MCL coexpression mm9:631

Phase1 CAGE Peaks

	Short description
Mm9::chr10:110991047..110991081,+	p@chr10:110991047..110991081 +
Mm9::chr16:65521021..65521032,+	p2@Pou1f1
Mm9::chr2:157397171..157397183,-	p14@Blcap
Mm9::chr2:163862718..163862732,+	p4@Pabpc1l
Mm9::chr2:26060097..26060110,-	p@chr2:26060097..26060110 -
Mm9::chr2:26060131..26060142,-	p@chr2:26060131..26060142 -
Mm9::chr2:26060145..26060156,-	p@chr2:26060145..26060156 -
Mm9::chr2:26060176..26060181,-	p@chr2:26060176..26060181 -
Mm9::chr5:5314581..5314592,-	p@chr5:5314581..5314592 -
Mm9::chr6:119217479..119217523,+	p@chr6:119217479..119217523 +
Mm9::chrX:139493649..139493658,+	p@chrX:139493649..139493658 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0032962	positive regulation of inositol trisphosphate biosynthetic process	0.00375270495224433
GO:0032959	inositol trisphosphate biosynthetic process	0.00375270495224433
GO:0032958	inositol phosphate biosynthetic process	0.00375270495224433
GO:0032960	regulation of inositol trisphosphate biosynthetic process	0.00375270495224433
GO:0006021	inositol biosynthetic process	0.00375270495224433
GO:0043647	inositol phosphate metabolic process	0.00375270495224433
GO:0032957	inositol trisphosphate metabolic process	0.00375270495224433
GO:0060133	somatotropin secreting cell development	0.00375270495224433
GO:0060126	somatotropin secreting cell differentiation	0.00450312257623173
GO:0043567	regulation of insulin-like growth factor receptor signaling pathway	0.00450312257623173
GO:0045913	positive regulation of carbohydrate metabolic process	0.0050033324553003
GO:0043255	regulation of carbohydrate biosynthetic process	0.0050033324553003
GO:0006109	regulation of carbohydrate metabolic process	0.00643250353835337
GO:0021984	adenohypophysis development	0.00643250353835337
GO:0008340	determination of adult life span	0.00700408972726694
GO:0048009	insulin-like growth factor receptor signaling pathway	0.00794538066611113
GO:0006020	inositol metabolic process	0.00794538066611113
GO:0010259	multicellular organismal aging	0.00833751668703983
GO:0021983	pituitary gland development	0.0142145434083468
GO:0021536	diencephalon development	0.0150009504920605
GO:0040018	positive regulation of multicellular organism growth	0.0150009504920605
GO:0001708	cell fate specification	0.0150009504920605
GO:0019319	hexose biosynthetic process	0.0150009504920605
GO:0046165	alcohol biosynthetic process	0.0150009504920605
GO:0046364	monosaccharide biosynthetic process	0.0150009504920605
GO:0045927	positive regulation of growth	0.0150009504920605
GO:0007568	aging	0.0155556883470946
GO:0030183	B cell differentiation	0.0187465618727708
GO:0035270	endocrine system development	0.0248141852991228
GO:0040014	regulation of multicellular organism growth	0.0259831151355832
GO:0035264	multicellular organism growth	0.0294896781300526
GO:0048732	gland development	0.0346440524221495
GO:0016051	carbohydrate biosynthetic process	0.0358591910391614
GO:0042113	B cell activation	0.0374417210532664
GO:0030098	lymphocyte differentiation	0.0393597288025601
GO:0003682	chromatin binding	0.0393961055216672
GO:0030900	forebrain development	0.0393961055216672
GO:0045165	cell fate commitment	0.0393961055216672
GO:0002521	leukocyte differentiation	0.0486140962192843
GO:0019318	hexose metabolic process	0.0486140962192843
GO:0005996	monosaccharide metabolic process	0.0488823455569572
GO:0031326	regulation of cellular biosynthetic process	0.0494922157546636

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
pituitary gland	3.71e-65	8
gland of diencephalon	3.71e-65	8
neuroendocrine gland	3.71e-65	8
diencephalon	2.77e-52	10
future diencephalon	2.77e-52	10
regional part of forebrain	7.80e-14	39
forebrain	7.80e-14	39
future forebrain	7.80e-14	39
anterior neural tube	1.69e-13	40
regional part of brain	8.56e-12	46
brain	1.50e-11	47
future brain	1.50e-11	47
pre-chordal neural plate	4.27e-11	49
neural tube	1.77e-10	52
neural rod	1.77e-10	52
future spinal cord	1.77e-10	52
neural keel	1.77e-10	52
regional part of nervous system	4.19e-10	54
endocrine gland	3.96e-09	60
neurectoderm	1.41e-08	64
neural plate	1.41e-08	64
presumptive neural plate	1.41e-08	64
gland	1.88e-08	65
endocrine system	1.17e-07	72
ecto-epithelium	1.48e-07	73
central nervous system	1.48e-07	73
nervous system	2.31e-07	75

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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