958807540.0007142416939776840.00573408319450652
ELK4#2005412.98854532677446.83810524411663e-050.00109099430734845
ETS1#211347.783008737761870.0005121035947688870.00444105184207156
GABPB1#255357.067683836182175.6685482528729e-050.000948593992920674
HEY1#2346254.040111043105710.0009288852205177990.00674489630436337
MYC#460944.177825497287520.005691969036823440.0256843186103609
NR2C2#7182213.04584436209630.00883636412768260.0335476038071556
POU2F2#545235.463674434645510.01115650094469780.0410142490817448
REST#597835.790017229676810.009468788694433940.0357020405956167
SIN3A#2594255.408884726815140.0002159522671657270.00248171642061195
TAF1#687253.343046285745290.002394600090870310.013542515778979
ZBTB33#10009212.66589001199250.009357016059651590.0353405685033253



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.