MCL coexpression mm9:927

Phase1 CAGE Peaks

	Short description
Mm9::chr12:100060445..100060448,-	p@chr12:100060445..100060448 -
Mm9::chr12:100115967..100115971,-	p@chr12:100115967..100115971 -
Mm9::chr12:100139474..100139485,-	p3@Eml5
Mm9::chr12:100139521..100139532,-	p4@Eml5
Mm9::chr12:100139625..100139682,-	p1@Eml5
Mm9::chr12:100139688..100139702,-	p2@Eml5
Mm9::chr1:158135128..158135162,-	p1@Fam163a
Mm9::chr4:117602331..117602344,-	p1@Artn

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030116	glial cell line-derived neurotrophic factor receptor binding	0.00756040102996768
GO:0050920	regulation of chemotaxis	0.00863880142734198
GO:0050926	regulation of positive chemotaxis	0.00863880142734198
GO:0050921	positive regulation of chemotaxis	0.00863880142734198
GO:0050927	positive regulation of positive chemotaxis	0.00863880142734198
GO:0050930	induction of positive chemotaxis	0.00863880142734198
GO:0050918	positive chemotaxis	0.00863880142734198
GO:0007422	peripheral nervous system development	0.0217230531538717

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
neuron	1.67e-09	33
neuronal stem cell	1.67e-09	33
neuroblast	1.67e-09	33
electrically signaling cell	1.67e-09	33
autonomic neuron	1.37e-07	9

Uber Anatomy

Ontology term	p-value	n
structure with developmental contribution from neural crest	7.06e-18	92
neurectoderm	9.97e-17	64
neural plate	9.97e-17	64
presumptive neural plate	9.97e-17	64
central nervous system	1.70e-16	73
ectoderm-derived structure	1.17e-15	95
ectoderm	1.17e-15	95
presumptive ectoderm	1.17e-15	95
nervous system	3.09e-15	75
ecto-epithelium	6.47e-14	73
pre-chordal neural plate	1.23e-12	49
regional part of nervous system	3.04e-11	54
neural tube	1.54e-10	52
neural rod	1.54e-10	52
future spinal cord	1.54e-10	52
neural keel	1.54e-10	52
brain	1.91e-09	47
future brain	1.91e-09	47
regional part of brain	6.68e-09	46
anterior neural tube	1.81e-08	40
regional part of forebrain	3.95e-08	39
forebrain	3.95e-08	39
future forebrain	3.95e-08	39
autonomic nervous system	1.37e-07	9
gray matter	2.60e-07	34

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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