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Coexpression cluster:C1325

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Full id: C1325_CD19_cord_Eosinophils_b_B_Neutrophils_acute



Phase1 CAGE Peaks

Hg19::chr11:102188224..102188235,+p3@BIRC3
Hg19::chr11:102188241..102188255,+p2@BIRC3
Hg19::chr17:38020392..38020477,-p1@IKZF3
Hg19::chr2:231090344..231090361,-p3@SP110
Hg19::chr2:231090433..231090469,+p1@SP140
Hg19::chr2:231090471..231090504,+p2@SP140


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0008270zinc ion binding0.0136564976516669
GO:0046914transition metal ion binding0.0136564976516669
GO:0005062hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity0.0136564976516669
GO:0005634nucleus0.021856297443892
GO:0043169cation binding0.021856297443892
GO:0046872metal ion binding0.021856297443892
GO:0043167ion binding0.021856297443892
GO:0003677DNA binding0.0396340780388288
GO:0043231intracellular membrane-bound organelle0.0396340780388288
GO:0043227membrane-bound organelle0.0396340780388288
GO:0007498mesoderm development0.0408971864373122



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte1.60e-59140
hematopoietic stem cell2.37e-49172
angioblastic mesenchymal cell2.37e-49172
nongranular leukocyte4.86e-49119
hematopoietic lineage restricted progenitor cell1.51e-48124
hematopoietic oligopotent progenitor cell3.22e-46165
hematopoietic multipotent progenitor cell3.22e-46165
hematopoietic cell3.25e-46182
lymphocyte1.82e-3053
common lymphoid progenitor1.82e-3053
lymphoid lineage restricted progenitor cell8.18e-3052
myeloid leukocyte9.03e-2376
granulocyte monocyte progenitor cell1.85e-1871
myeloid lineage restricted progenitor cell2.24e-1870
classical monocyte4.85e-1845
myeloid cell7.36e-18112
common myeloid progenitor7.36e-18112
CD14-positive, CD16-negative classical monocyte7.56e-1842
macrophage dendritic cell progenitor8.09e-1865
monopoietic cell3.65e-1763
monocyte3.65e-1763
monoblast3.65e-1763
promonocyte3.65e-1763
lymphocyte of B lineage9.87e-1624
pro-B cell9.87e-1624
T cell2.55e-1325
pro-T cell2.55e-1325
mature alpha-beta T cell9.46e-1218
alpha-beta T cell9.46e-1218
immature T cell9.46e-1218
mature T cell9.46e-1218
immature alpha-beta T cell9.46e-1218
B cell4.68e-1014
CD8-positive, alpha-beta T cell8.79e-0811
Uber Anatomy
Ontology termp-valuen
hematopoietic system7.41e-25102
blood island7.41e-25102
hemolymphoid system1.93e-22112
bone marrow2.09e-1480
bone element3.31e-1386
immune system2.62e-12115
adult organism5.24e-10115
blood1.18e-0915
haemolymphatic fluid1.18e-0915
organism substance1.18e-0915
skeletal element9.91e-09101
skeletal system9.91e-09101


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.