MCL coexpression mm9:376

Phase1 CAGE Peaks

	Short description
Mm9::chr10:127896024..127896045,+	p3@Smarcc2
Mm9::chr11:116029452..116029519,-	p1@Fbf1
Mm9::chr11:98590715..98590746,-	p1@Med24
Mm9::chr12:103996146..103996164,+	p2@Ubr7
Mm9::chr13:24893006..24893027,+	p2@BC005537
Mm9::chr15:81230210..81230221,-	p5@St13
Mm9::chr17:35301805..35301834,-	p1@Prrc2a
Mm9::chr17:35301836..35301846,-	p3@Prrc2a
Mm9::chr18:52927990..52928041,+	p2@Sncaip
Mm9::chr2:166888481..166888548,-	p3@Znfx1
Mm9::chr4:119088076..119088092,-	p3@Ccdc30
Mm9::chr4:137549360..137549389,+	p1@Eif4g3
Mm9::chr6:18798452..18798538,-	p@chr6:18798452..18798538 -
Mm9::chr7:13466514..13466553,+	p1@Zfp128
Mm9::chr7:147222262..147222299,-	p1@Tubgcp2
Mm9::chr8:125778047..125778068,-	p3@1300018I17Rik
Mm9::chr8:23763866..23763877,-	p2@Polb
Mm9::chr9:110019883..110019949,-	p1@Dhx30
Mm9::chr9:55785981..55786009,-	p2@Scaper
Mm9::chr9:60535684..60535753,-	p1@Lrrc49

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005874	microtubule	0.0236413058708681
GO:0005819	spindle	0.0236413058708681
GO:0015630	microtubule cytoskeleton	0.0432354923872047
GO:0003890	beta DNA polymerase activity	0.0452172912017236
GO:0017125	deoxycytidyl transferase activity	0.0452172912017236

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	9.62e-14	23
neuroblast (sensu Vertebrata)	9.62e-14	23
neuron	1.18e-12	33
neuronal stem cell	1.18e-12	33
neuroblast	1.18e-12	33
electrically signaling cell	1.18e-12	33
neural cell	1.09e-08	43
ectodermal cell	1.34e-08	44
neurectodermal cell	1.34e-08	44
electrically responsive cell	1.64e-08	39
electrically active cell	1.64e-08	39

Uber Anatomy

Ontology term	p-value	n
neurectoderm	9.17e-27	64
neural plate	9.17e-27	64
presumptive neural plate	9.17e-27	64
central nervous system	1.36e-25	73
regional part of nervous system	1.75e-24	54
nervous system	3.47e-24	75
ectoderm-derived structure	4.34e-24	95
ectoderm	4.34e-24	95
presumptive ectoderm	4.34e-24	95
ecto-epithelium	5.13e-24	73
neural tube	1.92e-23	52
neural rod	1.92e-23	52
future spinal cord	1.92e-23	52
neural keel	1.92e-23	52
pre-chordal neural plate	1.23e-21	49
brain	9.51e-21	47
future brain	9.51e-21	47
regional part of brain	4.23e-20	46
anterior neural tube	1.06e-18	40
structure with developmental contribution from neural crest	1.29e-18	92
regional part of forebrain	4.12e-18	39
forebrain	4.12e-18	39
future forebrain	4.12e-18	39
gray matter	5.34e-17	34
brain grey matter	1.79e-14	29
regional part of telencephalon	1.79e-14	29
telencephalon	1.79e-14	29
cerebral cortex	2.74e-10	21
cerebral hemisphere	2.74e-10	21
pallium	2.74e-10	21
regional part of cerebral cortex	6.88e-08	17
multi-cellular organism	9.69e-07	333

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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